The ESX-5 System of Pathogenic Mycobacteria Is Involved In Capsule Integrity and Virulence through Its Substrate PPE10.

Autor: Louis S Ates, Aniek D van der Woude, Jovanka Bestebroer, Gunny van Stempvoort, René J P Musters, Juan J Garcia-Vallejo, Daisy I Picavet, Robert van de Weerd, Massimiliano Maletta, Coenraad P Kuijl, Nicole N van der Wel, Wilbert Bitter

Publikováno v: PLoS Pathogens, Vol 12, Iss 6, p e1005696 (2016)

Mycobacteria produce a capsule layer, which consists of glycan-like polysaccharides and a number of specific proteins. In this study, we show that, in slow-growing mycobacteria, the type VII secretion system ESX-5 plays a major role in the integrity

Externí odkaz: https://doaj.org/article/e7b5acba7b1d4311ab24e3979bb4f3f9

Cardiomyocyte-specific miRNA-30c over-expression causes dilated cardiomyopathy.

Autor: Wino J Wijnen, Ingeborg van der Made, Stephanie van den Oever, Monika Hiller, Bouke A de Boer, Daisy I Picavet, Iliana A Chatzispyrou, Riekelt H Houtkooper, Anke J Tijsen, Jaco Hagoort, Henk van Veen, Vincent Everts, Jan M Ruijter, Yigal M Pinto, Esther E Creemers

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e96290 (2014)

MicroRNAs (miRNAs) regulate many aspects of cellular function and their deregulation has been implicated in heart disease. MiRNA-30c is differentially expressed in the heart during the progression towards heart failure and in vitro studies hint to it

Externí odkaz: https://doaj.org/article/39d74b6e26954e6f905a52655dac842b

Effective melanoma immunotherapy in mice by the skin-depigmenting agent monobenzone and the adjuvants imiquimod and CpG.

Autor: Jasper G van den Boorn, Debby Konijnenberg, Esther P M Tjin, Daisy I Picavet, Nico J Meeuwenoord, Dmitri V Filippov, J P Wietze van der Veen, Jan D Bos, Cornelis J M Melief, Rosalie M Luiten

Publikováno v: PLoS ONE, Vol 5, Iss 5, p e10626 (2010)

Presently melanoma still lacks adequate treatment options for metastatic disease. While melanoma is exceptionally challenging to standard regimens, it is suited for treatment with immunotherapy based on its immunogenicity. Since treatment-related ski

Externí odkaz: https://doaj.org/article/46314c5ab5e149b893249a1b52bd1621

Evaluation of the Heat Shock Protein 90 Inhibitor Ganetespib as a Sensitizer to Hyperthermia-Based Cancer Treatments

Autor: Enzo M. Scutigliani, Yongxin Liang, Marloes IJff, Hans Rodermond, Xionge Mei, Miriam P. Korver, Vaneesha S. Orie, Ron A. Hoebe, Daisy I. Picavet, Arlene Oei, Roland Kanaar, Przemek M. Krawczyk

Publikováno v: Cancers, 14(21):5250. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers; Volume 14; Issue 21; Pages: 5250

Hyperthermia is being used as a radio- and chemotherapy sensitizer for a growing range of tumor subtypes in the clinic. Its potential is limited, however, by the ability of cancer cells to activate a protective mechanism known as the heat stress resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d50a4880dffeeb81fc955ae73e2fa6
https://pure.amc.nl/en/publications/evaluation-of-the-heat-shock-protein-90-inhibitor-ganetespib-as-a-sensitizer-to-hyperthermiabased-cancer-treatments(bbb07e88-3cd7-4c56-859d-f5edddd25274).html

The MEF2 transcriptional target DMPK induces loss of sarcomere structure and cardiomyopathy

Autor: Abdelaziz Beqqali, Meriem Bourajjaj, Maarten M.G. van den Hoogenhof, Ingeborg van der Made, Benoit Samson-Couterie, Elisabeth Ehler, Amin Damanafshan, Leon J. De Windt, Yigal M. Pinto, Henk A. van Veen, Ies Elzenaar, Ralph J. van Oort, Daisy I. Picavet

Publikováno v: Damanafshan, A, Elzenaar, I, Samson-Couterie, B, Van Der Made, I, Bourajjaj, M, Van Den Hoogenhof, M M, Van Veen, H A, Picavet, D I, Beqqali, A, Ehler, E, De Windt, L J, Pinto, Y M & Van Oort, R J 2018, ' The MEF2 transcriptional target DMPK induces loss of sarcomere structure and cardiomyopathy ', Cardiovascular Research, vol. 114, no. 11, pp. 1474-1486 . https://doi.org/10.1093/cvr/cvy091
Damanafshan, A, Elzenaar, I, Samson-Couterie, B, van der Made, I, Bourajjaj, M, van den Hoogenhof, M M G, van Veen, H A, Picavet, D I, Beqqali, A, Ehler, E, De Windt, L J, Pinto, Y M & van Oort, R J 2018, ' The MEF2 transcriptional target DMPK induces loss of sarcomere structure and cardiomyopathy ', Cardiovascular Research, vol. 114, no. 11 . https://doi.org/10.1093/cvr/cvy091
Cardiovascular Research, 114(11), 1474-1486. Oxford University Press
Cardiovascular research, 114(11), 1474-1486. Oxford University Press

AimsThe pathology of heart failure is characterized by poorly contracting and dilated ventricles. At the cellular level, this is associated with lengthening of individual cardiomyocytes and loss of sarcomeres. While it is known that the transcription

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7545f50fccdc2f578a41e11cf093bca
https://cris.maastrichtuniversity.nl/en/publications/78902b35-2464-4491-96ed-5989b92391a4