Genomic surveillance of extended-spectrum cephalosporin-resistant Escherichia coli isolated from poultry in the UK from 2016 to 2020

Autor: Nicholas Duggett, Manal AbuOun, Emma Stubberfield, Olivia Turner, Luke Randall, Robert Horton, Javier Nunez-Garcia, Daisy Gates, Jeremy Chanter, Chris Teale, Muna F. Anjum

Publikováno v: Frontiers in Microbiology, Vol 14 (2024)

IntroductionSurveillance is vital for monitoring the increasing risk of antimicrobial resistance (AMR) in bacteria leading to failures in humans and animals to treat infections. In a One Health context, AMR bacteria from livestock and food can transf

Externí odkaz: https://doaj.org/article/a4fe840802be4eabb8b516b8a5f81fb5

Structural basis of Blastomyces Endoglucanase-2 adjuvancy in anti-fungal and -viral immunity.

Autor: Lucas Dos Santos Dias, Hannah E Dobson, Brock Kingstad Bakke, Gregory C Kujoth, Junfeng Huang, Elaine M Kohn, Cleison Ledesma Taira, Huafeng Wang, Nitin T Supekar, J Scott Fites, Daisy Gates, Christina L Gomez, Charles A Specht, Stuart M Levitz, Parastoo Azadi, Lingjun Li, Marulasiddappa Suresh, Bruce S Klein, Marcel Wüthrich

Publikováno v: PLoS Pathogens, Vol 17, Iss 3, p e1009324 (2021)

The development of safe subunit vaccines requires adjuvants that augment immunogenicity of non-replicating protein-based antigens. Current vaccines against infectious diseases preferentially induce protective antibodies driven by adjuvants such as al

Externí odkaz: https://doaj.org/article/fc7f3feb47ae4cc8a5f6edd4c6048362

Levels of pathogen virulence and host resistance both shape the antibody response to an emerging bacterial disease

Autor: Geoffrey E. Hill, Kevin J. McGraw, Daisy Gates, Mathieu Giraudeau, Luc Tardy, Camille Bonneaud, Molly Staley

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2021, 11 (1), ⟨10.1038/s41598-021-87464-9⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports, 2021, 11 (1), ⟨10.1038/s41598-021-87464-9⟩

Quantifying variation in the ability to fight infection among free-living hosts is challenging and often constrained to one or a few measures of immune activity. While such measures are typically taken to reflect host resistance, they can also be sha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08306289ba6b90af441a7f126b7b5ed
https://hal.archives-ouvertes.fr/hal-03418447/document

Polymeric Pathogen-Like Particles-Based Combination Adjuvants Elicit Potent Mucosal T Cell Immunity to Influenza A Virus

Autor: Randall Toy, Krishnendu Roy, Chandranaik B. Marinaik, M. Suresh, Bhawana Pandey, Brock Kingstad-Bakke, Gabriela Vogel, Autumn Larsen, Woojong Lee, Daisy Gates, Yoshihoro Kawaoka, Pallab Pradhan, Tracy Luu

Publikováno v: Frontiers in Immunology, Vol 11 (2021)
Frontiers in Immunology

Eliciting durable and protective T cell-mediated immunity in the respiratory mucosa remains a significant challenge. Polylactic-co-glycolic acid (PLGA)-based cationic pathogen-like particles (PLPs) loaded with TLR agonists mimic biophysical propertie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b759ada57e7f5b413cccbbdc9d0ccf
https://www.frontiersin.org/articles/10.3389/fimmu.2020.559382/full