Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Dale M, Walker"'
Autor:
Dale M. Walker, Tsvetelina I. Lazarova, Steven W. Riesinger, Miriam C. Poirier, Terri Messier, Brian Cunniff, Vernon E. Walker
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
The lack of anticancer agents that overcome innate/acquired drug resistance is the single biggest barrier to achieving a durable complete response to cancer therapy. To address this issue, a new drug family was developed for intracellular delivery of
Externí odkaz:
https://doaj.org/article/f4c45ff1604b44f9a8e00b84babc041b
Autor:
Michael J Bauer, George R. Douglas, Patricia B. Upton, Dale M. Walker, Vernon E. Walker, Timothy R. Fennell, James A. Swenberg
Publikováno v:
Chemical Research in Toxicology. 33:1609-1622
Acrylonitrile (ACN), which is a widely used industrial chemical, induces cancers in multiple organs/tissues of rats by unresolved mechanisms. For this report, evidence for ACN-induced direct/indirect DNA damage and mutagenesis was investigated by ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc467225c5df0ebce55722fd219b3a78
https://doi.org/10.1021/acs.chemrestox.0c00153
https://doi.org/10.1021/acs.chemrestox.0c00153
Publikováno v:
Chem Res Toxicol
Acrylonitrile (ACN), which is a widely used industrial chemical, induces cancers in the mouse via unresolved mechanisms. For this report, complementary and previously described methods were used to assess in vivo genotoxicity and/or mutagenicity of A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a5f3f025ea50051a8d3a4574fe0b27
https://europepmc.org/articles/PMC7477827/
https://europepmc.org/articles/PMC7477827/
Publikováno v:
Dose-Response, Vol 2 (2004)
A protective apoptosis-mediated (PAM) process that is turned on in mammalian cells by low-dose photon (X and γ) radiation and appears to also be turned on by the genotoxic chemical ethylene oxide is discussed. Because of the PAM process, exposure to
Externí odkaz:
https://doaj.org/article/ae015ef453544321b3c89a65f9dcd0fa
Publikováno v:
Dose-Response, Vol 1 (2003)
The linear nonthreshold (LNT) model plays a central role in low-dose radiation risk assessment for humans. With the LNT model, any radiation exposure is assumed to increase one's risk of cancer. Based on the LNT model, others have predicted tens of t
Externí odkaz:
https://doaj.org/article/4633f180fb3444cd95d3223639bfb913
Autor:
Richard J. Albertini, Dale M. Walker, Pamela M. Vacek, Mona Khattab, Lennart K. A. Lundblad, Vernon E. Walker, Janice A. Nicklas
Publikováno v:
Mutation research. Genetic toxicology and environmental mutagenesis. 820
The use of computed tomography (CT scans) has increased dramatically in recent decades, raising questions about the long-term safety of CT-emitted x-rays especially in infants who are more sensitive to radiation-induced effects. Cancer risk estimates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a517432e8cfcdef9aefb0c6ea6f0284d
https://pubmed.ncbi.nlm.nih.gov/28676266
https://pubmed.ncbi.nlm.nih.gov/28676266
Autor:
Natalia Y. Tretyakova, Amanda Degner, Vernon E. Walker, Janice A. Nicklas, Richard J. Albertini, Elizabeth W. Carter, Dale M. Walker
Publikováno v:
Chemico-Biological Interactions. 312:108797
Epidemiological studies of 1,3-butadiene (BD) exposures have reported a possible association with chronic myelogenous leukemia (CML), which is defined by the presence of the t(9;22) translocation (Philadelphia chromosome) creating an oncogenic BCR-AB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a1e77948c1de3c3d13a4967f4de9e9
https://doi.org/10.1016/j.cbi.2019.108797
https://doi.org/10.1016/j.cbi.2019.108797
Publikováno v:
Environmental and Molecular Mutagenesis. 54:268-280
The events or factors that lead from normal cell function to conditions and diseases such as aging or cancer reflect complex interactions between cells and their environment. Cellular stress responses, a group of processes involved in homeostasis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91858ef00ceda58f6499416b6e5737d0
https://doi.org/10.1002/em.21772
https://doi.org/10.1002/em.21772
Publikováno v:
Environmental and Molecular Mutagenesis. 54:281-293
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cf38b4c29483664ede0249639f843d4
https://doi.org/10.1002/em.21771
https://doi.org/10.1002/em.21771
Autor:
Thomas H. March, Vernon E. Walker, Miriam C. Poirier, Consuelo L. McCash, Meghan M. Carter, Steven K. Seilkop, Salina M. Torres, Dale M. Walker
Publikováno v:
Cardiovascular Toxicology. 10:37-50
The current study was designed to delineate temporal changes in cardiomyocytes and mitochondria at the light and electron microscopic levels in hearts of mice exposed transplacentally to commonly used nucleoside analogs (NRTIs). Pregnant CD-1 mice we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c849f7daa53f6b10a32d181a5a01c5a
https://doi.org/10.1007/s12012-010-9061-3
https://doi.org/10.1007/s12012-010-9061-3