Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging.

Autor: Jakobsen NA; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK; Oxford Centre for Haematology, NIHR Oxford Biomedical Research Centre, Oxford, UK., Turkalj S; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK; Oxford Centre for Haematology, NIHR Oxford Biomedical Research Centre, Oxford, UK., Zeng AGX; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Stoilova B; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Metzner M; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Rahmig S; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Nagree MS; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Shah S; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Moore R; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Usukhbayar B; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Angulo Salazar M; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Gafencu GA; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Kennedy A; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK; Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Newman S; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK; Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Kendrick BJL; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK; Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Taylor AH; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK; Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Afinowi-Luitz R; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK; Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Gundle R; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK; Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Watkins B; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK., Wheway K; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK., Beazley D; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK., Murison A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Aguilar-Navarro AG; Unidad de Investigación Médica en Enfermedades Oncológicas, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Flores-Figueroa E; Unidad de Investigación Médica en Enfermedades Oncológicas, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Dakin SG; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK., Carr AJ; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK; Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Nerlov C; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Dick JE; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Xie SZ; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Vyas P; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK; Oxford Centre for Haematology, NIHR Oxford Biomedical Research Centre, Oxford, UK; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK. Electronic address: paresh.vyas@imm.ox.ac.uk.

Publikováno v: Cell stem cell [Cell Stem Cell] 2024 Aug 01; Vol. 31 (8), pp. 1127-1144.e17. Date of Electronic Publication: 2024 Jun 24.

Exploring the burden, prevalence and associated factors of chronic musculoskeletal pain in migrants from North Africa and Middle East living in Europe: a scoping review.

Autor: Tsetseri MN; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, B4495, Headington, Oxford, OX3 7LD, UK. mnt4444@gmail.com., Keene DJ; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, B4495, Headington, Oxford, OX3 7LD, UK.; Faculty of Health and Life Sciences, University of Exeter, Exeter, UK., Silman AJ; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, B4495, Headington, Oxford, OX3 7LD, UK., Dakin SG; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, B4495, Headington, Oxford, OX3 7LD, UK.

Publikováno v: BMC public health [BMC Public Health] 2024 Mar 12; Vol. 24 (1), pp. 769. Date of Electronic Publication: 2024 Mar 12.

Editorial: Tendinopathy Research- How Cutting Edge Developments Inform the Future Therapeutic Landscape

Autor: Dakin, SG, Loiselle, AE, Traweger, A

Publikováno v: Frontiers in Bioengineering and Biotechnology. 10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07b14452071ecbb5c293338e4ded0a8
https://doi.org/10.3389/fbioe.2022.928144

Three-dimensional, in-vitro approaches for modelling soft-tissue joint diseases.

Autor: Johnson PA; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Ackerman JE; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Kurowska-Stolarska M; Research Into Inflammatory Arthritis Centre Versus Arthritis, University of Glasgow, Glasgow, UK., Coles M; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Buckley CD; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Dakin SG; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. Electronic address: stephanie.dakin@ndorms.ox.ac.uk.

Publikováno v: The Lancet. Rheumatology [Lancet Rheumatol] 2023 Sep; Vol. 5 (9), pp. e553-e563. Date of Electronic Publication: 2023 Aug 02.

Interleukin-17 Cytokines and Receptors: Potential Amplifiers of Tendon Inflammation

Autor: Mimpen, JY, Snelling, SJB, Carr, AJ, Dakin, SG

Publikováno v: Frontiers in Bioengineering and Biotechnology
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)

Interleukin (IL)-17A, a pro-inflammatory cytokine that is linked to the pathology of several inflammatory diseases, has been shown to be upregulated in early human tendinopathy and to mediate inflammatory and tissue remodelling events. However, it re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c67039d522c4a18e049221ee15fdb42
http://europepmc.org/articles/PMC8733930