Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Dalal El Khoury"'
Autor:
Keji Zhao, Bryan Venters, Utpal P. Davé, Dalal El-Khoury, Joyce Hardwick, Seeyoung Choi, Daniel B. Stamos, Claude Warzecha, Paul E. Love, Kairong Cui, Apratim Mitra, Bin Zhao, Karl Pfeifer, LiQi Li, Jan Y. Lee
Publikováno v:
Blood
Prolonged or enhanced expression of the proto-oncogene Lmo2 is associated with a severe form of T-cell acute lymphoblastic leukemia (T-ALL), designated early T-cell precursor ALL, which is characterized by the aberrant self-renewal and subsequent onc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1edb67b8b1f7477b1eec70d8d44c365f
https://europepmc.org/articles/PMC7316212/
https://europepmc.org/articles/PMC7316212/
Autor:
Renaud Lesourne, Ki-Duk Song, Lawrence E. Samelson, Dalal El-Khoury, Valarie A. Barr, Shoji Uehara, Ekaterina Zvezdova, Paul E. Love
Publikováno v:
The Journal of Immunology. 189:1154-1161
Themis1, a recently identified T cell protein, has a critical function in the generation of mature CD4+CD8− and CD4−CD8+ (CD4 and CD8 single-positive [SP]) thymocytes and T cells. Although Themis1 has been shown to bind to the adaptor proteins LA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc755048f73d44d9990b45bad9641eec
https://doi.org/10.4049/jimmunol.1200123
https://doi.org/10.4049/jimmunol.1200123
Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease
Autor:
Renaud Lesourne, SuJin Hwang, Jan Lee, Dalal El-Khoury, LiQi Li, Julia Pinkhasov, Paul E. Love, Ki-Duk Song
Publikováno v:
The Journal of Experimental Medicine
TCR signal attenuation selectively favors Foxp3 expression and T reg cell lineage commitment.
Negative selection and regulatory T (T reg) cell development are two thymus-dependent processes necessary for the enforcement of self-tolerance, and bo
Negative selection and regulatory T (T reg) cell development are two thymus-dependent processes necessary for the enforcement of self-tolerance, and bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90c435989496f93415175bc28135e18
http://europepmc.org/articles/PMC3457736
http://europepmc.org/articles/PMC3457736
Autor:
B. J. Fowlkes, Dalal El-Khoury, Matilde Canelles, Shoji Uehara, Paul E. Love, Sandra M. Hayes, LiQi Li
Publikováno v:
The Journal of Immunology. 176:75-84
During thymocyte development, CCR9 is expressed on late CD4−CD8− (double-negative (DN)) and CD4+CD8+ (double-positive) cells, but is subsequently down-regulated as cells transition to the mature CD4+ or CD8+ (single-positive (SP)) stage. This pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f404f4de315849d9fc114d279d61d313
https://doi.org/10.4049/jimmunol.176.1.75
https://doi.org/10.4049/jimmunol.176.1.75
Autor:
Connie L. Sommers, Kevin L. Steiner, Jan Lee, Jordan M. Gurson, Claudette L. Fuller, Elizabeth W. Shores, Paul E. Love, Dalal El-Khoury, Corinne L. DePersis, Lawrence E. Samelson
Publikováno v:
The Journal of Experimental Medicine
Linker for activation of T cells (LAT) is a scaffolding adaptor protein that is critical for T cell development and function. A mutation of LAT (Y136F) that disrupts phospholipase C-γ1 activation and subsequent calcium influx causes a partial block
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d132f4e757b5b67ebf5fb48be41956
https://doi.org/10.1084/jem.20041869
https://doi.org/10.1084/jem.20041869
Publikováno v:
The Journal of Experimental Medicine
The T cell antigen receptor complexes expressed on alphabeta and gammadelta T cells differ not only in their respective clonotypic heterodimers but also in the subunit composition of their CD3 complexes. The gammadelta T cell receptors (TCRs) express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552859debb1c868c0f6110591b7767bc
https://doi.org/10.1084/jem.20021196
https://doi.org/10.1084/jem.20021196
Autor:
Chiguang Feng, Kenneth J. Woodside, Elizabeth W. Shores, B. J. Fowlkes, Dalal El-Khoury, Ronald E. Gress, Matilde Cañelles, Jan Lee, Paul E. Love, Barbara A. Vance
Publikováno v:
Scopus-Elsevier
The early activation marker, CD69, is transiently expressed on activated mature T cells and on thymocytes that are undergoing positive or negative selection in the thymus. CD69 is a member of the NK gene complex family of C-type lectin-like signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59bd76474e64e3c47724152968aac27
https://doi.org/10.1093/intimm/dxf020
https://doi.org/10.1093/intimm/dxf020
Publikováno v:
The Journal of Immunology. 198:215.16-215.16
The T cell antigen receptor (TCR) is the primary signal transducing structure expressed on thymocytes and mature T cells, transmitting signals necessary for maturation and activation. The TCRα and β chains are rearranged from germline gene segments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1963868670670d9bdd60b804cdd67807
https://doi.org/10.4049/jimmunol.198.supp.215.16
https://doi.org/10.4049/jimmunol.198.supp.215.16
Autor:
Dalal El-Khoury, Jan Lee, Itoro Akpan, Lawrence E. Samelson, Valarie A. Barr, Ekaterina Zvezdova, Paul E. Love
Publikováno v:
Immunology and cell biology
Thymocyte development requires the coordinated input of signals that originate from numerous cell surface molecules. Although the majority of thymocyte signal-initiating receptors are lineage-specific, most trigger 'ubiquitous' downstream signaling p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae3728727bb264ec91443c2b2fd2820
https://pubmed.ncbi.nlm.nih.gov/24935457
https://pubmed.ncbi.nlm.nih.gov/24935457
Autor:
Jan Lee, Connie L. Sommers, Jan B. DeJarnette, Dalal El-Khoury, Kun Huang, Elizabeth W. Shores, Paul E. Love
Publikováno v:
The Journal of Experimental Medicine
The T cell antigen receptor (TCR) and pre-TCR complexes are composed of multiple signal-transducing subunits (CD3 gamma, CD3 delta, CD3 epsilon, and zeta) that each contain one or more copies of a semiconserved functional motif, the immunoreceptor ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc187de2e454efc2037c38ea3a6a800
https://doi.org/10.1084/jem.192.6.913
https://doi.org/10.1084/jem.192.6.913