Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Daisy N. Riquelme"'
Autor:
Douglas A. Lauffenburger, John S. Condeelis, Jenny Tadros, Frank B. Gertler, Michele Balsamo, Daisy N. Riquelme, Eliza Vasile, Guillaume Carmona, Duan Ma, Chandrani Mondal, Leslie Marie McClain
Publikováno v:
Scientific Reports
Nature
Nature
During tumor progression, alternative splicing gives rise to different Mena protein isoforms. We analyzed how Mena11a, an isoform enriched in epithelia and epithelial-like cells, affects Mena-dependent regulation of actin dynamics and cell behavior.
Autor:
John M. Lamar, Madeleine J. Oudin, Douglas A. Lauffenburger, Liliane C. Broye, Patricia J. Keely, Michael J. Cima, Sreeja B. Asokan, Oliver Jonas, Robert Langer, Charles A. Whittaker, Kari B. Wisinski, Duanduan Ma, Jeffrey Wyckoff, James E. Bear, Tatsiana Kosciuk, Bruna C. Guido, Frank B. Gertler, Richard O. Hynes, Daisy N. Riquelme
Publikováno v:
Cancer Discovery
Fibronectin (FN) is a major component of the tumor microenvironment, but its role in promoting metastasis is incompletely understood. Here we show that FN gradients elicit directional movement of breast cancer cells, in vitro and in vivo. Haptotaxis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295b18623105cc55ad96df21f4a4100c
Autor:
Douglas A. Lauffenburger, Shannon K. Hughes-Alford, Jenny Tadros, Richard O. Hynes, Shireen S. Rudina, Daisy N. Riquelme, Frank B. Gertler, Stephanie L. Gupton
Publikováno v:
The Journal of Cell Biology
Rockefeller UP
Rockefeller UP
Mena is an Ena/VASP family actin regulator with roles in cell migration, chemotaxis, cell–cell adhesion, tumor cell invasion, and metastasis. Although enriched in focal adhesions, Mena has no established function within these structures. We find th
Autor:
Michael J. May, Lashon M. Pringle, Daisy N. Riquelme, Andre M. Oliveira, Laura Quick, Robert A. Young, Margaret M. Chou
Publikováno v:
Oncogene
The NF-κB transcription factor plays a central role in diverse processes, including inflammation, proliferation and cell survival, and its activity is dysregulated in diseases such as auto-immunity and cancer. We recently identified the TRE17/ubiqui
Autor:
Ying Ye, Lashon M. Pringle, Laura Quick, Alan W. Lau, Daisy N. Riquelme, Andre M. Oliveira, Margaret M. Chou
Publikováno v:
Journal of Biological Chemistry. 285:37111-37120
Aneurysmal bone cyst (ABC) is a pediatric osseous tumor characterized by extensive destruction of the surrounding bone. The molecular mechanisms underlying its pathogenesis are completely unknown. Recent work showed that translocation of the TRE17/US
Publikováno v:
Portland Press
Bioscience Reports
Bioscience Reports
The members of the actin regulatory family of Ena/VASP proteins form stable tetramers. The vertebrate members of the Ena/VASP family, VASP, Mena and EVL, have many overlapping properties and expression patterns, but functional and regulatory differen
Publikováno v:
Cancer Research. 76:2875-2875
The program by which epithelial cells lose their polarity and close contacts with neighboring cells and acquire migratory and invasive properties is known as epithelial-mesenchymal transition (EMT). Initially identified as a critical developmental pr
Autor:
Tianying Jiang, Ying Ye, Andre M. Oliveira, Margaret M. Chou, Dina Lev, Lashon M. Pringle, Hongxin Wang, Daisy N. Riquelme, Arkadiusz Welman, Gerd A. Blobel, Alan W. Lau
Publikováno v:
Oncogene
Ye, Y, Pringle, L M, Lau, A W, Riquelme, D N, Wang, H, Jiang, T, Lev, D, Welman, A, Blobel, G A, Oliveira, A M & Chou, M M 2010, ' TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-kappa B ', Oncogene, vol. 29, no. 25, pp. 3619-3629 . https://doi.org/10.1038/onc.2010.116
Ye, Y, Pringle, L M, Lau, A W, Riquelme, D N, Wang, H, Jiang, T, Lev, D, Welman, A, Blobel, G A, Oliveira, A M & Chou, M M 2010, ' TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-kappa B ', Oncogene, vol. 29, no. 25, pp. 3619-3629 . https://doi.org/10.1038/onc.2010.116
Aneurysmal bone cyst (ABC) is an aggressive, pediatric bone tumor characterized by extensive destruction of the surrounding bone. Although first described over 60 years ago, its molecular etiology remains poorly understood. Recent work revealed that