Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Dale J, Hamilton"'
Autor:
Manohar Kodavati, Haibo Wang, Wenting Guo, Joy Mitra, Pavana M. Hegde, Vincent Provasek, Vikas H. Maloji Rao, Indira Vedula, Aijun Zhang, Sankar Mitra, Alan E. Tomkinson, Dale J. Hamilton, Ludo Van Den Bosch, Muralidhar L. Hegde
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract This study establishes the physiological role of Fused in Sarcoma (FUS) in mitochondrial DNA (mtDNA) repair and highlights its implications to the pathogenesis of FUS-associated neurodegenerative diseases such as amyotrophic lateral sclerosi
Externí odkaz:
https://doaj.org/article/84695b5aec76489b85b86bbc091bf336
Autor:
Ashita Jain, Diego Casanova, Alejandra Valdivia Padilla, Angelica Paniagua Bojorges, Sivareddy Kotla, Kyung Ae Ko, Venkata S. K. Samanthapudi, Khanh Chau, Minh T. H. Nguyen, Jake Wen, Selina L. Hernandez Gonzalez, Shaefali P. Rodgers, Elizabeth A. Olmsted-Davis, Dale J. Hamilton, Cielito Reyes-Gibby, Sai-Ching J. Yeung, John P. Cooke, Joerg Herrmann, Eduardo N. Chini, Xiaolei Xu, Syed Wamique Yusuf, Momoko Yoshimoto, Philip L. Lorenzi, Brain Hobbs, Sunil Krishnan, Efstratios Koutroumpakis, Nicolas L. Palaskas, Guangyu Wang, Anita Deswal, Steven H. Lin, Jun-ichi Abe, Nhat-Tu Le
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality, especially among the aging population. The “response-to-injury” model proposed by Dr. Russell Ross in 1999 emphasizes inflammation as a critical factor in atherosclerosis
Externí odkaz:
https://doaj.org/article/f88dfe27f863446b91fe021a59c753ff
Autor:
Christine A. Beamish, PhD, A. Osama Gaber, MD, Daniel W. Fraga, MBA, Dale J. Hamilton, MD, Omaima M. Sabek, PhD
Publikováno v:
Transplantation Direct, Vol 8, Iss 10, p e1367 (2022)
Background. Islet and β-cell function is intrinsic to glucose homeostasis. Pancreatectomy and islet autotransplantation (PIAT) for chronic pancreatitis (CP) treatment is a useful model for assessing islet function in the absence of immune-suppressio
Externí odkaz:
https://doaj.org/article/67aaf6596c58465387c2fbbe2f89996c
Autor:
Preston R. Arnold, Mou Wen, Lei Zhang, Yuanlin Ying, Xiang Xiao, Xiufeng Chu, Guangchuan Wang, Xiaolong Zhang, Zhuyun Mao, Aijun Zhang, Dale J. Hamilton, Wenhao Chen, Xian C. Li
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
FOXP3 is the lineage-defining transcription factor for Tregs, a cell type critical to immune tolerance, but the mechanisms that control FOXP3 expression in Tregs remain incompletely defined, particularly as it relates to signals downstream of TCR and
Externí odkaz:
https://doaj.org/article/fc9e013cdb234eff8ca5aa5ede160916
Autor:
Sivareddy Kotla, Aijun Zhang, Masaki Imanishi, Kyung Ae Ko, Steven H. Lin, Young Jin Gi, Margie Moczygemba, Sevinj Isgandarova, Keri L. Schadler, Caroline Chung, Sarah A. Milgrom, Jose Banchs, Syed Wamique Yusuf, Diana N. Amaya, Huifang Guo, Tamlyn N. Thomas, Ying H. Shen, Anita Deswal, Joerg Herrmann, Eugenie S. Kleinerman, Mark L. Entman, John P. Cooke, Giovanni Schifitto, Sanjay B. Maggirwar, Elena McBeath, Anisha A. Gupte, Sunil Krishnan, Zarana S. Patel, Yisang Yoon, Jared K. Burks, Keigi Fujiwara, Paul S. Brookes, Nhat-Tu Le, Dale J. Hamilton, Jun-ichi Abe
Publikováno v:
Redox Biology, Vol 47, Iss , Pp 102132- (2021)
The incidence of cardiovascular disease (CVD) is higher in cancer survivors than in the general population. Several cancer treatments are recognized as risk factors for CVD, but specific therapies are unavailable. Many cancer treatments activate shar
Externí odkaz:
https://doaj.org/article/e0a94c31b512406eaddff3363f57a4c3
Autor:
Jun-dae Kim, Teng Zhou, Aijun Zhang, Shumin Li, Anisha A. Gupte, Dale J. Hamilton, Longhou Fang
Publikováno v:
Cells, Vol 11, Iss 22, p 3643 (2022)
Accumulating evidence indicates that the APOA1 binding protein (AIBP)—a secreted protein—plays a profound role in lipid metabolism. Interestingly, AIBP also functions as an NAD(P)H-hydrate epimerase to catalyze the interconversion of NAD(P)H hydr
Externí odkaz:
https://doaj.org/article/a8c8756c115e4f888f40082dbac6f3bb
Time-dependent replicative senescence vs. disturbed flow-induced pre-mature aging in atherosclerosis
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101614- (2020)
Accumulation of senescent cells has a causative role in the pathology of age-related disorders including atherosclerosis (AS) and cardiovascular diseases (CVDs). However, the concept of senescence is now drastically changing, and the new concept of s
Externí odkaz:
https://doaj.org/article/d89b6bcb5fdc43afa30d68b894701a1f
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 706 (2021)
Melanoma is one of the most malignant skin cancers that require comprehensive therapies, including chemotherapy. A plant-derived drug, plumbagin (PLB), exhibits an anticancer property in several cancers. We compared the cytotoxic and metabolic roles
Externí odkaz:
https://doaj.org/article/c1a9c2c18b8442379abd880262d10b01
Autor:
Suhong Wu, Aijun Zhang, Shumin Li, Somik Chatterjee, Ruogu Qi, Victor Segura‐Ibarra, Mauro Ferrari, Anisha Gupte, Elvin Blanco, Dale J. Hamilton
Publikováno v:
Advanced Science, Vol 5, Iss 3, Pp n/a-n/a (2018)
Abstract Aberrant mitochondrial energy transfer underlies prevalent chronic health conditions, including cancer, cardiovascular, and neurodegenerative diseases. Mitochondrial transplantation represents an innovative strategy aimed at restoring favora
Externí odkaz:
https://doaj.org/article/9ee13898597143bba0afb42b468b904b
Autor:
Dale J. Hamilton, Zhiyi Liu, Sheng Jiang, Dong Chen, Yatao Qiu, Kuojun Zhang, Yiwu Yao, Feng Li, Zheng Li
Publikováno v:
Journal of Medicinal Chemistry. 64:4020-4033
Abnormally high levels of class I histone deacetylases (HDACs) are associated with triple-negative breast cancer (TNBC) proliferation, malignant transformation, and poor prognosis of patients. Herein, we report a near-infrared imaging probe for TNBC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12028dba5825d279eacd2866c5eb3dd8
https://doi.org/10.1021/acs.jmedchem.0c02161
https://doi.org/10.1021/acs.jmedchem.0c02161