Zobrazeno 1 - 10
of 423
pro vyhledávání: '"Daisuke, Koya"'
Publikováno v:
Journal of Diabetes Investigation, Vol 14, Iss 7, Pp 844-855 (2023)
ABSTRACT Aims/Introduction Linagliptin is a selective dipeptidyl peptidase (DPP)‐4 inhibitor capable of successfully regulating blood glucose levels. The cardiovascular protective effects of several DPP‐4 inhibitors have been shown in preclinical
Externí odkaz:
https://doaj.org/article/37d38c41c0374564b926b036200aabbd
Autor:
Keiji Shimada, Keizo Kanasaki, Makoto Kato, Yoshio Ogura, Yuta Takagaki, Itaru Monno, Taro Hirai, Munehiro Kitada, Daisuke Koya
Publikováno v:
Journal of Diabetes Investigation, Vol 13, Iss 6, Pp 955-964 (2022)
Abstract Aims/Introduction Sodium–glucose cotransporter 2 inhibitors (SGLT2i) have been shown to display excellent renoprotective effects in diabetic kidney disease with macroalbuminuria/proteinuria. Regarding the renoprotective mechanism of SGLT2i
Externí odkaz:
https://doaj.org/article/0b184aa20b184b93b6ab0ac42f9c8f01
Autor:
Taro Hirai, Munehiro Kitada, Itaru Monno, Erina Oda, Yoshihiro Hayashi, Keiji Shimada, Yuta Takagaki, Yoshio Ogura, Mizue Fujii, Kazunori Konishi, Masaru Sakurai, Atsushi Nakagawa, Daisuke Koya
Publikováno v:
Journal of Diabetes Investigation, Vol 12, Iss 9, Pp 1577-1585 (2021)
Abstract Aims/Introduction The aim of this study was to elucidate whether sodium–glucose cotransporter 2 inhibitors (SGLT2is) treatment has any renoprotective effect for type 2 diabetes mellitus patients with an estimated glomerular filtration rate
Externí odkaz:
https://doaj.org/article/b15014c99b144c01b71d312f5adb526f
Publikováno v:
Journal of Diabetes Investigation, Vol 12, Iss 5, Pp 697-709 (2021)
Abstract Aims/Introduction Tubulointerstitial fibrosis is a hallmark of diabetic nephropathy and is associated with an epithelial‐to‐mesenchymal transition (EMT) program and aberrant glycolysis. Dimeric pyruvate kinase (PK) M2 (PKM2) acts as a ke
Externí odkaz:
https://doaj.org/article/939aaa1251814c218872d610d5bde843
Autor:
Swayam Prakash Srivastava, Han Zhou, Ocean Setia, Bing Liu, Keizo Kanasaki, Daisuke Koya, Alan Dardik, Carlos Fernandez-Hernando, Julie Goodwin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The endothelial glucocorticoid receptor plays a key role in the regulation of many diseases, including diabetes. Loss of this receptor results in accelerated renal fibrosis, a heightened inflammatory milieu, augmented Wnt signaling and suppression of
Externí odkaz:
https://doaj.org/article/f93663ef9d3e4bd39f4587ef786d5886
Autor:
Kenichi Shikata, Masakazu Haneda, Toshiharu Ninomiya, Daisuke Koya, Yoshiki Suzuki, Daisuke Suzuki, Hitoshi Ishida, Hiroaki Akai, Yasuhiko Tomino, Takashi Uzu, Motonobu Nishimura, Shiro Maeda, Daisuke Ogawa, Satoshi Miyamoto, Hirofumi Makino, the Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT‐Japan) collaborative group
Publikováno v:
Journal of Diabetes Investigation, Vol 12, Iss 2, Pp 207-216 (2021)
Abstract Aims/Introduction We evaluated the efficacy of multifactorial intensive treatment (IT) on renal outcomes in patients with type 2 diabetes and advanced‐stage diabetic kidney disease (DKD). Materials and Methods The Diabetic Nephropathy Remi
Externí odkaz:
https://doaj.org/article/008af3b142f74ab5b7527d7cf61aa3eb
Autor:
Yuiko Mizunuma, Keizo Kanasaki, Kyoko Nitta, Yuka Nakamura, Yasuhito Ishigaki, Yuta Takagaki, Munehiro Kitada, Shaolan Li, Haijie Liu, Jinpeng Li, Isao Usui, Yoshimasa Aso, Daisuke Koya
Publikováno v:
Journal of Diabetes Investigation, Vol 11, Iss 6, Pp 1470-1481 (2020)
Abstract Aims/Introduction To establish novel therapies to combat diabetic kidney disease, a human disease‐relevant animal model is essential. However, a type 2 diabetic mouse model presenting progressive kidney fibrosis has not yet been establishe
Externí odkaz:
https://doaj.org/article/d22e85eb36dd4f09a088a6c5e1641441
Autor:
Taro Hirai, Munehiro Kitada, Yoshihiro Hayashi, Itaru Monno, Yuta Takagaki, Keiji Shimada, Yoshio Ogura, Mizue Fujii, Kazunori Konishi, Atsushi Nakagawa, Daisuke Koya
Publikováno v:
Journal of Diabetes Investigation, Vol 11, Iss 5, Pp 1359-1362 (2020)
Abstract A 58‐year‐old women who was diagnosed with type 2 diabetes 20 years earlier had been treated with antidiabetic medicines since she was aged 40 years. After sodium–glucose cotransporter 2 inhibitors administration, her bodyweight rapidl
Externí odkaz:
https://doaj.org/article/7b3332833085472ea452eefe24ff0be1
Autor:
Kenichi Shikata, Ryo Kodera, Kazunori Utsunomiya, Daisuke Koya, Rimei Nishimura, Satoshi Miyamoto, Naoko Tajima, the JDCP study group
Publikováno v:
Journal of Diabetes Investigation, Vol 11, Iss 2, Pp 325-332 (2020)
Abstract Aims/Introduction To clarify the prevalence of albuminuria and renal dysfunction, and related factors in Japanese patients with diabetes, we analyzed the baseline data of the Japan Diabetes Complication and its Prevention prospective study.
Externí odkaz:
https://doaj.org/article/2b601da3c1054b1c9ff934c8cc14ce8c
Publikováno v:
Cells, Vol 12, Iss 4, p 595 (2023)
Aging is a major risk factor for the leading causes of mortality, and the incidence of age-related diseases including cardiovascular disease, kidney disease and metabolic disease increases with age. NAD+ is a classic coenzyme that exists in all speci
Externí odkaz:
https://doaj.org/article/f8443d41f3ad4ac8bc99d85a30f653f6