Zobrazeno 1 - 10
of 10 755
pro vyhledávání: '"Dale J"'
Autor:
Xinyu Wu, Margareta Go, Julie V. Nguyen, Nathan W. Kuchel, Bernadine G. C. Lu, Kathleen Zeglinski, Kym N. Lowes, Dale J. Calleja, Jeffrey P. Mitchell, Guillaume Lessene, David Komander, Matthew E. Call, Melissa J. Call
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Papain-like protease (PLpro) is an attractive drug target for SARS-CoV-2 because it is essential for viral replication, cleaving viral poly-proteins pp1a and pp1ab, and has de-ubiquitylation and de-ISGylation activities, affecting innate imm
Externí odkaz:
https://doaj.org/article/f2aa5295a8ff4f9095605b082b38d19a
Autor:
Manohar Kodavati, Haibo Wang, Wenting Guo, Joy Mitra, Pavana M. Hegde, Vincent Provasek, Vikas H. Maloji Rao, Indira Vedula, Aijun Zhang, Sankar Mitra, Alan E. Tomkinson, Dale J. Hamilton, Ludo Van Den Bosch, Muralidhar L. Hegde
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract This study establishes the physiological role of Fused in Sarcoma (FUS) in mitochondrial DNA (mtDNA) repair and highlights its implications to the pathogenesis of FUS-associated neurodegenerative diseases such as amyotrophic lateral sclerosi
Externí odkaz:
https://doaj.org/article/84695b5aec76489b85b86bbc091bf336
Autor:
Dale J. Stibbs, Pedro Silva Couto, Yasuhiro Takeuchi, Qasim A. Rafiq, Nigel B. Jackson, Andrea C.M.E. Rayat
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101264- (2024)
Quasi-perfusion culture was employed to intensify lentiviral vector (LV) manufacturing using a continuous stable producer cell line in an 8-day process. Initial studies aimed to identify a scalable seeding density, with 3, 4, and 5 × 104 cells cm−
Externí odkaz:
https://doaj.org/article/a2f19cde90514fd29c9d3b23d60c622c
Autor:
Dale J. Stibbs, Pedro Silva Couto, Yasuhiro Takeuchi, Qasim A. Rafiq, Nigel B. Jackson, Andrea C.M.E. Rayat
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101209- (2024)
Continuous manufacturing of lentiviral vectors (LVs) using stable producer cell lines could extend production periods, improve batch-to-batch reproducibility, and eliminate costly plasmid DNA and transfection reagents. A continuous process was establ
Externí odkaz:
https://doaj.org/article/9a07beca55a94568a5587afb1f9acd79
Publikováno v:
Actuators, Vol 13, Iss 9, p 326 (2024)
Surgical robotic tools are being developed for a variety of surgical procedures that are executed within small workspaces. Novel designs of miniaturized cable-actuated surgical tools for cleft palate repair have previously been developed. However, th
Externí odkaz:
https://doaj.org/article/080439ca46cf4bdeae704e0b98d9f9c8
Publikováno v:
Health Expectations, Vol 27, Iss 1, Pp n/a-n/a (2024)
Abstract Background This study aimed to determine how patients trade‐off the benefits and risks of two different types of procedures used to treat heart valve disease (HVD). It also aimed to determine patients' preferences for HVD treatments (predi
Externí odkaz:
https://doaj.org/article/4b59fc44bb3b4280aa92fdeb60533fff
Autor:
Monika M Derrien, Weston Brinkley, Dale J Blahna, Alberto J Rodríguez, Roseann Barnhill, Christopher Zuidema, Katie Beaver, Elisabeth Grinspoon, Sarah Jovan
Publikováno v:
Ecology and Society, Vol 29, Iss 1, p 28 (2024)
We propose the core collaborative community science framework, an original conceptual framework that integrates and modifies best practices from community science and collective impact groups to support investigations of environmental health and just
Externí odkaz:
https://doaj.org/article/29637ea4094a473facd5774dfefecd03
Autor:
Edmond M. Linossi, Kunlun Li, Gianluca Veggiani, Cyrus Tan, Farhad Dehkhoda, Colin Hockings, Dale J. Calleja, Narelle Keating, Rebecca Feltham, Andrew J. Brooks, Shawn S. Li, Sachdev S. Sidhu, Jeffrey J. Babon, Nadia J. Kershaw, Sandra E. Nicholson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/3771a83e093b48e7a5c69cac8e14f288
Autor:
Jerry Shen, BASc, MASc, David M. Fisher, FRCSC, FACS, Branavan Yasabala, BEng, Karen W.Y. Wong Riff, MD, PhD, FRCSC, Dale J. Podolsky, MD, PhD, FRCSC
Publikováno v:
Plastic and Reconstructive Surgery, Global Open, Vol 11, Iss 10, p e5363 (2023)
Summary:. Alveolar bone graft (ABG) surgery in cleft patients is technically challenging. The procedure requires design, dissection and release of soft tissue flaps to create a seal around the bone graft. In addition, visualization during the procedu
Externí odkaz:
https://doaj.org/article/bc07a48128d84c12bfc8b0ceb9a4cc5d
Autor:
Ashita Jain, Diego Casanova, Alejandra Valdivia Padilla, Angelica Paniagua Bojorges, Sivareddy Kotla, Kyung Ae Ko, Venkata S. K. Samanthapudi, Khanh Chau, Minh T. H. Nguyen, Jake Wen, Selina L. Hernandez Gonzalez, Shaefali P. Rodgers, Elizabeth A. Olmsted-Davis, Dale J. Hamilton, Cielito Reyes-Gibby, Sai-Ching J. Yeung, John P. Cooke, Joerg Herrmann, Eduardo N. Chini, Xiaolei Xu, Syed Wamique Yusuf, Momoko Yoshimoto, Philip L. Lorenzi, Brain Hobbs, Sunil Krishnan, Efstratios Koutroumpakis, Nicolas L. Palaskas, Guangyu Wang, Anita Deswal, Steven H. Lin, Jun-ichi Abe, Nhat-Tu Le
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality, especially among the aging population. The “response-to-injury” model proposed by Dr. Russell Ross in 1999 emphasizes inflammation as a critical factor in atherosclerosis
Externí odkaz:
https://doaj.org/article/f88dfe27f863446b91fe021a59c753ff