Výsledky vyhledávání - "Daisuke Okajima"

Abstract 2932: Datopotamab deruxtecan (Dato-DXd) enhances antitumor response to PD-1/PD-L1 inhibitors in TROP2-expressing tumors in mice

Autor: Daisuke Okajima, Satoru Yasuda, Takami Suzuki, Michiko Kitamura, Junko Yamaguchi, Takanori Maejima, Tsuyoshi Karibe, Tadashi Toki, Penny Phillips, Toshinori Agatsuma

Publikováno v: Cancer Research. 83:2932-2932

Background: Trophoblast cell surface antigen 2 (TROP2) is highly expressed in various epithelial tumors, including non-small cell lung cancer (NSCLC) and triple negative breast cancer (TNBC), and correlates with poor prognosis. Datopotamab deruxtecan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5657bb755ef7276704e9385af76187e0
https://doi.org/10.1158/1538-7445.am2023-2932

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Abstract A027: Combination of TROP2 and SLFN11 as the sensitivity biomarkers for DS-1062a, a novel TROP2-targeting antibody-drug conjugate with a novel DNA topoisomerase I inhibitor DXd

Autor: Satoru Yasuda, Tomomichi Fujitani, Junko Yamaguchi, Masato Murakami, Tadashi Toki, Tsuyoshi Karibe, Daisuke Okajima, Yutaka Noguchi, Takashi Nakada

Publikováno v: Molecular Cancer Therapeutics. 18:A027-A027

Background: DS-1062a is a TROP2-targeting antibody-drug conjugate with Daiichi-Sankyo DXd technology. DS-1062a is expected to deliver DXd, a derivative of Exatecan, to TROP2 highly expressed tumors such as epithelial cancers with stronger anti-tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81e19e961996d59a05241f791f232cc4
https://doi.org/10.1158/1535-7163.targ-19-a027

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Abstract C026: DS-1062a, a novel TROP2-targeting antibody-drug conjugate with a novel DNA topoisomerase I inhibitor DXd, demonstrates potent antitumor activity in preclinical models

Autor: Reiko Kamei, Daisuke Okajima, Yuki Abe, Tomoko Shibutani, Tomomichi Fujitani, Junko Yamaguchi, Takashi Nakada, Toshinori Agatsuma, Takanori Maejima, Riki Goto, Tadashi Toki, Tsuyoshi Karibe, Yutaka Noguchi, Michiko Kitamura, Satoru Yasuda

Publikováno v: Molecular Cancer Therapeutics. 18:C026-C026

Background: A trophoblast cell surface antigen 2 (TROP2) is a 36-kDa single-pass transmembrane protein overexpressed in various epithelial tumors including non-small cell lung cancer (NSCLC) with relatively low and restricted expression in normal tis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e64148ac06d2c67a0618f656f13c1f6
https://doi.org/10.1158/1535-7163.targ-19-c026

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First-in-human phase 1 study of DS-1062a in patients with advanced solid tumors

Autor: Noboru Yamamoto, Jacob Sands, Alexander I. Spira, Aaron Lisberg, Jonathan Greenberg, Yutaka Noguchi, Edward B. Garon, F. Guevara, Rebecca S. Heist, Toshio Shimizu, Daisuke Okajima, Naoyuki Tajima, Fumiaki Kobayashi

Publikováno v: Journal of Clinical Oncology. 37:9051-9051

9051 Background: DS-1062a is a trophoblast cell-surface antigen 2 (TROP2)-targeting antibody drug conjugate. TROP2 is highly expressed in epithelial cancers, including non-small cell lung cancer (NSCLC). Overexpression of TROP2 may be associated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e1256ef2313022e258936a34d7d0a08
https://doi.org/10.1200/jco.2019.37.15_suppl.9051

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Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing

Autor: Daisuke Okajima, Gen Kudo, Hiroshi Yokota

Publikováno v: Journal of Receptors and Signal Transduction. 30:143-153

Brain-specific angiogenesis inhibitor 2 (BAI2) is a member of adhesion-G protein-coupled receptors (GPCRs). BAI2 is dominantly expressed in the brain and its physiological ligands and functions are still unclear. Adhesion-GPCRs, including BAI2, commo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19857863dc8a6253c536daa3a0e7516e
https://doi.org/10.3109/10799891003671139

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A STUDY ON THE PROVIDING THE INFORMATION TO MAKE INHABITANTS UNDERSTAND THE REFUGE INFORMATION AT THE TIME OF A FLOOD

Autor: Daisuke Okajima, Junsaku Asada, Toshitaka Katada, Shigeki Kobatake

Publikováno v: PROCEEDINGS OF HYDRAULIC ENGINEERING. 45:37-42

A first priority on crisis management during a natural disaster is to minimize or to mitigate casualties. Therefore refuge information should be transmitted to inhabitants effectively so as to help them understand the situation exactly and to select

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3271b7eb543439769a0e1aabe6c61ed0
https://doi.org/10.2208/prohe.45.37

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