Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Dale J, Kempf"'
Autor:
Peter C. Ray, Margaret Huggett, Penelope A. Turner, Malcolm Taylor, Laura A. T. Cleghorn, Julie Early, Anuradha Kumar, Shilah A. Bonnett, Lindsay Flint, Douglas Joerss, James Johnson, Aaron Korkegian, Steven Mullen, Abraham L. Moure, Susan H. Davis, Dinakaran Murugesan, Michael Mathieson, Nicola Caldwell, Curtis A. Engelhart, Dirk Schnappinger, Ola Epemolu, Fabio Zuccotto, Jennifer Riley, Paul Scullion, Laste Stojanovski, Lisa Massoudi, Gregory T. Robertson, Anne J. Lenaerts, Gail Freiberg, Dale J. Kempf, Thierry Masquelin, Philip A. Hipskind, Joshua Odingo, Kevin D. Read, Simon R. Green, Paul G. Wyatt, Tanya Parish
Publikováno v:
ACS Omega, Vol 6, Iss 3, Pp 2284-2311 (2021)
Externí odkaz:
https://doaj.org/article/0a27546e2eeb4807bfe33c85491f6518
Autor:
Marc P Hübner, Marianne Koschel, Dominique Struever, Venelin Nikolov, Stefan J Frohberger, Alexandra Ehrens, Martina Fendler, Iliana Johannes, Thomas W von Geldern, Kennan Marsh, Joseph D Turner, Mark J Taylor, Stephen A Ward, Kenneth Pfarr, Dale J Kempf, Achim Hoerauf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 8, p e0007636 (2019)
Depletion of Wolbachia endosymbionts of human pathogenic filariae using 4-6 weeks of doxycycline treatment can lead to permanent sterilization and adult filarial death. We investigated the anti-Wolbachia drug candidate ABBV-4083 in the Litomosoides s
Externí odkaz:
https://doaj.org/article/938a56b59b9342c292856f5bada424f0
Autor:
Thomas W von Geldern, Howard E Morton, Rick F Clark, Brian S Brown, Kelly L Johnston, Louise Ford, Sabine Specht, Robert A Carr, Deanne F Stolarik, Junli Ma, Matthew J Rieser, Dominique Struever, Stefan J Frohberger, Marianne Koschel, Alexandra Ehrens, Joseph D Turner, Marc P Hübner, Achim Hoerauf, Mark J Taylor, Stephen A Ward, Kennan Marsh, Dale J Kempf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 2, p e0007159 (2019)
There is a significant need for improved treatments for onchocerciasis and lymphatic filariasis, diseases caused by filarial worm infection. In particular, an agent able to selectively kill adult worms (macrofilaricide) would be expected to substanti
Externí odkaz:
https://doaj.org/article/68bed1add1a349b9b6bff6345f18be14
Autor:
Matthew A. Hulverson, Ryan Choi, Deborah A. Schaefer, Dana P. Betzer, Molly C. McCloskey, Grant R. Whitman, Wenlin Huang, Sangun Lee, Andy Pranata, Malcolm D. McLeod, Kennan C. Marsh, Dale J. Kempf, Bruce E. LeRoy, Mark T. Zafiratos, Aimee L. Bielinski, Robert C. Hackman, Kayode K. Ojo, Samuel L. M. Arnold, Lynn K. Barrett, Saul Tzipori, Michael W. Riggs, Erkang Fan, Wesley C. Van Voorhis
Publikováno v:
Antimicrobial Agents and Chemotherapy. 67
Recent advances on the development of bumped kinase inhibitors for treatment of cryptosporidiosis have focused on the 5-aminopyrazole-4-carboxamide scaffold, due to analogs that have less hERG inhibition, superior efficacy, and strong in vitro safety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61032458b2e188a2d38735d1346d5132
https://doi.org/10.1128/aac.01425-22
https://doi.org/10.1128/aac.01425-22
Autor:
Tanya Parish, Lindsay Flint, Anuradha Kumar, Lisa M. Massoudi, Paul Scullion, Gregory T. Robertson, Shilah A. Bonnett, Simon Green, Nicola Caldwell, Jennifer Riley, Gail M. Freiberg, Philip Arthur Hipskind, Michael Mathieson, Thierry Masquelin, Laste Stojanovski, Curtis A. Engelhart, Margaret Huggett, Dinakaran Murugesan, Abraham Lopez Moure, Fabio Zuccotto, Julie V. Early, Ola Epemolu, Paul G. Wyatt, Dale J. Kempf, Kevin D. Read, Susan Davis, Laura A. T. Cleghorn, James Johnson, Steven Mullen, Malcolm Taylor, Anne J. Lenaerts, Penelope A. Turner, Peter C. Ray, Joshua Odingo, Dirk Schnappinger, Aaron Korkegian, Douglas Joerss
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 3, Pp 2284-2311 (2021)
ACS Omega, Vol 6, Iss 3, Pp 2284-2311 (2021)
