Výsledky vyhledávání - "Dale F. Hirschkorn"

Effects of Blood Sample Age at Time of Separation on Measured Cytokine Concentrations in Human Plasma

Autor: Garth H. Utter, John W. Heitman, Rachael P. Jackman, Jacqueline P. Law, Nelly Gefter, Philip J. Norris, Michael P. Busch, Dale F. Hirschkorn

Publikováno v: Clinical and Vaccine Immunology. 18:318-326

Measurement of peripheral blood cytokines and other immunomodulatory proteins is a useful and popular tool for assessing human immune responses to a wide range of assaults. A common challenge in this work is obtaining fresh, high-quality samples and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9523aa109fe176965ca9d2bc40fcfe
https://doi.org/10.1128/cvi.00465-10

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HIV+ elite controllers have low HIV-specific T-cell activation yet maintain strong, polyfunctional T-cell responses

Autor: John W. Heitman, Philip J. Norris, Hope H. Biswas, Jeffrey N. Martin, Steven G. Deeks, Melissa R. Krone, Rachel E. Owen, Marion C. Lanteri, Dale F. Hirschkorn

Publikováno v: AIDS. 24:1095-1105

HIV elite controllers are a unique group of rare individuals who maintain undetectable viral loads in the absence of antiretroviral therapy. We studied immune responses in these individuals to inform vaccine development, with the goal of identifying

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd8fd500c152adfaac59f076fe53bf7
https://doi.org/10.1097/qad.0b013e3283377a1e

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Loss of T cell responses following long-term cryopreservation

Autor: Jeffery N Martin, Qi Xuan Tan, Rachel E. Owen, Frederick Hecht, Jeffery M. Harris, Mark A. Jacobson, John W. Heitman, Joseph M. McCune, Dale F. Hirschkorn, Brian Custer, Philip J. Norris, Elizabeth Sinclair, Steven G. Deeks, C. Lorrie Epling, Brinda Emu

Publikováno v: Journal of Immunological Methods. 326:93-115

Although cryopreservation of peripheral blood mononuclear cells (PBMC) is a commonly used technique, the degree to which it affects subsequent functional studies has not been well defined. Here we demonstrate that long-term cryopreservation has detri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d6f26d857f67e87785526618574a4d
https://doi.org/10.1016/j.jim.2007.07.012

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Antagonism of HIV-specific CD4+ T cells by C-terminal truncation of a minimum epitope

Autor: Philip J. Norris, Thomas O. Cameron, Dale F. Hirschkorn, Margaret J. Clark, John W. Heitman, Yuri Sykulev, Howell F. Moffett, Nadezhda Anikeeva, Bruce D. Walker, Jennifer D. Stone, Ingrid C. Wilson, Lawrence J. Stern

Publikováno v: Molecular Immunology. 43:1349-1357

Antagonism of T cell responses by variants of the cognate peptide is a potential mechanism of viral escape from immune responses and may play a role in the ability of HIV to evade immune control. We show here a rarely described mechanism of antagonis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e92fb1bddd278459fe490802f337360
https://doi.org/10.1016/j.molimm.2005.09.004

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Dynamics of viremia in early hepatitis C virus infection

Autor: Cristina Giachetti, James Gallarda, Charles M. Heldebrant, Richard Smith, Dale F. Hirschkorn, Michael P. Busch, Simone A. Glynn, Steven Kleinman, David Wright, Yongling Tu

Publikováno v: Transfusion. 45:994-1002

BACKGROUND: It is important to characterize viral dynamics in early hepatitis C virus (HCV) infection to further our understanding of viral pathogenesis and the potential for secondary transmission in acute infection through blood transfusion or othe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ad1d8b7956fd22b77b06ee3af0cf57
https://doi.org/10.1111/j.1537-2995.2005.04390.x

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Lymphocyte subset analysis on frozen whole blood

Autor: Delene K. Johnson, Dale F. Hirschkorn, H. Kyle Webster, James N. Lowder, Eberhard W. Fiebig, Michael P. Busch, Charlene C. Knape

Publikováno v: Cytometry. 29:340-350

An approach to perform lymphocyte subset analysis on frozen-thawed whole blood (F/T WB) is described. WB from 24 human immunodeficiency virus type 1 (HIV-1) seropositive individuals and 21 controls was analyzed fresh and after frozen storage (with or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e9e51086090da6d05adb3c9aa19a0013
https://doi.org/10.1002/(sici)1097-0320(19971201)29:4<340::aid-cyto11>3.0.co

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Evaluation of Four Alternative Methodologies for Determination of Absolute CD4+ Lymphocyte Counts

Autor: Delene K. Johnson, Michael P. Busch, Dale F. Hirschkorn

Publikováno v: Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology. 10:522-530

Standard methods for determining absolute CD3+CD4+ T-lymphocyte concentrations using combined results from flow cytometry and hematology analyzers are expensive and require fresh (< 18 h old) blood. We evaluated four new "alternative" methods for det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab4316a89b027f29081a90142d55d864
https://doi.org/10.1097/00042560-199510050-00005

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Infectivity in chimpanzees (Pan troglodytes) of plasma collected before HCV RNA detectability by FDA-licensed assays: implications for transfusion safety and HCV infection outcomes

Autor: Barbara Rehermann, Joo Chun Yoon, Harvey J. Alter, Eric Delwart, Steven Kleinman, Michael P. Busch, Vito Racanelli, Belinda L. Herring, Dale F. Hirschkorn, Krishna K. Murthy

Publikováno v: Blood. 119(26)

Serial plasma aliquots (50 mL) obtained from 10 commercial donors who converted from hepatitis C virus (HCV) RNA negative to positive were transfused into 2 chimpanzees to assess infectivity during early HCV infection. Plasma, obtained 4 days before

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fea060d3c3623dc4593f9cea69f7126
https://pubmed.ncbi.nlm.nih.gov/22745296

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Human T cell leukemia virus type 1 infection drives spontaneous proliferation of natural killer cells

Autor: Philip J. Norris, Deborah A. DeVita, Tzong-Hae Lee, Dale F. Hirschkorn, Edward L. Murphy

Publikováno v: Norris, PJ; Hirschkorn, DF; Devita, DA; Lee, TH; & Murphy, EL. (2010). Human T cell leukemia virus type 1 infection drives spontaneous proliferation of natural killer cells. Virulence, 1(1), 19-28. doi: 10.4161/viru.1.1.9868. UCSF: Retrieved from: http://www.escholarship.org/uc/item/3s26s2vp
Virulence, vol 1, iss 1

Most human T cell leukemia virus type 1 (HTLV-1) infected subjects remain asymptomatic throughout their lives, with a few individuals developing HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) or adult T cell leukemia. Lymphocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6869ac7c4aa4371bd4cf89cf7c732881
http://www.escholarship.org/uc/item/3s26s2vp

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The importance of Foxp3 antibody and fixation/permeabilization buffer combinations in identifying CD4+CD25+Foxp3+ regulatory T cells

Autor: Jacqueline P. Law, Hope H. Biswas, Rachel E. Owen, Philip J. Norris, Dale F. Hirschkorn, Marion C. Lanteri

Foxp3 is a key marker for CD4(+) regulatory T cells (T(regs)) and was used in developing a multiparameter flow cytometric panel to identify T(regs). Achieving reproducible staining and analysis first required optimization of Foxp3 staining. We presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99741752e24845f4e2b1c2ff0bc1ca52
https://europepmc.org/articles/PMC2862733/

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