Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Daisuke Tsuchimoto"'
Autor:
Sugako Oka, Julio Leon, Kunihiko Sakumi, Nona Abolhassani, Zijing Sheng, Daisuke Tsuchimoto, Frank M. LaFerla, Yusaku Nakabeppu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract 8-Oxoguanine (8-oxoG), a major oxidative base lesion, is highly accumulated in Alzheimer’s disease (AD) brains during the pathogenic process. MTH1 hydrolyzes 8-oxo-dGTP to 8-oxo-dGMP, thereby avoiding 8-oxo-dG incorporation into DNA. 8-Oxo
Externí odkaz:
https://doaj.org/article/2da47d76ddfd4f32a7a7bc3c676d5685
Autor:
Md Akram Hossain, Yunfeng Lin, Garrett Driscoll, Jia Li, Anne McMahon, Joshua Matos, Haichao Zhao, Daisuke Tsuchimoto, Yusaku Nakabeppu, Jianjun Zhao, Shan Yan
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The maintenance of genome integrity and fidelity is vital for the proper function and survival of all organisms. Recent studies have revealed that APE2 is required to activate an ATR-Chk1 DNA damage response (DDR) pathway in response to oxidative str
Externí odkaz:
https://doaj.org/article/ff517a80ae9b41a5bf0200d07756bebc
Autor:
Yukino Miyachi, Takayuki Fujii, Ryo Yamasaki, Daisuke Tsuchimoto, Kyoko Iinuma, Ayako Sakoda, Shoko Fukumoto, Takuya Matsushita, Katsuhisa Masaki, Noriko Isobe, Yusaku Nakabeppu, Jun-ichi Kira
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Multiple sclerosis (MS), the most prevalent inflammatory disease of the central nervous system (CNS), is characterized by damaged to myelin sheaths and oligodendrocytes. Because MS patients have variable clinical courses and disease severities, it is
Externí odkaz:
https://doaj.org/article/543075fd8a9a4863a32b53b50542e7de
Autor:
Yuichiro Koga, Daisuke Tsuchimoto, Yoshinori Hayashi, Nona Abolhassani, Yasuto Yoneshima, Kunihiko Sakumi, Hiroshi Nakanishi, Shinya Toyokuni, Yusaku Nakabeppu
Publikováno v:
JCI Insight, Vol 5, Iss 22 (2020)
Inosine triphosphate pyrophosphatase (ITPA) hydrolyzes inosine triphosphate (ITP) and other deaminated purine nucleotides to the corresponding nucleoside monophosphates. In humans, ITPA deficiency causes severe encephalopathy with epileptic seizure,
Externí odkaz:
https://doaj.org/article/793d102ea4d64f4688334a0405926bb9
Autor:
Shinji Asada, Eiko Ohta, Yoriko Akimoto, Nona Abolhassani, Daisuke Tsuchimoto, Yusaku Nakabeppu
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract 2-Oxoadenosine (2-oxo-Ado), an oxidized form of adenosine, is cytotoxic and induces growth arrest and cell death, which has potential as an anti-cancer drug. However, it is not well understood how 2-oxo-Ado exerts its cytotoxicity. We examin
Externí odkaz:
https://doaj.org/article/8f2b2ee957cb4c88b21e8bfbbc8767d9
Autor:
Carol E. Schrader, Travis Williams, Klaus Pechhold, Erin K. Linehan, Daisuke Tsuchimoto, Yusaku Nakabeppu
Publikováno v:
The Journal of Immunology. 210:1804-1814
Somatic hypermutation (SHM) is necessary for Ab diversification and involves error-prone DNA repair of activation-induced cytidine deaminase–induced lesions in germinal center (GC) B cells but can also cause genomic instability. GC B cells express
Autor:
Jianjun Zhao, Jianhong Lin, Nikhil C. Munshi, Leal C. Herlitz, Kenneth C. Anderson, Thomas LaFramboise, Shan Yan, Jennifer S. Yu, Qing Y. Zheng, Xin Qi, Jack Khouri, Faiz Anwer, Alex Mejia-Garcia, Xiaofeng Jiang, Yusaku Nakabeppu, Daisuke Tsuchimoto, Allison J. Janocha, Mei Yin, Hua Fang, Ariel Kwart, Li Xue, Chuanfeng Fang, Chen Li, Jenny Lin, Mohsin Maqbool, Tania Amorim, Chun Yang, Yi Hu
Cisplatin chemotherapy is standard care for many cancers but is toxic to the kidneys. How this toxicity occurs is uncertain. In this study, we identified apurinic/apyrimidinic endonuclease 2 (APE2) as a critical molecule upregulated in the proximal t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69c548fdce336a19f7a551f3394fb843
https://doi.org/10.1158/0008-5472.c.6512529.v1
https://doi.org/10.1158/0008-5472.c.6512529.v1
Autor:
Jianjun Zhao, Jianhong Lin, Nikhil C. Munshi, Leal C. Herlitz, Kenneth C. Anderson, Thomas LaFramboise, Shan Yan, Jennifer S. Yu, Qing Y. Zheng, Xin Qi, Jack Khouri, Faiz Anwer, Alex Mejia-Garcia, Xiaofeng Jiang, Yusaku Nakabeppu, Daisuke Tsuchimoto, Allison J. Janocha, Mei Yin, Hua Fang, Ariel Kwart, Li Xue, Chuanfeng Fang, Chen Li, Jenny Lin, Mohsin Maqbool, Tania Amorim, Chun Yang, Yi Hu
Table S1: MS/MS analyses of APE2 pull-down proteins in 293T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c6efe40ba6f69c464abb12c56c0cade
https://doi.org/10.1158/0008-5472.22427040.v1
https://doi.org/10.1158/0008-5472.22427040.v1
Autor:
Jianjun Zhao, Jianhong Lin, Nikhil C. Munshi, Leal C. Herlitz, Kenneth C. Anderson, Thomas LaFramboise, Shan Yan, Jennifer S. Yu, Qing Y. Zheng, Xin Qi, Jack Khouri, Faiz Anwer, Alex Mejia-Garcia, Xiaofeng Jiang, Yusaku Nakabeppu, Daisuke Tsuchimoto, Allison J. Janocha, Mei Yin, Hua Fang, Ariel Kwart, Li Xue, Chuanfeng Fang, Chen Li, Jenny Lin, Mohsin Maqbool, Tania Amorim, Chun Yang, Yi Hu
Normal morphology in other organs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527efc0befa9c38d9a322ad12825ad79
https://doi.org/10.1158/0008-5472.22427046
https://doi.org/10.1158/0008-5472.22427046
Autor:
Daisuke Tsuchimoto, Hiroshi Morioka, Takahiro Imaizumi, Sawako Miyagawa, Masashi Yamamoto, Katsuhiro Onishi, Yukinori Kuwabara, Kazuto Takada, Koichi Watamoto
Publikováno v:
Biologicalpharmaceutical bulletin. 45(9)
This study aimed to clarify the details of outpatient oral antimicrobial use (AMU) at a Japanese community hospital and investigate the influence of the current inpatient-based antimicrobial stewardship (AS) on outpatients. A repeated cross-sectional