Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Dale P Spangler"'
Autor:
Christopher R. Dalton, Nizal S. Chandrakumar, Mark L. Boys, G. Allen Nickols, Mark Russell, Maureen A. Nickols, Michael Clare, Dale P. Spangler, John A. Wendt, Christina N. Steininger, William F. Westlin, Yaping Wang, Tiffany Duffin, Michael B. Tollefson, Jon A. Klover, Sandra K. Freeman, Melanie L. Hanneke, Scott B. Mohler, Mary Beth Finn, Maria N. Nguyen, Heather G. Stenmark, Jeffery L. Keene, Hongwei Wu, Bipin N. Desai, Barbara B. Chen, V. Wayne Engleman, Yi X. Yu, Sarah A. Norring, Marisa M. Westlin, Lori A. Schretzman, Downs Victoria Leigh, Ish K. Khanna, Thomas D. Penning
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:839-844
We describe a series of 1,2,4-oxadiazoles, which are potent antagonists of the integrin alpha(v)beta3 and, in addition, show selectivity relative to the other beta3 integrin alpha(IIb)beta3. In whole cells, the majority of these analogs also demonstr
Autor:
Michele A Melton, Nigam P. Rath, Ming Zeng, Margaret L. Grapperhaus, Brian S Hickory, Jane L Wang, Elaine S. Krul, Deborah M. Heuvelman, Mark E. Smith, Kevin C. Glenn, Richard C Durley, Deborah A. Mischke, Bryan J. Witherbee, Daniel T. Connolly, Dale P Spangler, Dorothy D. Honda, Yvette M. Fobian, James A. Sikorski, Mark A. Massa, Barry L. Parnas
Publikováno v:
Journal of Medicinal Chemistry. 45:3891-3904
A novel series of substituted N-benzyl-N-phenyl-trifluoro-3-amino-2-propanols are described that reversibly inhibit cholesteryl ester transfer protein (CETP). Starting with screening lead 22, various structural features were explored with respect to
Autor:
William M. Moore, Barnett S. Pitzele, Timothy J. Hagen, Kam F. Fok, Dale P. Spangler, Margaret L. Grapperhaus, Pamela T. Manning, Jeffrey A. Scholten, Lijuan J. Wang, James A. Sikorski, Mihaly V. Toth, Gina M. Jerome
Publikováno v:
Heteroatom Chemistry. 13:77-83
The efficient syntheses of two new types of conformationally constrained S-[2-[(1-iminoethyl)amino]ethyl]homocysteine derivatives, 1-amino-3-[2[(1-iminoethyl)amino]ethylthio]cyclobutane carboxylic Acid (5) and (4S)-4-[[2-[(1-Iminoethyl)amino]ethyl]th
Autor:
John M. Cibulskis, and Patrick Dale McCray, Michael Cibulskis, Thompson N. Doman, Dale P. Spangler
Publikováno v:
Journal of Chemical Information and Computer Sciences. 36:1195-1204
Clustering of chemical inventories on the basis of structural similarity has been shown to be useful in a number of applications related to the utilization and enhancement of those inventories. However, the widely-used Jarvis−Patrick clustering alg
Autor:
Mark E. Smith, Daniel T. Connolly, Bryan J. Witherbee, Brian S. Hickory, James A. Sikorski, Mark A. Massa, Richard C. Durley, Dale P. Spangler
Publikováno v:
ChemInform. 32
Autor:
Chafiq Moummi, Dai-Chang Yang, Daniel L. Flynn, Roger Nosal, Daniel P. Becker, G. W. Gullikson, Dale P. Spangler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1613-1618
New aza(nor)adamantanes 1A , 1B , and 1C are described which exhibit properties of both 5-HT4 agonism and 5-HT3 antagonism. In particular, compound 1C [SC-52491], an azanoradamantane, exhibits an EC50 of 51 nM in a functional model of 5-HT4 agonism a
Autor:
E. Ann Hallinan, Gina M. Jerome, Barnett S. Pitzele, Dale P. Spangler, William M. Moore, Anna M. Stevens, Arija A. Bergmanis, Huey S. Shieh, Pamela T. Manning, Timothy J. Hagen
Publikováno v:
Journal of medicinal chemistry. 47(4)
5(S)-Fluoro-N6-(iminoethyl)-l-lysine (14), an analogue of the potent, selective induced nitric oxide synthase (iNOS) inhibitor iminoethyl-l-lysine (1), was synthesized and found to be a selective iNOS inhibitor.
Autor:
E. Ann Hallinan, Pamela T. Manning, Barnett S. Pitzele, Dale P. Spangler, William M. Moore, Gina M. Jerome, Steven W. Kramer, Stephen C. Houdek, Anna M. Stevens, Huey S. Shieh
Publikováno v:
Organicbiomolecular chemistry. 1(20)
In the literature, the introduction of fluorine into bioactive molecules has been known to enhance the biological activity relative to the parent molecule. Described in this article is the synthesis of 4R-fluoro-L-NIL (12) and 4,4-difluoro-L-NIL (23)
Autor:
Brian S. Hickory, Richard C. Durley, James A. Sikorski, Mark A. Massa, Mark E. Smith, Bryan J. Witherbee, Dale P. Spangler, Daniel T. Connolly
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(13)
A series of novel N,N-disubstituted trifluoro-3-amino-2-propanols has been prepared as potent inhibitors of cholesteryl ester transfer protein (CETP). Modifying the aromatic 3-tetrafluoroethoxy group in the lead molecule 1a with various heteroaryl mo
Publikováno v:
Journal of the American Chemical Society. 105:31-40
Alternative modes of catalysis of formaldehyde hydration by a single ancillary water molecule are investigated by ab initio calculations at the STO-3G level. A cyclic transition state (FW2 double dagger) involving formaldehyde with two molecules of w