Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Dale Kempf"'
Autor:
Anuradha Kumar, Somsundaram Chettiar, Brian S. Brown, Julie Early, Juliane Ollinger, Megan Files, Mai A. Bailey, Aaron Korkegian, Devon Dennison, Matthew McNeil, James Metz, Augustine Osuma, Michael Curtin, Aaron Kunzer, Gail Freiberg, Milan Bruncko, Dale Kempf, Tanya Parish
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-27 (2022)
Abstract We performed a high-throughput phenotypic whole cell screen of Mycobacterium tuberculosis against a diverse chemical library of approximately 100,000 compounds from the AbbVie corporate collection and identified 24 chemotypes with anti-tuber
Externí odkaz:
https://doaj.org/article/a7bda231d18f419a8fd60f4ebad065f6
Autor:
Amy E Marriott, Julio Furlong Silva, Nicolas Pionnier, Hanna Sjoberg, John Archer, Andrew Steven, Dale Kempf, Mark J Taylor, Joseph D Turner
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 6, p e0010474 (2022)
The development of new drugs targeting adult-stage lymphatic filarial nematodes is hindered by the lack of a robust long-term in vitro culture model. Testing potential direct-acting and anti-Wolbachia therapeutic candidates against adult lymphatic fi
Externí odkaz:
https://doaj.org/article/87510e0ffd114bda962aa13a4171b960
Autor:
Wenlin, Huang, Kayode K, Ojo, Zhongsheng, Zhang, Kasey, Rivas, Rama Subba Rao, Vidadala, Suzanne, Scheele, Amy E, DeRocher, Ryan, Choi, Matthew A, Hulverson, Lynn K, Barrett, Igor, Bruzual, Latha Kallur, Siddaramaiah, Keshia M, Kerchner, Matthew D, Kurnick, Gail M, Freiberg, Dale, Kempf, Wim G J, Hol, Ethan A, Merritt, Georg, Neckermann, Eugenio L, de Hostos, Nina, Isoherranen, Dustin J, Maly, Marilyn, Parsons, J Stone, Doggett, Wesley C, Van Voorhis, Erkang, Fan
Publikováno v:
ACS Medicinal Chemistry Letters
We previously discovered compounds based on a 5-aminopyrazole-4-carboxamide scaffold to be potent and selective inhibitors of CDPK1 from T. gondii. The current work, through structure–activity relationship studies, led to the discovery of compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::551bdf7e4f0d7c3e9fd7f8c2a88fa30a
https://pubmed.ncbi.nlm.nih.gov/26693272
https://pubmed.ncbi.nlm.nih.gov/26693272
Publikováno v:
Tetrahedron Letters. 27:2727-2730
The stereochemistries of the epimeric aldols of lasalocid have been determined by chemical correlation and new methods for establishing relative stereochemistry in this series have been discovered.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a60396c887a9743c5c4d1a546a977a42
https://doi.org/10.1016/s0040-4039(00)84628-6
https://doi.org/10.1016/s0040-4039(00)84628-6
Autor:
Dale Kempf
Publikováno v:
Tetrahedron Letters. 30:2029-2032
Metalation of N -methallyl amides occurs at nitrogen and at the remote methyl group. The dilithiated intermediates can be trapped with electrophiles to give substituted derivatives.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c632635135a82aafba4a0cf2682db46a
https://doi.org/10.1016/s0040-4039(01)93703-7
https://doi.org/10.1016/s0040-4039(01)93703-7
Autor:
Dale Kempf
Publikováno v:
ChemInform. 20
Metalation of N -methallyl amides occurs at nitrogen and at the remote methyl group. The dilithiated intermediates can be trapped with electrophiles to give substituted derivatives.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47dfa45a9960f27697a5b15c7e724009
https://doi.org/10.1002/chin.198948106
https://doi.org/10.1002/chin.198948106