Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Dakota J. Brock"'
Publikováno v:
Biomolecules, Vol 8, Iss 3, p 50 (2018)
Cell-penetrating peptides (CPPs) are typically prone to endocytic uptake into human cells. However, they are often inefficient at escaping from endosomes, which limits their ability to deliver cargos into cells. This review highlights the efforts tha
Externí odkaz:
https://doaj.org/article/7da251bbe3c7473b8c2b1623850d5d48
Autor:
Andrea L. J. Marschall, Helena M Kondow-McConaghy, Jean-Philippe Pellois, Rudolph L. Juliano, Dakota J. Brock, Elizabeth Hager, Alfredo Erazo-Oliveras, Kristin Graham, Kristina Najjar, Stefan Dübel, Jason Allen
Publikováno v:
ACS Chem Biol
Ineffective cellular delivery is a common problem in numerous biological applications. Developing delivery reagents that work robustly in a variety of experimental settings remains a challenge. Herein, we report how peptides derived from the prototyp
Autor:
Zlatko Brkljača, Mengqiu Jiang, Dakota J. Brock, Mario Vazdar, Jason Allen, Junjie Zhang, Hays S. Rye, Helena M Kondow-McConaghy, Jean-Philippe Pellois, Lauren Kustigian
Publikováno v:
Cell Chem Biol
Many cellular delivery reagents enter the cytosolic space of cells by escaping the lumen of endocytic organelles and, more specifically, late endosomes. The mechanisms involved in endosomal membrane permeation remain largely unresolved, which impedes
Autor:
Helena M Kondow-McConaghy, Jason Allen, Jean-Philippe Pellois, Zlatko Brkljača, Mengqiu Jiang, Junjie Zhang, Lauren Kustigian, Mario Vazdar, Hays S. Rye, Dakota J. Brock
Publikováno v:
SSRN Electronic Journal.
Many cellular delivery reagents enter the cytosolic space of cells by escaping the lumen of endocytic organelles and, more specifically, late endosomes. The mechanisms involved in endosomal membrane permeation remain largely unresolved, which impedes
Autor:
Kristina Najjar, Ting-Yi Wang, Dakota J. Brock, Alfredo Erazo-Oliveras, Jean-Philippe Pellois
Publikováno v:
Journal of Biological Chemistry. 292:847-861
Cell-penetrating peptides (CPPs) are well established as delivery agents for otherwise cell-impermeable cargos. CPPs can also theoretically be used to modulate intracellular processes. However, their susceptibility to proteolytic degradation often li
Publikováno v:
Chem
Our work on the complexation of fluoride anions using group 15 Lewis acids has led us to investigate the use of these main group compounds as anion transporters. In this paper, we report on the anion transport properties of tetraarylstibonium and tet
Publikováno v:
Bioconjugate chemistry. 30(2)
Cell delivery reagents often exploit the endocytic pathway as a route of cell entry. Once endocytosed, these reagents must overcome endosomal entrapment to ensure the release of their macromolecular cargo into the cytosol of cells. In this review, we
Autor:
Dat P. Truong, Jean-Philippe Pellois, Ting-Yi Wang, Alfredo Erazo-Oliveras, Dakota J. Brock, Austin R. Prater, Kristina Najjar
Publikováno v:
Cell Chemical Biology. 23:598-607
Endosomal entrapment is a severely limiting bottleneck in the delivery of biologics into cells. The compound dfTAT was recently found to circumvent this problem by mediating endosomal leakage efficiently and without toxicity. Herein, we report on the
Publikováno v:
Biomolecules, Vol 8, Iss 3, p 50 (2018)
Biomolecules
Biomolecules
Cell-penetrating peptides (CPPs) are typically prone to endocytic uptake into human cells. However, they are often inefficient at escaping from endosomes, which limits their ability to deliver cargos into cells. This review highlights the efforts tha
Autor:
Mengqiu Jiang, Dakota J. Brock, Hays S. Rye, Jean-Philippe Pellois, Kristin Graham, Alfredo Erazo-Oliveras, Lauren Kustigian, Ting-Yi Wang, Kristina Najjar, Junjie Zhang
Various densely charged polycationic species, whether of biological or synthetic origin, can penetrate human cells, albeit with variable efficiencies. The molecular underpinnings involved in such transport remain unclear. Herein, we assemble one, two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b5f1d14ce2b3615755596dd70d026b
https://europepmc.org/articles/PMC5948172/
https://europepmc.org/articles/PMC5948172/