Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Dale G Deutsch"'
Autor:
Jinwoo Kim, Diane M Bogdan, Matthew W Elmes, Monaf Awwa, Su Yan, Joyce Che, Garam Lee, Dale G Deutsch, Robert C Rizzo, Martin Kaczocha, Iwao Ojima
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218619 (2019)
(-)-Incarvillateine (INCA) is a natural product that has garnered attention due to its purported analgesic effects and historical use as a pain reliever in China. α-Truxillic acid monoesters (TAMEs) constitute a class of inhibitors targeting fatty a
Externí odkaz:
https://doaj.org/article/22652621445e47aaae6cb8fa64861e67
Autor:
Martin Kaczocha, Mario J Rebecchi, Brian P Ralph, Yu-Han Gary Teng, William T Berger, William Galbavy, Matthew W Elmes, Sherrye T Glaser, Liqun Wang, Robert C Rizzo, Dale G Deutsch, Iwao Ojima
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94200 (2014)
The endocannabinoid anandamide (AEA) is an antinociceptive lipid that is inactivated through cellular uptake and subsequent catabolism by fatty acid amide hydrolase (FAAH). Fatty acid binding proteins (FABPs) are intracellular carriers that deliver A
Externí odkaz:
https://doaj.org/article/10794bacf1f74e80bc4ed21b0f3987e1
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79355 (2013)
The endocannabinoid system modulates numerous physiological processes including nociception and reproduction. Anandamide (AEA) is an endocannabinoid that is inactivated by cellular uptake followed by intracellular hydrolysis by fatty acid amide hydro
Externí odkaz:
https://doaj.org/article/5a10f9b88f30458d98a605a22e669269
Autor:
William T Berger, Brian P Ralph, Martin Kaczocha, Jing Sun, Trent E Balius, Robert C Rizzo, Samir Haj-Dahmane, Iwao Ojima, Dale G Deutsch
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50968 (2012)
Fatty acid binding proteins (FABPs), in particular FABP5 and FABP7, have recently been identified by us as intracellular transporters for the endocannabinoid anandamide (AEA). Furthermore, animal studies by others have shown that elevated levels of e
Externí odkaz:
https://doaj.org/article/a7d98d337e3642848b098d1e76f761d1
Autor:
Martin Kaczocha, Yuchen Zhou, Joyce Che, Hao-Chi Hsu, Iwao Ojima, Dale G. Deutsch, Olivia M. Joseph, Robert C. Rizzo, Matthew W. Elmes, Joseph M. Sweeney, Huilin Li
Publikováno v:
Biochemistry
Fatty acid binding protein 5 (FABP5) is a promising target for development of inhibitors to help control pain and inflammation. In this work, computer-based docking (DOCK6 program) was employed to screen ∼2 M commercially available compounds to FAB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c36c06a858d2fed2e7790b5520985e3
https://doi.org/10.1021/acs.biochem.9b00625
https://doi.org/10.1021/acs.biochem.9b00625
Autor:
Keith M. Studholme, Joyce Che, Joseph M. Sweeney, Christopher J. Giuliano, Olivia M. Joseph, Lauren E. Prentis, Matthew W. Elmes, Steven E. Glynn, Gregory Carbonetti, Dale G. Deutsch, Robert C. Rizzo, Luke L. McGoldrick, Martin Kaczocha
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
The increasing use of medical marijuana highlights the importance of developing a better understanding of cannabinoid metabolism. Phytocannabinoids, including ∆9-tetrahydrocannabinol (THC), are metabolized and inactivated by cytochrome P450 enzymes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6401ae2e444e6a2ffaa3e79776bddf
http://link.springer.com/article/10.1038/s41598-019-44108-3
http://link.springer.com/article/10.1038/s41598-019-44108-3
Autor:
Iwao Ojima, Matthew W. Elmes, Monaf Awwa, Joseph M. Sweeney, Martin Kaczocha, Jerome Falcone, Simon Tong, Yunrong Jing, Diane Bogdan, Brian P. Ralph, Dale G. Deutsch, Joyce Che, Longfei Wei, Gregory Carbonetti, Robert C. Rizzo, Liqun Wang, Norbert Smietalo, Huilin Li, Yuchen Zhou, Kongzhen Hu, Timothy Clement, Matthew Freitag, Olivia M. Joseph, Qianwen Gan, Hao-Chi Hsu, Su Yan, Gary Y.H. Teng
Publikováno v:
European Journal of Medicinal Chemistry. 154:233-252
Fatty acid binding proteins (FABPs) serve as critical modulators of endocannabinoid signaling by facilitating the intracellular transport of anandamide and whose inhibition potentiates anandamide signaling. Our previous work has identified a novel sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3edace6b7cb512c97128fd72506f1586
https://doi.org/10.1016/j.ejmech.2018.04.050
https://doi.org/10.1016/j.ejmech.2018.04.050
Autor:
Panayotis K. Thanos, Matthew W. Elmes, Roh-Yu Shen, Jeremy T. Miyauchi, Diane Bogdan, Dale G. Deutsch, Samir Haj-Dahmane, Stella E. Tsirka, Keith M. Studholme, Martha P. Kanjiya, Martin Kaczocha
Publikováno v:
Proceedings of the National Academy of Sciences. 115:3482-3487
Endocannabinoids (eCBs) are lipid-signaling molecules involved in the regulation of numerous behaviors and physiological functions. Released by postsynaptic neurons, eCBs mediate retrograde modulation of synaptic transmission and plasticity by activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf684a2d6e30472932311d1f16f0987
https://doi.org/10.1073/pnas.1721339115
https://doi.org/10.1073/pnas.1721339115
Autor:
Hao-Chi Hsu, Huilin Li, Matthew W. Elmes, Martin Kaczocha, Su Yan, Simon Tong, Yuchen Zhou, Iwao Ojima, Dale G. Deutsch, Robert C. Rizzo
Publikováno v:
Biochemistry. 56:3454-3462
Human FABP5 and FABP7 are intracellular endocannabinoid transporters. SBFI-26 is an α-truxillic acid 1-naphthyl monoester that inhibits the activities of FABP5 and FABP7 and produces antinociceptive and anti-inflammatory effects in mice. The synthes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6b4809ba130a8f3fc8c8904e6d3369
https://doi.org/10.1021/acs.biochem.7b00194
https://doi.org/10.1021/acs.biochem.7b00194
Publikováno v:
The FASEB Journal. 33
Epilepsy, a chronic disorder characterized by abnormal brain cell activity leading to recurrent seizures, has recently seen increased and FDA-approved usage of cannabidiol (CBD) as a treatment for ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::028e295eb2f26e7f0306f7760cb3f01c
https://doi.org/10.1096/fasebj.2019.33.1_supplement.804.6
https://doi.org/10.1096/fasebj.2019.33.1_supplement.804.6