Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Dale E. Mais"'
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 2, Iss 5, Pp 429-438 (2012)
The pharmaceutical industry is presently suffering difficult times due to low productivity of new molecular entities. As a major source of drug leads, high-throughput screening (HTS) has been often criticized for its ‘dead end’ lead compounds. Ho
Externí odkaz:
https://doaj.org/article/b89436ae440e409a8d6809daa22f3771
Autor:
Christopher S. Rogers, Steven Denham, Thomas Vihtelic, John R. Swart, Chidozie Amuzie, Dale E. Mais
Publikováno v:
Toxicologic Pathology. 44:442-449
Models of atherosclerosis are used in preclinical studies but often fail to translate to humans. A model that better reflects human atherosclerosis is necessary. We recently engineered the ExeGen™ low-density lipoprotein receptor (LDLR) miniswine,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee9786c0e7710d20ff308c5e86f2c32
https://doi.org/10.1177/0192623315622304
https://doi.org/10.1177/0192623315622304
Autor:
Leonard Moise, H. Shaw Warren, Kanawat Chantaralawan, Dale E Mais, Lynchy Lezeau, William D. Martin, David Baker, Daniel Richer, Eric Berg, Mary Field, Anne S. De Groot, Jordan B. Fishman, Cybelle Luza, Russell Coleman, William R. Taylor, Jianping Yuan, Brandon Zeigler, Timothy Brauns, Pierre Leblanc, Jeffrey A. Gelfand, Christine M. Boyle, Mark C. Poznansky
Publikováno v:
Human Vaccines & Immunotherapeutics. 10:3022-3038
Development of effective vaccines against emerging infectious diseases (EID) can take as much or more than a decade to progress from pathogen isolation/identification to clinical approval. As a result, conventional approaches fail to produce field-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f14173dda43aab4fbda13126059dab4
https://doi.org/10.4161/hv.34413
https://doi.org/10.4161/hv.34413
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 2, Iss 5, Pp 429-438 (2012)
The pharmaceutical industry is presently suffering difficult times due to low productivity of new molecular entities. As a major source of drug leads, high-throughput screening (HTS) has been often criticized for its ‘dead end’ lead compounds. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b4ee36b63b56b3fffdbce38860fa46
http://www.sciencedirect.com/science/article/pii/S2211383512000548
http://www.sciencedirect.com/science/article/pii/S2211383512000548
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 13:837-848
Throughout the centuries, traditional Chinese medicine has been a rich resource in the development of new drugs. Modern drug discovery, which relies increasingly on automated high throughput screening and quick hit-to-lead development, however, is co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8f9655e36f3f07f2ed802a578a84a1
https://doi.org/10.2174/138620710793360257
https://doi.org/10.2174/138620710793360257
Autor:
Aimee Hogue, Eric G. Vajda, Francisco J. López, Dale E. Mais, Kelven Burnett, Keith B. Marschke, Lin Zhi, Arjan van Oeveren, Bijan Pedram, Yixing Shen, Yanling Chen, William Y. Chang, Kimberly N Griffiths, Martin D. Meglasson
Publikováno v:
Journal of Bone and Mineral Research. 24:231-240
Recent clinical trials with bisphosphonates and PTH have not supported the hypothesis that combination treatments with antiresorptive and anabolic agents would lead to synergistic activity. We hypothesized that combination treatment with a selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11520d3ccf194ce9a6e25dafa0fe1f01
https://doi.org/10.1359/jbmr.081007
https://doi.org/10.1359/jbmr.081007
Autor:
Jeffrey N. Miner, Deepa Rungta, Lino J. Valdez, Yongkai Li, Andrew Hudson, William W. Lamph, Jean Yen, Dean P. Phillips, and Andrés Negro-Vilar, Lin Zhi, Angie Vassar, Catalina Cuervo, Reid P. Bissonnette, Keith B. Marschke, E. Adam Kallel, Mark E. Adams, Catherine J. Gharbaoui, Robert I. Higuchi, Dale E. Mais, Steven L. Roach
Publikováno v:
Journal of Medicinal Chemistry. 50:4699-4709
Structure-activity relationship studies centered around 3'-substituted (Z)-5-(2'-(thienylmethylidene))1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-chromeno[3,4-f]quinolines are described. A series of highly potent and efficacious selective glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05412f680737616f8ba796c02fb26df7
https://doi.org/10.1021/jm070370z
https://doi.org/10.1021/jm070370z
Autor:
Sha Liu, Raymond F. Kauffman, Garret J. Etgen, Dale E. Mais, Allie Edward Tripp, Chahrzad Montrose-Rafizadeh, Yanping Xu, Leonard L. Winneroski, Brian A. Oldham, Patric James Hahn, Deepa Rungta, Dawn A. Brooks, William R. Bensch, Mary K. Peters, Sarah B. Wilson, Kathy M Ogilvie, Mccarthy James R, Jacob R Bosley, Samuel J. Dominianni, Christopher John Rito, Richard W. Zink, Robert J. Ardecky, James S. Bean, Anthony J. Shuker, Carol L. Broderick, Gregory A. Stephenson
Publikováno v:
Journal of Medicinal Chemistry. 47:2422-2425
The design and synthesis of the dual peroxisome proliferator activated receptor (PPAR) alpha/gamma agonist (S)-2-methyl-3-[4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)ethoxy]phenyl]-2-phenoxypropionic acid (2) for the treatment of type 2 diabetes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1308bb3472bf950182ed5ac246acab95
https://doi.org/10.1021/jm0342616
https://doi.org/10.1021/jm0342616
Autor:
Christopher M. Tegley, Mehrnouch Motamedi, Dale E. Mais, Keith B. Marschke, Josef D. Ringgenberg, Sarah J. West, Lin Zhi, William T. Schrader, Barbara Pio, Todd K. Jones, James P. Edwards
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:2075-2078
A series of 1,2-dihydrochromeno[3,4-f]quinoline derivatives was synthesized and tested in biological assays to evaluate the nonsteroidal progesterone receptor modulator pharmacophore (4) as antiprogestins. A number of potent analogues were identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28915ebc3cfc48f929f24dd1d13142fe
https://doi.org/10.1016/s0960-894x(03)00256-7
https://doi.org/10.1016/s0960-894x(03)00256-7
Autor:
Thomas Vihtelic, Christopher S. Rogers, Steven Denham, Chidozie Amuzie, Dale E. Mais, John R. Swart
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 34
Small animal models of atherosclerosis are commonly used in drug studies; however, the results often fail to translate into the clinic. A large animal model that more accurately reflects the human disease is needed. We recently developed a transgenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3aed2ae7133a76296f7858c5833af76c
https://doi.org/10.1161/atvb.34.suppl_1.657
https://doi.org/10.1161/atvb.34.suppl_1.657