Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial γδ T cell compartments

Autor: Anett Jandke, Daisy Melandri, Leticia Monin, Dmitry S. Ushakov, Adam G. Laing, Pierre Vantourout, Philip East, Takeshi Nitta, Tomoya Narita, Hiroshi Takayanagi, Regina Feederle, Adrian Hayday

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Butyrophilin-like genes are emerging as central to tissue associated γδ T cell compartments. Here, the authors show that the butyropilin-like gene-products exert their effects as combinatorially diverse heteromers that differentially affect the sel

Externí odkaz: https://doaj.org/article/c213401a85c342bf9b8247f63d992ad0

Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial γδ T cell compartments

Autor: Adrian Hayday, Hiroshi Takayanagi, Adam Laing, Leticia Monin, Dmitry S. Ushakov, Regina Feederle, Tomoya Narita, Pierre Vantourout, Daisy Melandri, Takeshi Nitta, Philip East, Anett Jandke

Publikováno v: Nat. Commun. 11:3769 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications

Butyrophilin-like (Btnl) genes are emerging as major epithelial determinants of tissue-associated γδ T cell compartments. Thus, the development of signature, murine TCRγδ+ intraepithelial lymphocytes (IEL) in gut and skin depends on Btnl family m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d83fd2193734f3699df3248c5b3db6
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=59829

The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells

Autor: Ana-Maria Lennon-Duménil, Enrique Gutiérrez-Martinez, Stéphanie Hugues, Grégoire Lauvau, Hannah Garner, Jakob Loschko, Emmanuel L. Gautier, Rachel Golub, Jake Y. Henry, Elisa Gomez-Perdiguero, Shinelle Menezes, Frederic Geissmann, M. Paula Longhi, Daisy Melandri, Christian E. Jacome-Galarza, Alain Bessis, Pierre Guermonprez, Thibaut Perchet, Giorgio Anselmi, Juan Dubrot, Sergio A. Quezada, Rajen Patel, Michel C. Nussenzweig

Publikováno v: Immunity
Immunity, Elsevier, 2016, 45 (6), pp.1205-1218. ⟨10.1016/j.immuni.2016.12.001⟩
Immunity, Vol. 45, No 6 (2016) pp. 1205-1218
Immunity, 2016, 45 (6), pp.1205-1218. ⟨10.1016/j.immuni.2016.12.001⟩
Menezes, S, Melandri, D, Anselmi, G, Perchet, T, Loschko, J, Dubrot, J, Patel, R, Gautier, E L, Hugues, S, Longhi, M P, Henry, J Y, Quezada, S A, Lauvau, G, Lennon-Duménil, A M, Gutiérrez-Martínez, E, Bessis, A, Gomez-Perdiguero, E, Jacome-Galarza, C E, Garner, H, Geissmann, F, Golub, R, Nussenzweig, M C & Guermonprez, P 2016, ' The Heterogeneity of Ly6C hi Monocytes Controls Their Differentiation into iNOS + Macrophages or Monocyte-Derived Dendritic Cells ', Immunity, vol. 45, no. 6, pp. 1205-1218 . https://doi.org/10.1016/j.immuni.2016.12.001

Summary Inflammation triggers the differentiation of Ly6Chi monocytes into microbicidal macrophages or monocyte-derived dendritic cells (moDCs). Yet, it is unclear whether environmental inflammatory cues control the polarization of monocytes toward e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f172401d5e17f7ff95af1d145a65b2
https://doi.org/10.1016/j.immuni.2016.12.001

The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness

Autor: Oxana Polyakova, Dieter Kabelitz, Oliver Nussbaumer, Adrian Hayday, Peter M. Irving, Pierre Vantourout, Iva Zlatareva, Susan D. John, Robin J. Dart, Salah Mansour, Daniela Wesch, Paul A. Bates, Natalie A. Roberts, Raphael A. G. Chaleil, Andrew Chancellor, Daisy Melandri

Publikováno v: Melandri, D, Zlatareva, I, Chaleil, R A G, Dart, R J, Chancellor, A, Nussbaumer, O, Polyakova, O, Roberts, N A, Wesch, D, Kabelitz, D, Irving, P M, John, S, Mansour, S, Bates, P A, Vantourout, P & Hayday, A C 2018, ' The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness ', Nature Immunology, vol. 19, no. 12, pp. 1352-1365 . https://doi.org/10.1038/s41590-018-0253-5

T lymphocytes expressing γδ T cell antigen receptors (TCRs) comprise evolutionarily conserved cells with paradoxical features. On the one hand, clonally expanded γδ T cells with unique specificities typify adaptive immunity. Conversely, large com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d68247b5f54364cebf6ec2ecb71de7
https://pubmed.ncbi.nlm.nih.gov/30420626