Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Daksh Thaper"'
Autor:
Kevin J. Tam, Liangliang Liu, Michael Hsing, Kush Dalal, Daksh Thaper, Brian McConeghy, Parvin Yenki, Satyam Bhasin, James W. Peacock, Yuzhuo Wang, Artem Cherkasov, Paul S. Rennie, Martin E. Gleave, Christopher J. Ong
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract FOXA1 is a pioneer transcription factor that is frequently mutated in prostate, breast, bladder, and salivary gland malignancies. Indeed, metastatic castration-resistant prostate cancer (mCRPC) commonly harbour FOXA1 mutations with a prevale
Externí odkaz:
https://doaj.org/article/04472dd65cc24c0c8a00dc7c0f4fd55c
Autor:
Shaghayegh Nouruzi, Dwaipayan Ganguli, Nakisa Tabrizian, Maxim Kobelev, Olena Sivak, Takeshi Namekawa, Daksh Thaper, Sylvan C. Baca, Matthew L. Freedman, Adeleke Aguda, Alastair Davies, Amina Zoubeidi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Following androgen receptor pathway inhibition prostate cancers can differentiate towards the neuroendocrine lineage. Here, the authors identify epigenetic alterations regulated by ASCL1 and suggest targeting ASCL1 to reverse the neuroendocrine pheno
Externí odkaz:
https://doaj.org/article/d4c48d0f84e74da9bf7129acd29bbc7f
Autor:
James W Peacock, Ario Takeuchi, Norihiro Hayashi, Liangliang Liu, Kevin J Tam, Nader Al Nakouzi, Nastaran Khazamipour, Tabitha Tombe, Takashi Dejima, Kevin CK Lee, Masaki Shiota, Daksh Thaper, Wilson CW Lee, Daniel HF Hui, Hidetoshi Kuruma, Larissa Ivanova, Parvin Yenki, Ivy ZF Jiao, Shahram Khosravi, Alice L‐F Mui, Ladan Fazli, Amina Zoubeidi, Mads Daugaard, Martin E Gleave, Christopher J Ong
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 2, Pp 219-238 (2018)
Abstract Growth factor receptor tyrosine kinase (RTK) pathway activation is a key mechanism for mediating cancer growth, survival, and treatment resistance. Cognate ligands play crucial roles in autocrine or paracrine stimulation of these RTK pathway
Externí odkaz:
https://doaj.org/article/2f44866b8d6c48509b92457ef60f92f1
Publikováno v:
Proceedings, Vol 22, Iss 1, p 90 (2019)
No targeted therapies exist against aggressive neuroendocrine tumors; hence, these patients are limited to platinum-based chemotherapy that has not advanced in over three decades. [...]
Externí odkaz:
https://doaj.org/article/f479151c6891444a8e09ee47a83b7033
Autor:
Amina Zoubeidi, Himisha Beltran, Yuzhuo Wang, Colin C. Collins, Mark A. Rubin, Dong Lin, Martin E. Gleave, Ladan Fazli, Alexander W. Wyatt, Fraser Johnson, Arkhjamil Angeles, Ka Mun Nip, Randy Jama, Hidetoshi Kuruma, Kirsi Ketola, Alastair Davies, Sepideh Vahid, Daksh Thaper, Jennifer L. Bishop
Supplementary Figure S1. Generation of ENZR Xenografts and Cell Lines. Supplementary Figure S2. AR non-driven ENZR cells display a NE differentiation signature. Supplementary Figure S3. BRN2 expression is associated with PCa progression and a NE phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ee9134fae4edaedaa2c769135d438e
https://doi.org/10.1158/2159-8290.22530941
https://doi.org/10.1158/2159-8290.22530941
Autor:
Amina Zoubeidi, Martin E. Gleave, Daksh Thaper, Soojin Kim, Ladan Fazli, Eliana Beraldi, Barry R. Davies, Claire Crafter, Francois Lamoureux, Christian Thomas
PDF - 138 KB, Effect of AZD5363 on body weight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7998d5d6986e0f03b7816d98403f127b
https://doi.org/10.1158/1535-7163.22499205
https://doi.org/10.1158/1535-7163.22499205
Autor:
Amina Zoubeidi, Himisha Beltran, Yuzhuo Wang, Colin C. Collins, Mark A. Rubin, Dong Lin, Martin E. Gleave, Ladan Fazli, Alexander W. Wyatt, Fraser Johnson, Arkhjamil Angeles, Ka Mun Nip, Randy Jama, Hidetoshi Kuruma, Kirsi Ketola, Alastair Davies, Sepideh Vahid, Daksh Thaper, Jennifer L. Bishop
Supplementary methods, figure legends, and primer lists.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666fb64c0461ff005ce83454c4f57093
https://doi.org/10.1158/2159-8290.22530938
https://doi.org/10.1158/2159-8290.22530938
Autor:
Amina Zoubeidi, Martin E. Gleave, Daksh Thaper, Soojin Kim, Ladan Fazli, Eliana Beraldi, Barry R. Davies, Claire Crafter, Francois Lamoureux, Christian Thomas
PDF - 132KB, Effect of AZD5363 on nuclear translocation of AR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01523995fbe2419f442cd30cc147faf4
https://doi.org/10.1158/1535-7163.22499199.v1
https://doi.org/10.1158/1535-7163.22499199.v1
Autor:
Amina Zoubeidi, Himisha Beltran, Yuzhuo Wang, Colin C. Collins, Mark A. Rubin, Dong Lin, Martin E. Gleave, Ladan Fazli, Alexander W. Wyatt, Fraser Johnson, Arkhjamil Angeles, Ka Mun Nip, Randy Jama, Hidetoshi Kuruma, Kirsi Ketola, Alastair Davies, Sepideh Vahid, Daksh Thaper, Jennifer L. Bishop
RNAseq of ENZ-resistant cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25989953a5927ed31d090977f1ac919d
https://doi.org/10.1158/2159-8290.22530935
https://doi.org/10.1158/2159-8290.22530935
Autor:
Amina Zoubeidi, Martin E. Gleave, Daksh Thaper, Soojin Kim, Ladan Fazli, Eliana Beraldi, Barry R. Davies, Claire Crafter, Francois Lamoureux, Christian Thomas
PDF - 164KB, AZD5363 treatment activates the AR and receptor tyrosine kinases pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02aa1d66938cb38cbda97950ffe1c899
https://doi.org/10.1158/1535-7163.22499202
https://doi.org/10.1158/1535-7163.22499202