With the emergence of multi-drug-resistant strains of Mycobacterium tuberculosis, there is a pressing need for new oral drugs with novel mechanisms of action. A number of scaffolds with potent anti-tubercular in vitro activity have been identified fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::372e1778402b9efb43904bc638481606
http://europepmc.org/articles/PMC7841955
http://europepmc.org/articles/PMC7841955
Autor:
H. Michael Petrassi, Gregory T. Robertson, Carl Nathan, Clifton E. Barry, Kelly Chibale, Dale J. Kempf, Helena I. Boshoff, Joël Lelièvre, Ken Duncan, Bree B. Aldridge, Jeremy M. Rock, Betsy Russell, Peter Warner, Fabian Gusovsky, Michael R. Schrimpf, Véronique Dartois, James C. Sacchettini, Nader Fotouhi, Anne J. Lenaerts, Robert H. Bates, Anna Upton, David B. Olsen, Dirk Schnappinger, David G. Russell, Case W. McNamara, David Barros-Aguirre, Tanya Parish, Kyu Y. Rhee, Philip Arthur Hipskind, Valerie Mizrahi, Paul G. Wyatt, Steven Joseph Berthel, Alexander Pym, Xin-Jie Chu, Eric J. Rubin, Ying Yuan, Christopher B. Cooper
Publikováno v:
Nature medicine. 27(8)
The Tuberculosis Drug Accelerator, an experiment designed to facilitate collaboration in tuberculosis drug discovery by breaking down barriers among competing labs and institutions, has reached a 10-year landmark. We review the consortium’s achieve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca010dc18a791b197ac73fcbf7c0f4f
https://pubmed.ncbi.nlm.nih.gov/34226736
https://pubmed.ncbi.nlm.nih.gov/34226736
Autor:
Matthew A. Hulverson, Lynn K. Barrett, James J. Lynch, Dustin J. Maly, Grant R. Whitman, Rama Subba Rao Vidadala, Venkata Narayana Vidadala, Dale J. Kempf, Kennan C. Marsh, Ryan Choi, Wesley C. Van Voorhis, Kayode K. Ojo
Publikováno v:
ACS Infect Dis
Bumped kinase inhibitors (BKIs) that target Cryptosporidium parvum calcium-dependent protein kinase 1 have been well established as potential drug candidates against cryptosporidiosis. Recently, BKI-1649, with a 7H-pyrrolo[2,3-d]pyrimidin-4-amine, or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee639c01abab7b1d2d4d314241755cf
https://europepmc.org/articles/PMC8559537/
https://europepmc.org/articles/PMC8559537/
Autor:
Kennan C. Marsh, Dale J. Kempf
Publikováno v:
ACS Med Chem Lett
[Image: see text] Tropical diseases that disproportionally affect the world’s poorest people have traditionally been neglected from research efforts toward the discovery and development of new and effective therapies. Over the past two decades, maj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589dcb8cbfac572398bedc88eb989726
https://europepmc.org/articles/PMC7294558/
https://europepmc.org/articles/PMC7294558/
Autor:
Robert C. Hackman, Matthew A. Hulverson, Kayode K. Ojo, Molly C. McCloskey, Bruce E. Leroy, Michael W. Riggs, James J. Lynch, Wenlin Huang, Grant R. Whitman, Wesley C. Van Voorhis, Samuel L.M. Arnold, Lynn K. Barrett, Ryan Choi, Dale J. Kempf, Andrew Hemphill, Eugenio L. de Hostos, Rama Subba Rao Vidadala, Dustin J. Maly, Kennan C. Marsh, Luis Miguel Ortega-Mora, Dana P. Betzer, Robert K. M. Choy, Erkang Fan, J. Stone Doggett, Deborah A. Schaefer, Gail M. Freiberg
Publikováno v:
Int J Parasitol
Bumped Kinase Inhibitors (BKIs), targeting Calcium-dependent Protein Kinase 1 (CDPK1) in apicomplexan parasites with a glycine gatekeeper, are promising new therapeutics for apicomplexan diseases. Here we will review advances, as well as challenges a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899e6279ed341e193be6d60874abe419
Autor:
Frank Maldarelli, Sarah Palmer, Martin S King, Ann Wiegand, Michael A Polis, JoAnn Mican, Joseph A Kovacs, Richard T Davey, Diane Rock-Kress, Robin Dewar, Shuying Liu, Julia A Metcalf, Catherine Rehm, Scott C Brun, George J Hanna, Dale J Kempf, John M Coffin, John W Mellors
Publikováno v:
PLoS Pathogens, Vol 3, Iss 4, p e46 (2007)
Current antiretroviral therapy is effective in suppressing but not eliminating HIV-1 infection. Understanding the source of viral persistence is essential for developing strategies to eradicate HIV-1 infection. We therefore investigated the level of
Externí odkaz:
https://doaj.org/article/d12783e8e17c4822bde2560ae3f5522f