Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Dajana Henschker"'
Autor:
Regina Ortmann, Ewald Beck, Jochen Wiesner, Armin Reichenberg, Martin Schlitzer, Dajana Henschker, Hassan Jomaa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:2163-2166
FR900098 represents an improved derivative of the new antimalarial drug fosmidomycin and acts through inhibition of the 1-deoxy-D-xylulose 5-phosphate (DOXP) reductoisomerase, an essential enzyme of the mevalonate independent pathway of isoprenoid bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f6b94518502337fc9c51d71e6728df
https://doi.org/10.1016/s0960-894x(03)00354-8
https://doi.org/10.1016/s0960-894x(03)00354-8
Publikováno v:
Antimicrobial Agents and Chemotherapy. 46:2889-2894
Fosmidomycin acts through inhibition of 1-deoxy- d -xylulose 5-phosphate (DOXP) reductoisomerase, a key enzyme of the nonmevalonate pathway of isoprenoid biosynthesis. It possesses potent antimalarial activity in vitro and in murine malaria. In a rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da3ad5d16bfed6d28f303d20f1285ad
https://doi.org/10.1128/aac.46.9.2889-2894.2002
https://doi.org/10.1128/aac.46.9.2889-2894.2002
Autor:
Timothy Haemers, Sara Van Poecke, Hassan Jomaa, Edwald Beck, Dajana Henschker, Jan Goeman, Jochen Wiesner, Serge Van Calenbergh
Publikováno v:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
In view of the promising antimalarial activity of fosmidomycin or its N-acetyl homologue FR900098, the objective of this work was to investigate the influence of aromatic substituents in the α-position of the phosphonate moiety. The envisaged analog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142632d94718cf32679179926e7db63d
https://doi.org/10.1002/chin.200628199
https://doi.org/10.1002/chin.200628199
Autor:
Jochen Wiesner, Hassan Jomaa, Ewald Beck, Dajana Henschker, Armin Reichenberg, Regina Ortmann, Martin Schlitzer
Publikováno v:
Archiv der Pharmazie. 338(7)
FR900098 represents a derivative of the new antimalarial drug fosmidomycin with enhanced activity. The mechanism of action is the inhibition of the 1-desoxy-D-xylulose 5-phosphate (DOXP) reductoisomerase, an essential enzyme of the mevalonate indepen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d480a543d88a95e5e9866b9a05d1db04
https://pubmed.ncbi.nlm.nih.gov/15996004
https://pubmed.ncbi.nlm.nih.gov/15996004
Autor:
Regina Ortmann, Jochen Wiesner, Armin Reichenberg, Dajana Henschker, Ewald Beck, Hassan Jomaa, Martin Schlitzer
Publikováno v:
Archiv der Pharmazie; Jul2005, Vol. 338 Issue 7, p305-314, 10p
Autor:
Hassan Jomaa, Armin Reichenberg, D. N. Ostrovsky, Martin Hintz, Jochen Wiesner, Evert C. Duin, Anke Henne, Dajana Henschker, Reiner Hedderich, Ewald Beck, Irina Steinbrecher, Boran Altincicek, Matthias Eberl, Ann-Kristin Kollas
Publikováno v:
FEBS Letters. (3):432-436
The gcpE gene product controls one of the terminal steps of isoprenoid biosynthesis via the mevalonate independent 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. This pathway is utilized by a variety of eubacteria, the plastids of algae and highe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4589cbf68be374fb6429c5ab799b78