Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Dale D O Martin"'
Autor:
Firyal Ramzan, Ashish Kumar, Fatima Abrar, Rachel A. V. Gray, Zurie E. Campbell, Lucia Meng Qi Liao, Anthony Dang, Oluwadurotimi Akanni, Colm Guyn, Dale D. O. Martin
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Multisystem proteinopathy (MSP) is a rare, dominantly inherited disorder that includes a cluster of diseases, including frontotemporal dementia, inclusion body myopathy, and Paget’s disease of bone. MSP is caused by mutations in the gene e
Externí odkaz:
https://doaj.org/article/54a17239fd5f492f81788d8f358ec73c
Autor:
Shaun S Sanders, Dale D O Martin, Stefanie L Butland, Mathieu Lavallée-Adam, Diego Calzolari, Chris Kay, John R Yates, Michael R Hayden
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 8, p e1004405 (2015)
Palmitoylation involves the reversible posttranslational addition of palmitate to cysteines and promotes membrane binding and subcellular localization. Recent advancements in the detection and identification of palmitoylated proteins have led to mult
Externí odkaz:
https://doaj.org/article/4e622abde3914052af71758d61c22c55
Autor:
Amit P Bhavsar, Nat F Brown, Jan Stoepel, Marcel Wiermer, Dale D O Martin, Karolynn J Hsu, Koshi Imami, Colin J Ross, Michael R Hayden, Leonard J Foster, Xin Li, Phil Hieter, B Brett Finlay
Publikováno v:
PLoS Pathogens, Vol 9, Iss 7, p e1003518 (2013)
To further its pathogenesis, S. Typhimurium delivers effector proteins into host cells, including the novel E3 ubiquitin ligase (NEL) effector SspH2. Using model systems in a cross-kingdom approach we gained further insight into the molecular functio
Externí odkaz:
https://doaj.org/article/18d8300ef9bc4b3f815eb0cf4287600f
Autor:
Firyal Ramzan, Fatima Abrar, Ashish Kumar, Lucia Meng Qi Liao, Zurie E. Campbell, Rachel V. Gray, Oluwadurotimi Akanni, Colm Guyn, Dale D. O. Martin
Multisystem proteinopathy (MSP) is a rare dominantly-inherited disorder that includes a cluster of diseases, including frontotemporal dementia, inclusion body myopathy, and Paget’s disease of bone. MSP is caused by mutations in the gene encoding Va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72f2ee1ef68a68b001b6fe7f0126e491
https://doi.org/10.1101/2023.03.31.531359
https://doi.org/10.1101/2023.03.31.531359
Publikováno v:
Frontiers in Physiology. 14
Introduction: Huntington disease is an autosomal dominant neurodegenerative disorder which is caused by a CAG repeat expansion in the HTT gene that codes for an elongated polyglutamine tract in the huntingtin (HTT) protein. Huntingtin is subjected to
Publikováno v:
Journal of Visualized Experiments.
Fatty acylation, the covalent addition of saturated fatty acids to protein substrates, is important in regulating a myriad of cellular functions in addition to its implications in cancer and neurodegenerative diseases. Recent developments in fatty ac
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
One of the first molecular events in neurodegenerative diseases, regardless of etiology, is protein mislocalization. Protein mislocalization in neurons is often linked to proteostasis deficiencies leading to the build-up of misfolded proteins and/or
Externí odkaz:
https://doaj.org/article/420de882f9c4473b80b4479ebe0f46d9
Autor:
Dagmar E. Ehrnhoefer, Dale D. O. Martin, Mandi E. Schmidt, Xiaofan Qiu, Safia Ladha, Nicholas S. Caron, Niels H. Skotte, Yen T. N. Nguyen, Kuljeet Vaid, Amber L. Southwell, Sabine Engemann, Sonia Franciosi, Michael R. Hayden
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-16 (2018)
Abstract Huntington disease (HD) is caused by the expression of mutant huntingtin (mHTT) bearing a polyglutamine expansion. In HD, mHTT accumulation is accompanied by a dysfunction in basal autophagy, which manifests as specific defects in cargo load
Externí odkaz:
https://doaj.org/article/3098d7176f61480fbe25947e9399afed