Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Daisuke Watase"'
Autor:
Shotaro Goto, Shuichi Setoguchi, Daisuke Watase, Hirofumi Yamakawa, Ayano Yamada, Mitsuhisa Koga, Koichi Matsuo, Kazuhisa Matsunaga, Yoshiharu Karube, Jiro Takata
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Epidermal growth factor receptor (EGFR) inhibitors frequently cause severe skin rash as a side effect, which is a critical burden for patients who continuously receive drug treatments. Several recent clinical trials have shown that vitamin K
Externí odkaz:
https://doaj.org/article/8e5a8ad35f7e4f73afa7a366fb7ff542
Autor:
Erina Toki, Shotaro Goto, Shuichi Setoguchi, Kazuki Terada, Daisuke Watase, Hirofumi Yamakawa, Ayano Yamada, Mitsuhisa Koga, Kaori Kubota, Katsunori Iwasaki, Yoshiharu Karube, Kazuhisa Matsunaga, Jiro Takata
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Mitochondria generate energy through the action of the electron transport chain (ETC) and ATP synthase. Mitochondrial malfunction can lead to various disorders, including neurodegenerative diseases. Several reports have shown that menaquinon
Externí odkaz:
https://doaj.org/article/1c24714cc6734033aef9346130aa3dd7
Autor:
Daisuke Watase, Shuichi Setoguchi, Nami Nagata-Akaho, Shotaro Goto, Hirofumi Yamakawa, Ayano Yamada, Mitsuhisa Koga, Yoshiharu Karube, Kazuhisa Matsunaga, Jiro Takata
Publikováno v:
Molecules, Vol 27, Iss 9, p 2727 (2022)
The intestinal absorption of hydrophobic compounds is severely influenced by their transportation rate through the unstirred water layer in the intestinal lumen. A member of the vitamin E family, α-Tocotrienol (α-T3) has remarkable pharmacological
Externí odkaz:
https://doaj.org/article/39c12113ddab477dad8cebd2517471c0
Autor:
Hirofumi Yamakawa, Shuichi Setoguchi, Shotaro Goto, Daisuke Watase, Kazuki Terada, Nami Nagata-Akaho, Erina Toki, Mitsuhisa Koga, Kazuhisa Matsunaga, Yoshiharu Karube, Jiro Takata
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 758 (2021)
The first-choice drug for acute promyelocytic leukemia (APL), all-trans retinoic acid (ATRA), frequently causes drug-resistance and some adverse effects. Thus, an effective and safe agent for ATRA-resistant APL is needed. Menaquinone-4 (MK-4, vitamin
Externí odkaz:
https://doaj.org/article/f7dfada8c5ab4d1792ff24bb0e763734
Autor:
Kazuki Terada, Ayumi Murata, Erina Toki, Shotaro Goto, Hirofumi Yamakawa, Shuichi Setoguchi, Daisuke Watase, Mitsuhisa Koga, Jiro Takata, Kazuhisa Matsunaga, Yoshiharu Karube
Publikováno v:
Molecules, Vol 25, Iss 18, p 4206 (2020)
Schizophrenia is a severe, chronic mental illness characterized by delusions, hallucinations, negative symptoms, and cognitive dysfunction. Recently, several studies have demonstrated that the pathogenesis of schizophrenia involves mitochondrial dysf
Externí odkaz:
https://doaj.org/article/25bdee10529b436e9b26af85935fed2a
Autor:
Shuichi Setoguchi, Ryoji Hidaka, Nami Nagata-Akaho, Daisuke Watase, Mitsuhisa Koga, Kazuhisa Matsunaga, Yoshiharu Karube, Jiro Takata
Publikováno v:
Molecules, Vol 25, Iss 3, p 546 (2020)
The aim of this study was to develop a prodrug of ubiquinol-10 (UqH-10), the active form of ubiquinone-10 (Uq-10), for oral delivery. Bioavailability of UqH-10 is hampered by its high susceptibility to oxidation and water-insolubility. We prepared th
Externí odkaz:
https://doaj.org/article/03f8644d52c54d28bcbd0b8a9b3e7719
Autor:
Munechika Enjoji, Daisuke Watase, Kazuhisa Matsunaga, Mariko Kusuda, Nami Nagata-Akaho, Yoshiharu Karube, Jiro Takata
Publikováno v:
Diseases, Vol 3, Iss 3, Pp 150-158 (2015)
Recently, new therapeutics have been developed for hepatocellular carcinoma (HCC). However, the overall survival rate of HCC patients is still unsatisfactory; one of the reasons for this is the high frequency of recurrence after radical treatment. Co
Externí odkaz:
https://doaj.org/article/b21d9959a98e49b8930ed930e7d6e98e
Autor:
Akinori Haratake, Daisuke Watase, Takuya Fujita, Shuichi Setoguchi, Kazuhisa Matsunaga, Jiro Takata
Publikováno v:
Journal of Functional Foods, Vol 16, Iss , Pp 174-182 (2015)
A low collagen skin mice model was established and used to evaluate the effects of orally administered collagen peptide (CP) and glycine, alanine, and proline mixture (GAP) on the collagen content in the skin of mice. This model was established by fe
Externí odkaz:
https://doaj.org/article/2b39a9ff423c4f34899777a04fd3c442
Autor:
Shuichi Setoguchi, Daisuke Watase, Kazuhisa Matsunaga, Hirofumi Yamakawa, Shotaro Goto, Kazuki Terada, Kenji Ohe, Munechika Enjoji, Yoshiharu Karube, Jiro Takata
Publikováno v:
Molecules, Vol 23, Iss 7, p 1738 (2018)
Hepatocellular carcinoma (HCC) shows poor prognosis owing to its very frequent recurrence even after curative treatment. Thus, an effective and safe long-term chemopreventive agent is strongly in demand. Menahydroquinone-4 (MKH) is an active form of
Externí odkaz:
https://doaj.org/article/0392d46658b046b3be01a8423786fc95
Autor:
Mariko Hirano-Kusuda, Shuichi Setoguchi, Mitsuhisa Koga, Shotaro Goto, Ayano Yamada, Daisuke Watase, Nami Nagata-Akaho, Yoshiharu Karube, Kazuhisa Matsunaga, Jiro Takata
Publikováno v:
Pharmaceutical Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::990ae512f85944cb932de6fe07016263
https://doi.org/10.1007/s11095-023-03500-5
https://doi.org/10.1007/s11095-023-03500-5