Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Dale C. Guenther"'
Autor:
Dale C. Guenther, Shohei Mori, Shigeo Matsuda, Jason A. Gilbert, Jennifer L. S. Willoughby, Sarah Hyde, Anna Bisbe, Yongfeng Jiang, Saket Agarwal, Mimouna Madaoui, Maja M. Janas, Klaus Charisse, Martin A. Maier, Martin Egli, Muthiah Manoharan
Publikováno v:
Journal of the American Chemical Society. 144:14517-14534
Autor:
Krishna Aluri, Swati Gupta, Sarah Leblanc, Martin Egli, Tim Racie, Muthiah Manoharan, Anna Bisbe, Peter Podbevšek, Vasant Jadhav, John Szeto, Christopher R. Brown, Hartmut Jahns, Ivan Zlatev, Dale C. Guenther, Martin Maier, Pawan Kumar, Adam Castoreno, Janez Plavec, Rohan Degaonkar
Publikováno v:
Nucleic Acids Research
In order to achieve efficient therapeutic post-transcriptional gene-silencing mediated by the RNA interference (RNAi) pathway, small interfering RNAs (siRNAs) must be chemically modified. Several supra-RNA structures, with the potential to stabilize
Autor:
Krishna Aluri, Scott Waldron, Karyn Schmidt, Maja M. Janas, Elena Castellanos-Rizaldos, Xiumin Liu, Michael Arciprete, Diane Ramsden, Jing Li, Vasant Jadhav, Robin McDougall, Christopher R. Brown, Bahru A. Habtemariam, Dale C. Guenther, Gabriel J. Robbie, Saket Agarwal, Muthiah Manoharan, Akshay Vaishnaw, Ivan Zlatev, Jeffrey Kurz, Jayaprakash K. Nair, Martin Maier, Saeho Chong, Sagar Agarwal, Christopher S. Theile, Steven Liou, Muthusamy Jayaraman, Varun Goel, Kevin Fitzgerald, Christopher MacLauchlin, Klaus Charisse, Joseph A Cichocki, Ju Liu, Yuanxin Xu, Peter F Smith, Jing-Tao Wu, Xuemei Zhang, Yongli Gu
Publikováno v:
Drug Metabolism and Disposition. 50:781-797
Conjugation of oligonucleotide therapeutics, including small interfering ribonucleic acids (siRNAs) or antisense oligonucleotides (ASOs) to N-acetylgalactosamine (GalNAc) ligands has become the primary strategy for hepatocyte-targeted delivery, and w
Autor:
Dale C, Guenther, Shohei, Mori, Shigeo, Matsuda, Jason A, Gilbert, Jennifer L S, Willoughby, Sarah, Hyde, Anna, Bisbe, Yongfeng, Jiang, Saket, Agarwal, Mimouna, Madaoui, Maja M, Janas, Klaus, Charisse, Martin A, Maier, Martin, Egli, Muthiah, Manoharan
Publikováno v:
Journal of the American Chemical Society. 144(32)
Although 2'-deoxy-2'-α-F-2'-β
Autor:
Pawan Kumar, Piet Herdewijn, Joel M. Harp, Ivan Zlatev, Muthiah Manoharan, Marie Capobianco, Martin Egli, Mark K Schlegel, Mikhail Abramov, Maja M. Janas, Charalambos Kaittanis, Yongfeng Jiang, Adam Castoreno, Rohan Degaonkar, Dale C. Guenther, Guy Schepers
Publikováno v:
Nucleic Acids Research
In this report, we investigated the hexopyranose chemical modification Altriol Nucleic Acid (ANA) within small interfering RNA (siRNA) duplexes that were otherwise fully modified with the 2'-deoxy-2'-fluoro and 2'-O-methyl pentofuranose chemical modi
Publikováno v:
Organic & Biomolecular Chemistry. 18:56-65
Four probe chemistries are characterized and compared with respect to thermal denaturation temperatures (Tms), thermodynamic parameters associated with duplex formation, and recognition of mixed-sequence double-stranded (ds) DNA targets: (i) oligodeo
Publikováno v:
Org Biomol Chem
Invader probes, i.e., DNA duplexes modified with +1 interstrand zippers of intercalator-functionalized nucleotides like 2’-O-(pyren-1-yl)methyl-RNA monomers, are energetically activated for sequence-unrestricted recognition of double-stranded DNA (
Publikováno v:
Org Biomol Chem
Development of molecules capable of binding to specific sequences of double-stranded (ds) DNA continues to attract considerable interest, as this may yield useful tools for applications in life science, biotechnology, and medicine. We have previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34159a822a4149ab0cc89dc42e336e84
https://europepmc.org/articles/PMC8625219/
https://europepmc.org/articles/PMC8625219/
Autor:
Kirk M. Brown, Jayaprakash K. Nair, Maja M. Janas, Yesseinia I. Anglero-Rodriguez, Lan T. H. Dang, Haiyan Peng, Christopher S. Theile, Elena Castellanos-Rizaldos, Christopher Brown, Donald Foster, Jeffrey Kurz, Jeffrey Allen, Rajanikanth Maganti, Jing Li, Shigeo Matsuda, Matthew Stricos, Tyler Chickering, Michelle Jung, Kelly Wassarman, Jeff Rollins, Lauren Woods, Alex Kelin, Dale C. Guenther, Melissa W. Mobley, John Petrulis, Robin McDougall, Timothy Racie, Jessica Bombardier, Diana Cha, Saket Agarwal, Lei Johnson, Yongfeng Jiang, Scott Lentini, Jason Gilbert, Tuyen Nguyen, Samantha Chigas, Sarah LeBlanc, Urjana Poreci, Anne Kasper, Arlin B. Rogers, Saeho Chong, Wendell Davis, Jessica E. Sutherland, Adam Castoreno, Stuart Milstein, Mark K. Schlegel, Ivan Zlatev, Klaus Charisse, Mark Keating, Muthiah Manoharan, Kevin Fitzgerald, Jing-Tao Wu, Martin A. Maier, Vasant Jadhav
Publikováno v:
Nature biotechnology. 40(10)
Therapeutics based on short interfering RNAs (siRNAs) delivered to hepatocytes have been approved, but new delivery solutions are needed to target additional organs. Here we show that conjugation of 2'-O-hexadecyl (C16) to siRNAs enables safe, potent
Autor:
Kallanthottathil G. Rajeev, Anna Bisbe, Gopal R Bommineni, Martin Egli, Lydia Perkins, Shigeo Matsuda, Martin Maier, Klaus Charisse, Dale C. Guenther, Muthiah Manoharan, Donald Foster, Joel M. Harp, Nate Taneja, Ivan Zlatev
Publikováno v:
Nucleic Acids Research. 46:8090-8104
Chemical modification is a prerequisite of oligonucleotide therapeutics for improved metabolic stability, uptake and activity, irrespective of their mode of action, i.e. antisense, RNAi or aptamer. Phosphate moiety and ribose C2'/O2' atoms are the mo