Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Dakota J. Suchyta"'
Autor:
Mona Jasmine R. Ahonen, Mark H Schoenfisc, Dakota J. Suchyta, Micah D. Brown, Kaitlyn R. Rouillard, Jackson R. Hall
Publikováno v:
ACS Biomater Sci Eng
Nitric oxide (NO) is a broad-spectrum antibacterial agent, making it an attractive alternative to traditional antibiotics for treating infections. To date, a direct comparison of the antibacterial activity of gaseous NO (gNO) versus water-soluble NO-
Publikováno v:
Biomacromolecules. 19:1189-1197
Low and high molecular weight alginate biopolymers were chemically modified to store and release potentially therapeutic levels of nitric oxide (NO). Carbodiimide chemistry was first used to modify carboxylic acid functional groups with a series of s
Publikováno v:
Bioconjugate Chemistry. 29:35-43
Hyperbranched polyamidoamines (h-PAMAM) were prepared using a one-pot reaction to have similar molecular weight to third generation PAMAM (G3-PAMAM) dendrimers, and then functionalized with N-diazeniumdiolate nitric oxide (NO) donors. A wide range of
Autor:
Mark H. Schoenfisch, Dakota J. Suchyta
Publikováno v:
ACS Biomaterials Science & Engineering. 3:2136-2143
We report the ability to readily tune NO release from N-diazeniumdiolate-encapsulated liposomal structures by altering the NO donor molecule structure and/or phospholipid composition (independently or in combination). While encapsulating more stable
Publikováno v:
Polymer Chemistry. 8:2552-2558
Chitosan was selectively monophosphorylated via reaction with phosphorus oxychloride (POCl3) to enhance water solubility while avoiding polyphosphate formation. The use of POCl3 resulted in negligible product degradation (i.e., breakdown of O-glycosi
Autor:
Mark H. Schoenfisch, Dakota J. Suchyta
Publikováno v:
RSC Advances. 7:53236-53246
In this study, fast and slow nitric oxide (NO)-releasing liposomes (half-lives of 2.5 and >72 h, respectively) were prepared by encapsulation of N-propyl-1,3-propanediamine/NO (PAPA/NO) and diethylenetriamine/NO (DETA/NO), respectively, via reverse p
Autor:
Dakota J. Suchyta, Mark H. Schoenfisch
Publikováno v:
Molecular Pharmaceutics. 12:3569-3574
The rapid decomposition of nitric oxide (NO) donors in aqueous environments remains a limitation for applications requiring extended NO release. Herein, we report the synthesis of dipalmitoylphosphatidylcholine-based liposomes capable of extended NO
Publikováno v:
Molecular Pharmaceutics
Heparin is a widely used anticoagulant due to its ability to inhibit key components in the coagulation cascade such as Factor Xa and thrombin (Factor IIa). Its potential to preferentially bind to antithrombin (ATIII) results in a conformational chang