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Synthesis of N-arylated oxazolidinones via a palladium catalyzed cross coupling reaction. Application to the synthesis of the antibacterial agent Dup-721

Autor: Daisy Pireh, Stevan W. Djuric, Richard J. Sciotti, David Madar, Paul E. Wiedeman, Marina A. Pliushchev, Jonathan Pease, Hana Kopecka

Publikováno v: Tetrahedron Letters. 42:3681-3684

A method for the intermolecular coupling of aryl bromides and oxazolidinones is described. Application to intermediates useful for the preparation of a known class of antibacterial agent and the synthesis of the known antibacterial oxazolidinone Dup-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8badd88a9d50772a71d9374962aca2c
https://doi.org/10.1016/s0040-4039(01)00559-7

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Novel 3-deoxy-3-descladinosyl-6-O-methyl erythromycin a analogues. Synthesis and in vitro activity

Autor: Pauline M. Johnson, Angela M. Nilius, Daniel T. W. Chu, Daisy Pireh, Yat Sun Or, Robert K. Flamm, Richard L. Elliott, Jacob J. Plattner

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 7:641-646

A series of novel 3-deoxy-3-des-cladinosyl-6- O -methyl erythromycin A analogues has been synthesized and evaluated in vitro for antibacterial activity. These analogues were readily synthesized by tributyltin hydride-mediated radical reduction of a 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::094ccd16b9b0ab9315e1d2a3662a7cf7
https://doi.org/10.1016/s0960-894x(97)00078-4

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Synthesis and evaluation of water soluble indole pyrrolothiazole paf antagonists

Autor: Terrance J. Magoc, Richard G. Conway, Douglas H. Steinman, Daisy Pireh, Michael L. Curtin, James H. Holms, James B. Summers, H. Robin Heyman, Steven K. Davidsen, Paul Tapang, Daniel H. Albert, George M. Carrera, George S. Sheppard, Rhein Da

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:2913-2918

3-(3-Pyridinyl)-7-(indol-3-ylcarbonyl)-1H-3H-pyrrolo[1,2-c]thiazoles represent a class of potent, orally active PAF antagonists; however, the lead compounds in this series suffered from a lack of aqueous solubility. To overcome this limitation, a num

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56f13f4772af4862d22906eb73903181
https://doi.org/10.1016/0960-894x(95)00511-q

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Discovery and optimization of indole pyrrolothiazole paf antagonists

Autor: Terrance J. Magoc, Daisy Pireh, George S. Sheppard, H. Robin Heyman, Richard G. Conway, Douglas H. Steinman, James H. Holms, Steven K. Davidsen, Rhein Da, Gongjin Luo, George M. Carrera, Nichael L. Curtin, James B. Summers, Paul Tapang, Daniel H. Albert

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:2903-2908

3-(3-Pyridinyl)-7-(indol-3-ylcarbonyl)-1 H -3 H -pyrrolo[1,2-c]thiazoles represent a new class of platelet activating factor antagonists. This series was discovered by combining the indole portion of a previous thiazolidine series with the known 3-py

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::588d2ed92275742c29377dbac13be3ca
https://doi.org/10.1016/0960-894x(95)00509-r

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3-(2-(3-Pyridinyl)thiazolidin-4-oyl)indoles, a Novel Series of Platelet Activating Factor Antagonists

Autor: James G. Phillips, Mark G. Bures, Daisy Pireh, William C. Calhoun, Denise E. Guinn, Richard D. Conway, Steven K. Davidsen, T. J. Magoc, George M. Carrera, James B. Summers, Paul D. May, H. Robin Heyman, Rhein Da, Daniel H. Albert, George S. Sheppard, Douglas H. Steinman, George W. Carter

Publikováno v: Journal of Medicinal Chemistry. 37:2011-2032

(2RS,4R)-3-(2-(3-Pyridinyl)thiazolidin-4-oyl)indoles represent a new class of potent, orally active antagonists of platelet activating factor (PAF). The compounds were prepared by acylation of the magnesium or zinc salts of substituted indoles with (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b81fa45952a3a9f10163d3f89b3bdeb
https://doi.org/10.1021/jm00039a015

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ChemInform Abstract: Synthesis of N-Arylated Oxazolidinones via a Palladium-Catalyzed Cross-Coupling Reaction. Application to the Synthesis of the Antibacterial Agent Dup-721

Autor: Richard J. Sciotti, Marina A. Pliushchev, Paul E. Wiedeman, David Madar, Stevan W. Djuric, Jonathan Pease, Hana Kopecka, Daisy Pireh

Publikováno v: ChemInform. 32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8bcb431092a413dacee04e55b7c1698f
https://doi.org/10.1002/chin.200136126

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Studies in the synthesis of the thromboxane receptor antagonist EP 092 and its enantiomers

Autor: Daisy Pireh, Michael Clare, Robert Bruce Garland, Lydia Swenton, Patricia M. Finnegan, Masateru Miyano

Publikováno v: The Journal of Organic Chemistry. 55:5854-5861

An improved synthesis of EP 092 was developed. Resolution of an early intermediate was achieved by using butane-2(R), 3(R)-diol ketals. Both enantiomers of EP 092 were found to possess platelet aggregation inhibition activity, but the l enantiomer wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f24de65c03eed6a146921994e0183a1
https://doi.org/10.1021/jo00310a017

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Discovery and structure-activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors

Autor: Xiaofeng Li, Thomas W. von Geldern, Kenton L. Longenecker, James M. Trevillyan, Chunqiu Lai, Kent D. Stewart, Bradley J. Backes, Thomas H. Lubben, Daisy Pireh, Anita J Kempf-Grote, Hing L. Sham, Zhonghua Pei, David W A Beno, Stephen J. Ballaron

Publikováno v: Journal of medicinal chemistry. 50(8)

Dipeptidyl peptidase IV (DPP4) inhibitors are emerging as a new class of therapeutic agents for the treatment of type 2 diabetes. They exert their beneficial effects by increasing the levels of active glucagon-like peptide-1 and glucose-dependent ins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8928389905d050ffae5e4709d0eb7a96
https://pubmed.ncbi.nlm.nih.gov/17367123

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