Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Daisuke Shinmi"'
Autor:
Daisuke Shinmi, Ryosuke Nakano, Keisuke Mitamura, Minami Suzuki‐Imaizumi, Junko Iwano, Yuya Isoda, Junichi Enokizono, Yasuhisa Shiraishi, Emi Arakawa, Kazuma Tomizuka, Kazuhiro Masuda
Publikováno v:
Cancer Medicine, Vol 6, Iss 4, Pp 798-808 (2017)
Abstract Carcinoembryonic antigen (CEA) is a classic tumor‐specific antigen that is overexpressed in several cancers, including gastric cancer. Although some anti‐CEA antibodies have been tested, to the best of our knowledge, there are currently
Externí odkaz:
https://doaj.org/article/bb89aaf8f1514e1dadc670cc4bef52df
Publikováno v:
Drug Metabolism and Disposition. 51:338-347
Publikováno v:
Drug Metabolism and Disposition. 47:1240-1246
Carcinoembryonic antigen (CEA) is a tumor-specific antigen overexpressed in multiple cancers. CEA is expressed as a membrane protein, a part of which is cleaved from the cell membrane and secreted into blood. The soluble form of CEA (sCEA) has been s
Autor:
Daisuke Shinmi, Emiko Honma, Motoo Yamasaki, Takashige Muramoto, Kazuhiro Masuda, Yasuhisa Shiraishi, Kazutaka Nagatomo
Publikováno v:
Bioconjugate Chemistry. 26:1032-1040
Engineered cysteine residues are currently used for the site-specific conjugation of antibody-drug conjugates (ADC). In general, positions on the protein surface have been selected for substituting a cysteine as a conjugation site; however, less expo
Autor:
Junichi Enokizono, Emi Arakawa, Ryosuke Nakano, Junko Iwano, Kazuhiro Masuda, Daisuke Shinmi, Keisuke Mitamura, Yuya Isoda, Minami Suzuki-Imaizumi, Yasuhisa Shiraishi, Kazuma Tomizuka
Publikováno v:
Cancer Medicine
Carcinoembryonic antigen (CEA) is a classic tumor‐specific antigen that is overexpressed in several cancers, including gastric cancer. Although some anti‐CEA antibodies have been tested, to the best of our knowledge, there are currently no clinic
Autor:
Yasuhisa Shiraishi, Junko Iwano, Daisuke Shinmi, Kazuhiro Masuda, Tsuyoshi Yamaguchi, Junichi Enokizono, Eri Taguchi
Publikováno v:
Bioconjugate chemistry. 27(5)
Engineered cysteine residues are particularly convenient for site-specific conjugation of antibody-drug conjugates (ADC), because no cell engineering and additives are required. Usually, unpaired cysteine residues form mixed disulfides during ferment
Autor:
Kazuhiro Motoki, Taro Tamada, Masahiro Ikeda, Daisuke Shinmi, Eiji Mori, Shiro Kataoka, Yasushi Yonezawa, Ryota Kuroki
Publikováno v:
Scientific Reports
The fully human monoclonal antibody KMTR2 acts as a strong direct agonist for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor 2 (TRAIL-R2), which is capable of inducing apoptotic cell death without cross-linking. To investiga
Publikováno v:
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 128(32):10452-10459
To accomplish the selective labeling of a specific protein in complicated biological systems, a peptide tag incorporated into the protein and a complementary small molecular probe are required. Although a variety of peptide tag/probe pairs have been
Genetically encoded fluorescent thermosensors visualize subcellular thermoregulation in living cells
Autor:
Takenao Yoshizaki, Taketoshi Kajimoto, Reiko Sakaguchi, Hiroshi Matsuura, Yasuo Mori, Takashi Morii, Shigeki Kiyonaka, Daisuke Shinmi, Mariko Omatsu-Kanbe, Hiromi Imamura, Itaru Hamachi
Publikováno v:
Nature methods. 10(12)
In mammals and birds, thermoregulation to conserve body temperature is vital to life. Multiple mechanisms of thermogeneration have been proposed, localized in different subcellular organelles. However, visualizing thermogenesis directly in intact org
Autor:
Daisuke Shinmi, Kimihisa Ichikawa, Koichi Nonaka, Haruhiko Tsumura, Kazuo Kobayashi, Yasunori Chiba, Eiji Mori, Yoshifumi Jigami, Teruyuki Sakai, Toshihiro Komeda, Kazumi Fuju, Takeshi Suzuki, Kousuke Kuroda, Yoshinori Kitagawa, Taishiro Nakagawa, Kazuhiro Motoki
Publikováno v:
Applied and environmental microbiology. 74(2)
When antibodies were expressed in the methylotrophic yeast Ogataea minuta , we found that abnormal O mannosylation occurred in the secreted antibody. Yeast-specific O mannosylation is initiated by the addition of mannose at serine (Ser) or threonine