Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Daisuke Shigeoka"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 860-865 (2013)
An iron(II)-mediated aminohalogenation of a cyclopentenyl N-tosyloxycarbamate provided new access to the key intermediate for the synthesis of (−)-agelastatin A (AA, 1), a potent antiproliferative alkaloid. The present synthetic endeavour offered a
Externí odkaz:
https://doaj.org/article/5a3e4159b4e24dd18a353894544450fd
Publikováno v:
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 860-865 (2013)
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 860-865 (2013)
An iron(II)-mediated aminohalogenation of a cyclopentenyl N-tosyloxycarbamate provided new access to the key intermediate for the synthesis of (−)-agelastatin A (AA, 1), a potent antiproliferative alkaloid. The present synthetic endeavour offered a
Publikováno v:
Organic letters. 17(1)
A new synthetic route to clavilactone B, a naturally occurring inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, is disclosed. The route features a sequential samarium-mediated radical cyclization–fragmentation of an indanone de
Publikováno v:
ChemInform. 43
Treatment of allyl N-tosyloxycarbamates with Bu4NBr and FeBr2 results in formation of β-brominated oxazolidinones.
Autor:
Masayoshi Arai, Han W. Tun, Takuma Kamon, Thomas R. Caulfield, Yushi Qiu, Daisuke Shigeoka, Takashi Kawachi, Zhimin Li, Takehiko Yoshimitsu
Publikováno v:
MedChemComm. 4:1093
(−)-Agelastatin A (AA), isolated from the coral sea axinellid sponge Agelas dendromorpha, has shown a high antineoplastic activity. We have synthesized eighteen AA analogues and analyzed their cytotoxicities towards three cancer cell lines. By the
Publikováno v:
Organic & Biomolecular Chemistry. 10:2363
Allyl N-tosyloxycarbamates are found to be catalytically transformed into β-brominated oxazolidinones with FeBr(2)/n-Bu(4)NBr in t-BuOH.