Mechanisms of Cisplatin-Induced Apoptosis and of Cisplatin Sensitivity: Potential of BIN1 to Act as a Potent Predictor of Cisplatin Sensitivity in Gastric Cancer Treatment

Autor: Satoshi Tanida, Tsutomu Mizoshita, Keiji Ozeki, Hironobu Tsukamoto, Takeshi Kamiya, Hiromi Kataoka, Daitoku Sakamuro, Takashi Joh

Publikováno v: International Journal of Surgical Oncology, Vol 2012 (2012)

Cisplatin is the most important and efficacious chemotherapeutic agent for the treatment of advanced gastric cancer. Cisplatin forms inter- and intrastrand crosslinked DNA adducts and its cytotoxicity is mediated by propagation of DNA damage recognit

Externí odkaz: https://doaj.org/article/9a3521fdc6704a4dac97196bb4d42685

New Synthetic Lethality Re-Sensitizing Platinum-Refractory Cancer Cells to Cisplatin In Vitro: The Rationale to Co-Use PARP and ATM Inhibitors

Autor: Watson P. Folk, Alpana Kumari, Tetsushi Iwasaki, Erica K. Cassimere, Slovénie Pyndiah, Elizabeth Martin, Kelly Homlar, Daitoku Sakamuro

Publikováno v: International Journal of Molecular Sciences; Volume 22; Issue 24; Pages: 13324
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 13324, p 13324 (2021)

The pro-apoptotic tumor suppressor BIN1 inhibits the activities of the neoplastic transcription factor MYC, poly (ADP-ribose) polymerase-1 (PARP1), and ATM Ser/Thr kinase (ATM) by separate mechanisms. Although BIN1 deficits increase cancer-cell resis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f993e8b19e5984434f30e687837027

Endocrine disruptor exposure during development increases incidence of uterine fibroids by altering DNA repair in myometrial stem cells

Autor: Ayman Al-Hendy, Aymara Mas, Alpana Kumari, Qiwei Yang, Lauren E. Prusinski Fernung, Daitoku Sakamuro

Publikováno v: BIOLOGY OF REPRODUCTION
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe

Despite the major negative impact uterine fibroids (UFs) have on female reproductive health, little is known about early events that initiate development of these tumors. Somatic fibroid-causing mutations in mediator complex subunit 12 (MED12), the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a8923662eb14b36edaed04878981c7
https://pubmed.ncbi.nlm.nih.gov/29688260

Regulation of E2F1-induced apoptosis by poly(ADP-ribosyl)ation

Autor: E. K. Cassimere, Alpana Kumari, Daitoku Sakamuro, C. D. Palani, Slovénie Pyndiah, Tetsushi Iwasaki

Publikováno v: Cell Death & Differentiation. 22:311-322

The transcription factor adenovirus E2 promoter-binding factor (E2F)-1 normally enhances cell-cycle progression, but it also induces apoptosis under certain conditions, including DNA damage and serum deprivation. Although DNA damage facilitates the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c96c826f79595804f0c0289782eafc
https://doi.org/10.1038/cdd.2014.146

Abstract B34: PD-0332991/palbociclib facilitates the physical interaction between RB1 and BIN1 to increase the vulnerability of pediatric osteosarcoma cells to PARP inhibition

Autor: Watson P. Folk, Kelly Homlar, Daitoku Sakamuro

Publikováno v: Cancer Research. 78:B34-B34

Osteosarcoma (OS) is a sporadic bone malignancy that is diagnosed mainly in childhood and adolescence. Conventional genotoxic chemotherapy such as cisplatin and doxorubicin has been used as first-line therapy for pediatric OS patients. However, OS ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce0371d940d4e025b6a2104d96549e47
https://doi.org/10.1158/1538-7445.pedca17-b34