Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Dale R. Sengelaub"'
Autor:
Emily A. Hibbard, Dale R. Sengelaub
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Peripheral nerve injuries are the most common type of nerve trauma. We have been working with a novel repair technique using a plasmalemmal fusogen, polyethylene glycol (PEG), to re-fuse the membranes of severed axons. PEG-fusion repair allows for im
Externí odkaz:
https://doaj.org/article/671160db8e0d47e698b3618bbb838e18
Autor:
Liwen Zhou, Karthik Venkudusamy, Emily A. Hibbard, Yessenia Montoya, Alexa Olivarez, Cathy Z. Yang, Adelaide Leung, Varun Gokhale, Guhan Periyasamy, Zeal Pathak, Dale R. Sengelaub, George D. Bittner
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 9, Pp 2667-2681 (2025)
Successful polyethylene glycol fusion (PEG-fusion) of severed axons following peripheral nerve injuries for PEG-fused axons has been reported to: (1) rapidly restore electrophysiological continuity; (2) prevent distal Wallerian Degeneration and maint
Externí odkaz:
https://doaj.org/article/7d930b82484f4949acd85d59ca116d8c
Autor:
Emily A. Hibbard, Liwen Zhou, Cathy Z. Yang, Karthik Venkudusamy, Yessenia Montoya, Alexa Olivarez, George D. Bittner, Dale R. Sengelaub
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 7, Pp 2095-2107 (2025)
Peripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions; behavioral recovery is typically poor. We used a plasmalemmal fusogen, polyethylene glycol (PEG), to immediately fu
Externí odkaz:
https://doaj.org/article/3982a2a3b7fb414496c75811403fe165
Autor:
Cory Chew, Dale R Sengelaub
Publikováno v:
Neural Regeneration Research, Vol 15, Iss 8, Pp 1373-1376 (2020)
Injuries to spinal motoneurons manifest in a variety of forms, including damage to peripheral axons, neurodegenerative disease, or direct insult centrally. Such injuries produce a variety of negative structural and functional changes in both the dire
Externí odkaz:
https://doaj.org/article/802b43d0ac18437ab8b6b19d5d75ec71
Publikováno v:
Neural Regeneration Research, Vol 13, Iss 1, Pp 53-57 (2018)
Current Neuroscience dogma holds that transections or ablations of a segment of peripheral nerves produce: (1) Immediate loss of axonal continuity, sensory signaling, and motor control; (2) Wallerian rapid (1-3 days) degeneration of severed distal ax
Externí odkaz:
https://doaj.org/article/dc431b9521a54d94ae71b6ce59cbfa79
Autor:
Dale R Sengelaub, Xiao-Ming Xu
Publikováno v:
Neural Regeneration Research, Vol 13, Iss 6, Pp 971-976 (2018)
Spinal cord injury (SCI) results in lesions that destroy tissue and disrupt spinal tracts, producing deficits in locomotor and autonomic function. The majority of treatment strategies after SCI have concentrated on the damaged spinal cord, for exampl
Externí odkaz:
https://doaj.org/article/523fa526931a4b5ca02dcdf1072eb128
Autor:
Cameron L Ghergherehchi, Emily A Hibbard, Michelle Mikesh, George D Bittner, Dale R Sengelaub
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223443 (2019)
Polyethylene glycol repair (PEG-fusion) of severed sciatic axons restores their axoplasmic and membrane continuity, prevents Wallerian degeneration, maintains muscle fiber innervation, and greatly improves recovery of voluntary behaviors. We examined
Externí odkaz:
https://doaj.org/article/fabdce8b0eed4392afd502da2b799478
Autor:
Arthur P. Arnold, Xuqi Chen, Michael N. Grzybowski, Janelle M. Ryan, Dale R. Sengelaub, Tara Mohanroy, V. Andree Furlan, William Grisham, Lynn Malloy, Akiko Takizawa, Carrie B. Wiese, Laurent Vergnes, Helen Skaletsky, David C. Page, Karen Reue, Vincent R. Harley, Melinda R. Dwinell, Aron M. Geurts
Publikováno v:
bioRxiv
BackgroundWe have generated a rat model similar to the Four Core Genotypes mouse model, allowing comparison of XX and XY rats with the same type of gonad. The model detects novel sex chromosome effects (XX vs. XY) that contribute to sex differences i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559a36c2812afc8ea3d0f8c3e1815313
https://europepmc.org/articles/PMC9934672/
https://europepmc.org/articles/PMC9934672/
Publikováno v:
Journal of Neurotrauma. 38:1327-1337
Surviving motoneurons undergo dendritic atrophy after spinal cord injury (SCI), suggesting an important therapeutic target for neuroprotective strategies to improve recovery of function after SCI. Our previous studies showed that phospholipase A2 (PL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6b8d685d6cd49a9250f058431c0c04f
https://doi.org/10.1089/neu.2014.3690
https://doi.org/10.1089/neu.2014.3690
Publikováno v:
Developmental Neurobiology. 79:131-154
Partial depletion of spinal motoneuron populations induces dendritic atrophy in neighboring motoneurons, and treatment with testosterone protects motoneurons from induced dendritic atrophy. We explored a potential mechanism for this induced atrophy a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e1d85f28dd08286cf75c59b933f1902
https://doi.org/10.1002/dneu.22652
https://doi.org/10.1002/dneu.22652