Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Daizo Hamada"'
Autor:
Bochao Wang, Mitsuhiro Nishimura, Huamin Tang, Akiko Kawabata, Nora F Mahmoud, Zahra Khanlari, Daizo Hamada, Hiroki Tsuruta, Yasuko Mori
Publikováno v:
PLoS Pathogens, Vol 12, Iss 5, p e1005594 (2016)
The tegument protein U14 of human herpesvirus 6B (HHV-6B) constitutes the viral virion structure and is essential for viral growth. To define the characteristics and functions of U14, we determined the crystal structure of the N-terminal domain of HH
Externí odkaz:
https://doaj.org/article/92cc76a58f984846b03ead95154eea20
Autor:
Hidekazu Hiroaki, Kaori Satomura, Natsuko Goda, Yukako Nakakura, Minami Hiranuma, Takeshi Tenno, Daizo Hamada, Takahisa Ikegami
Publikováno v:
Molecules, Vol 23, Iss 10, p 2465 (2018)
Background: The tight junction is an intercellular adhesion complex composed of claudins (CLDs), occludin, and the scaffolding proteins zonula occludens 1 (ZO-1) and its two paralogs ZO-2 and ZO-3. ZO-1 is a multifunctional protein that contains thre
Externí odkaz:
https://doaj.org/article/1ad2d96f6eeb40a59e1439d0c0ad3117
Autor:
Mitsuhide Hamaguchi, Hironari Kamikubo, Kayo N Suzuki, Yoshihisa Hagihara, Itaru Yanagihara, Ikuhiro Sakata, Mikio Kataoka, Daizo Hamada
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71618 (2013)
Enterohaemorrhagic E. coli (EHEC) induces actin reorganization of host cells by injecting various effectors into host cytosol through type III secretion systems. EspB is the natively partially folded EHEC effector which binds to host α-catenin to pr
Externí odkaz:
https://doaj.org/article/4ce0a43ad1574e63841d00d6eeba227c
Autor:
Yoshiyuki Kasai, Katsumi Maenaka, Masahide Kikkawa, Daizo Hamada, Kimiko Kuroki, Sachie Manaka, Kazuhiro Mio, Haruki Matsubara, Chikara Sato, Ami Takahashi
Publikováno v:
The Journal of Immunology. 198:3399-3403
HLA-G is a natural tolerogenic molecule and has the following unique features: seven isoforms (HLA-G1 to HLA-G7), formation of disulfide-linked homodimers, and β2-microglobulin (β2m)-free forms. Interestingly, individuals null for the major isoform
Autor:
Naoko Adachi, Hideyuki Takahashi, Naoaki Saito, Takehiko Ueyama, Takahiro Seki, Norio Sakai, Aoi Nakazono, Daizo Hamada
Publikováno v:
The Journal of biological chemistry. 293(38)
Amyloid and amyloid-like protein aggregations are hallmarks of multiple, varied neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. We previously reported that spinocerebellar ataxia type 14 (SCA14), a dominant-inherited neur
Autor:
Mikio Kataoka, Satoru Unzai, Daizo Hamada, Marina Nawata, Shouhei Mine, Yuta Kobayashi, Hironari Kamikubo, Hirotaka Tsutsumi, Tsutomu Nakamura, Koichi Uegaki
Publikováno v:
The FEBS journal. 284(18)
Amyloid light-chain (AL) amyloidosis is a protein-misfolding disease characterized by accumulation of immunoglobulin light chains (LCs) into amyloid fibrils. Dimerization of a full length or variable domain (VL) of LC serves to stabilize the native s
Autor:
Masaki Yamamoto, Masaru Okabe, Hironari Kamikubo, Naokazu Inoue, Daizo Hamada, Masahito Ikawa, Mikio Kataoka, Yoshihisa Hagihara, Kunio Hirata
Publikováno v:
Development. 140(15):3221-3229
Although the membrane fusion of spermatozoon and egg cells is the central event of fertilization, the underlying molecular mechanism remains virtually unknown. Gene disruption studies have showed that IZUMO1 on spermatozoon and CD9 on oocyte are esse
Publikováno v:
Biochimica et biophysica acta. 1864(10)
Protein folding is a thermodynamic process driven by energy gaps between the native and unfolded states. Although a wealth of information is available on the structure of folded species, there is a paucity of data on unfolded species. Here, we analyz
Autor:
Takeshi Tenno, Masahiro Shirakawa, Natsuko Goda, Teikichi Ikura, Daizo Hamada, Yoshie Fujiwara, Kohei Akiyama, Hidekazu Hiroaki, Naoko Iwaya
Publikováno v:
FEBS Journal. 279:1339-1352
Katanin p60 (p60-katanin) is a microtubule (MT)-severing enzyme and its activity is regulated by the p80 subunit (adaptor-p80). p60-katanin consists of an N-terminal domain, followed by a single ATPase associated with various cellular activities (AAA
Autor:
Jun-ichi Nakayama, Kaori Shinmyozu, Yoshiro Tatsu, Koichi Uegaki, Daizo Hamada, Shinsuke Fujiwara, Kyoko Hiragami-Hamada
Publikováno v:
Molecular and Cellular Biology. 31:1186-1200
The phosphorylation of heterochromatin protein 1 (HP1) has been previously described in studies of mammals, but the biological implications of this modification remain largely elusive. Here, we show that the N-terminal phosphorylation of HP1α plays