Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Daisy Sio Seng Lio"'
Autor:
Gahana Advani, Ya Chee Lim, Bruno Catimel, Daisy Sio Seng Lio, Nadia L. Y. Ng, Anderly C. Chüeh, Mai Tran, Mohd Ishtiaq Anasir, Heather Verkade, Hong-Jian Zhu, Benjamin E. Turk, Thomas E. Smithgall, Ching-Seng Ang, Michael Griffin, Heung-Chin Cheng
Publikováno v:
Cell Communication and Signaling, Vol 15, Iss 1, Pp 1-22 (2017)
Abstract Background C-terminal Src kinase (Csk) and Csk-homologous kinase (Chk) are the major endogenous inhibitors of Src-family kinases (SFKs). They employ two mechanisms to inhibit SFKs. First, they phosphorylate the C-terminal tail tyrosine which
Externí odkaz:
https://doaj.org/article/1eea7f5ad1d14905a145ead4e484aea3
Autor:
Courtney O. Zlatic, Renwick C. J. Dobson, Paul R. Gooley, Daisy Sio-Seng Lio, Heung-Chin Cheng, Tracy L Putoczki, Riley D. Metcalfe, Kaheina Aizel, Michael D. W. Griffin, Paul M Nguyen, Craig J. Morton, Michael W. Parker
Publikováno v:
J Biol Chem
Interleukin (IL) 11 activates multiple intracellular signaling pathways by forming a complex with its cell surface α-receptor, IL-11Rα, and the β-subunit receptor, gp130. Dysregulated IL-11 signaling has been implicated in several diseases, includ
Autor:
George Cao, Daisy Sio-Seng Lio, Michael D. W. Griffin, Ryan D. Mills, Lung-Yu Liang, Janetta G. Culvenor, Heung-Chin Cheng, Vijaya Kenche, Terrence D. Mulhern, Yee-Foong Mok
Publikováno v:
Journal of Neurochemistry. 147:409-428
The Parkinson's disease (PD)-causative leucine-rich repeat kinase 2 (LRRK2) belongs to the Roco family of G-proteins comprising a Ras-of-complex (Roc) domain followed by a C-terminal of Roc (COR) domain in tandem (called Roc-COR domain). Two prokaryo
Autor:
Heung-Chin Cheng, Daisy Sio Seng Lio, Hong-Jian Zhu, Bruno Catimel, Yeong-Chit Joel Chia, Benjamin Peng, Hong Wu, Ching-Seng Ang
Publikováno v:
Archives of Biochemistry and Biophysics. 587:48-60
Dephosphorylation of four major C-terminal tail sites and occupancy of the phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2]-binding site of PTEN cooperate to activate its phospholipid phosphatase activity and facilitate its recruitment to plasma mem
Autor:
Michael D. W. Griffin, Thomas E. Smithgall, Bruno Catimel, Ya Chee Lim, Hong-Jian Zhu, Anderly C. Chueh, Mohd Ishtiaq Anasir, Nadia L.Y. Ng, Mai Tran, Daisy Sio Seng Lio, Gahana Advani, Ching-Seng Ang, Heather Verkade, Benjamin E. Turk, Heung-Chin Cheng
Publikováno v:
Cell Communication and Signaling, Vol 15, Iss 1, Pp 1-22 (2017)
Cell Communication and Signaling : CCS
Cell Communication and Signaling : CCS
Background C-terminal Src kinase (Csk) and Csk-homologous kinase (Chk) are the major endogenous inhibitors of Src-family kinases (SFKs). They employ two mechanisms to inhibit SFKs. First, they phosphorylate the C-terminal tail tyrosine which stabiliz
Autor:
Bruno Catimel, Audrey Ferrand, Graham S. Baldwin, Heung-Chin Cheng, B. Philip Shehan, Raymond S. Norton, Daisy Sio Seng Lio
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1844:487-496
The Src-family tyrosine kinases (SFKs) are oncogenic enzymes that contribute to the initiation and progression of many types of cancer. In normal cells, SFKs are kept in an inactive state mainly by phosphorylation of a consensus regulatory tyrosine n
Autor:
Megan J. Bird, Daisy Sio-Seng Lio, Heung-Chin Cheng, Richard E.H. Wettenhall, Joanna E. Gajewski, Hong-Jian Zhu, Meredith O. Crowhurst, Junjun Liu
Publikováno v:
Protein Expression and Purification. 55:334-342
The dual specificity phosphatase PTEN exerts its tumour suppressor and cell-migration regulatory functions by dephosphorylating the phospholipid substrate, phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P(3)), and phosphotyrosine protein substrat
Autor:
Heung-Chin Cheng, Hong-Jian Zhu, Harshal Hanumant Nandurkar, Joel Yeong Chit Chia, Joanna E. Gajewski, Daisy Sio Seng Lio, Terrence D. Mulhern, Yi Xiao
Publikováno v:
Cellular Signalling. 19:1434-1445
PTEN exerts its tumour suppressor function by dephosphorylating the phospholipid second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP(3)). Herein, we demonstrate that the PTEN-catalysed PIP(3) dephosphorylation reaction involves two-steps:
Autor:
Janetta G. Culvenor, Andrew F. Hill, Daisy Sio Seng Lio, Su San Mok, Colin L. Masters, Chou Hung Sim, Heung-Chin Cheng
Publikováno v:
Human Molecular Genetics. 15:3251-3262
The Parkinson's disease (PD) causative PINK1 gene encodes a mitochondrial protein kinase called PTEN-induced kinase 1 (PINK1). The autosomal recessive pattern of inheritance of PINK1 mutations suggests that PINK1 is neuroprotective and therefore loss
Autor:
Boonyarin Jarasrassamee, Heung-Chin Cheng, Khai-Chew Chan, Mohammed Iqbal Hossain, Aainaa K. Roslee, Matthew A. Perugini, Daisy Sio-Seng Lio, Kim K. Ia, Renwick C. J. Dobson
Publikováno v:
Protein expression and purification. 74(2)
Csk-homologous kinase (CHK) is an important endogenous inhibitor constraining the oncogenic actions of Src-family kinases (SFKs) in cells. It suppresses SFK activity by specifically phosphorylating the conserved regulatory tyrosine near the C-terminu