Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Dale L. Morris"'
Autor:
Bruce L. Homer, Catharine J. Andresen, Daniel Morton, James A. Warneke, Dale L. Morris, Cedo M. Bagi, Michael A. Tones, Laurence O. Whiteley
Publikováno v:
Toxicologic Pathology. 43:411-423
Orally administered small molecule agonists of soluble guanylate cyclase (sGC) induced increased numbers of osteoclasts, multifocal bone resorption, increased porosity, and new bone formation in the appendicular and axial skeleton of Sprague-Dawley r
Autor:
Srinivasa R. Mantena, Cynthia M. Rohde, Dean Messing, Sharon A. Sokolowski, John W. Davis, Michael I. Jesson, Karrie A. Brenneman, Shawn P. O'Neil, Lindsay Tomlinson, Christopher G. Leonard, Laurence O. Whiteley, Steven Bailey, Deborah C. Carraher, Walter F. Bobrowski, Zachary S. Stewart, Yutian Zhan, W. Mark Vogel, Kimberly M. Shevlin, Dale L. Morris, Hungyun Lin, Shashi K. Ramaiah, Lauren M. Gauthier
Publikováno v:
Toxicologic Pathology. 42:229-242
Pancreatic toxicity commonly affects the endocrine or exocrine pancreas. However, it can also occur at the endocrine–exocrine interface (EEI), where the capillary network of the islet merges with the capillaries of the surrounding acinar tissue, th
Autor:
Debra S. Garner, Lori J. Kraus, Rajesh V. Devraj, Philip C. Rowlands, Jeffrey A. Kramer, Carl L. Alden, Kimberly M. Shevlin, John E. Sagartz, Fernando A. Happa, Wendy J. Komocsar, Robert J. Mourey, Shaun R. Selness, Jerry Z. Yang, Dale L. Morris, John Scott Daniels, Shawn P. O'Neil, Gerald R. Galluppi, Laurence O. Whiteley, Richard W. Gilles, Joseph P. Portanova, Joseph B. Monahan, David R. Anderson, John W. Davis, Cindy J. Gross, Kristen J. Nikula, Sandra W. Curtiss, John K. Walker, Dean Messing
Publikováno v:
Toxicologic Pathology. 38:606-618
Exposure to moderately selective p38α mitogen-activated protein kinase (MAPK) inhibitors in the Beagle dog results in an acute toxicity consisting of mild clinical signs (decreased activity, diarrhea, and fever), lymphoid necrosis and depletion in t
Publikováno v:
Journal of Toxicologic Pathology
The p38 mitogen-activated protein kinases (MAPKs) are members of discrete signal transduction pathways that have significant regulatory roles in a variety of biological processes, depending on the cell, tissue and organ type. p38 MAPKs are involved i
Autor:
Richard A Mueller, Jennie L. Walgren, Mollisa M. Elrick, David C. Thompson, Dale L. Morris, Michael D. Mitchell
Publikováno v:
Chemical Research in Toxicology. 21:859-868
We describe a novel peptide-based in vitro method for the detection of reactive metabolites that is amenable for use with microsomal or purified enzyme systems. Covalently bound adducts are detected by mass spectrometry using a surface-enhanced laser
Publikováno v:
Nature Reviews Drug Discovery. 6:636-649
Toxicity is a leading cause of attrition at all stages of the drug development process. The majority of safety-related attrition occurs preclinically, suggesting that approaches to identify 'predictable' preclinical safety liabilities earlier in the
Autor:
Jeffrey A. Kramer, Larry D. Kier, Carl L. Alden, Eric A.G. Blomme, Sandra W. Curtiss, Roderick T. Bunch, Kyle L. Kolaja, Mollisa M. Elrick, Marc A. Cabonce, Charles P. Rodi, Dale L. Morris
Publikováno v:
Toxicologic Pathology. 33:118-126
Hepatic enzyme inducers such as phenobarbital are often nongenotoxic rodent hepatocarcinogens. Currently, nongenotoxic hepatocarcinogens can only be definitively identified through costly and extensive long-term, repeat-dose studies (e.g., 2-year rod
Publikováno v:
Teratology. 58:197-204
Retinoic acid (RA) plays an important role in embryogenesis, by regulating morphogenesis, cell proliferation, differentiation, and extracellular matrix production. RA exposure on gestational day (GD) 12 in CD-1 mice results in delayed palatal shelf e
Autor:
Jacquline A. Brassard, Timothy J. Maziasz, Carl L. Alden, Benjamin E. Trump, Catherine M. Venturini, Roderick T. Bunch, Kanwar Nasir M. Khan, Alane T. Koki, Dale L. Morris
Publikováno v:
Toxicologic Pathology. 26:612-620
Cyclooxygenase (COX) exists in 2 related but unique isoforms: one is constitutive (COX-1) and functions in normal cell physiology, and the other is inducible (COX-2) and is expressed in response to inflammatory stimuli. Nonsteroidal antiinflammatory
Autor:
Sandra W. Curtiss, Julio C. Davila, Roderick T. Bunch, John E. Sagartz, Dale L. Morris, Carl L. Alden
Publikováno v:
Toxicologic Pathology. 26:492-500
The tumorigenic potential of phenobarbital was examined in a 26-wk carcinogenesis bioassay using p53 heterozygous mice and wild-type controls. Fifteen mice/sex/genotype were exposed to either 500 or 1,000 ppm phenobarbital in the diet. Dietary admini