Zobrazeno 1 - 10 of 87 pro vyhledávání: '"Daisuke, Ishibashi"'
1
Akademický článek
Preparation of siRNA–PLGA/Fabʹ–PLGA mixed micellar system with target cell-specific recognition
Autor: Mai Hazekawa, Takuya Nishinakagawa, Takeshi Mori, Miyako Yoshida, Takahiro Uchida, Daisuke Ishibashi
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Small interfering RNAs (siRNAs) are susceptible to nucleases and degrade quickly in vivo. Moreover, siRNAs demonstrate poor cellular uptake and cannot cross the cell membrane because of its polyanionic characteristics. To overcome these chal
Externí odkaz: https://doaj.org/article/9b11b42a60154855a4a1652ebfdb9cd5
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2
Akademický článek
Development of an Organ-Directed Exosome-Based siRNA-Carrier Derived from Autologous Serum for Lung Metastases and Testing in the B16/BL6 Spontaneous Lung Metastasis Model
Autor: Mai Hazekawa, Takuya Nishinakagawa, Masato Hosokawa, Daisuke Ishibashi
Publikováno v: Pharmaceutics, Vol 14, Iss 4, p 815 (2022)
Exosomes are nano-sized extracellular vesicles that are known to carry various messages to distant cells. It was recently reported that cancer-derived exosomes are orientated to metastatic organs. However, there are no reports on drug carrier develop
Externí odkaz: https://doaj.org/article/171b0ac2d5a74b27ac46b186669e9cfa
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3
Akademický článek
Structure-Based Drug Discovery for Prion Disease Using a Novel Binding Simulation
Autor: Daisuke Ishibashi, Takehiro Nakagaki, Takeshi Ishikawa, Ryuichiro Atarashi, Ken Watanabe, Felipe A. Cruz, Tsuyoshi Hamada, Noriyuki Nishida
Publikováno v: EBioMedicine, Vol 9, Iss C, Pp 238-249 (2016)
The accumulation of abnormal prion protein (PrPSc) converted from the normal cellular isoform of PrP (PrPC) is assumed to induce pathogenesis in prion diseases. Therefore, drug discovery studies for these diseases have focused on the protein conversi
Externí odkaz: https://doaj.org/article/96bb003f01b6421bb9a83ff818160568
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5
Dextran sulphate inhibits an association of prions with plasma membrane at the early phase of infection
Autor: Noriyuki Nishida, Naohiro Yamaguchi, Takujiro Homma, Daisuke Ishibashi, Hiroya Tange, Takayuki Fuse, Takehiro Nakagaki, Ryuichiro Atarashi
Publikováno v: Neuroscience Research. 171:34-40
The defining characteristic of prion diseases is conversion of a cellular prion protein (PrPC) to an abnormal prion protein (PrPSc). The exogenous attachment of PrPSc to the surface of a target cell is critical for infection. However, the initial int
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1f39dd070769904774e969f01c941d3
https://doi.org/10.1016/j.neures.2021.01.004
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6
Preparation of siRNA–PLGA/Fabʹ–PLGA mixed micellar system with target cell-specific recognition
Autor: Takuya Nishinakagawa, Mai Hazekawa, Takahiro Uchida, Daisuke Ishibashi, Takeshi Mori, Miyako Yoshida
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Small interfering RNAs (siRNAs) are susceptible to nucleases and degrade quickly in vivo. Moreover, siRNAs demonstrate poor cellular uptake and cannot cross the cell membrane because of its polyanionic characteristics. To overcome these challenges, a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc2c622c494441d8c9a45b01a23b2f0
https://doaj.org/article/9b11b42a60154855a4a1652ebfdb9cd5
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7
Novel Compounds Identified by Structure-Based Prion Disease Drug Discovery Using In Silico Screening Delay the Progression of an Illness in Prion-Infected Mice
Autor: Daisuke Ishibashi, Takeshi Ishikawa, Satoshi Mizuta, Noriyuki Nishida, Takehiro Nakagaki, Hiroya Tange, Tsuyoshi Hamada
Publikováno v: Neurotherapeutics
The accumulation of abnormal prion protein (PrP(Sc)) produced by the structure conversion of PrP (PrP(C)) in the brain induces prion disease. Although the conversion process of the protein is still not fully elucidated, it has been known that the int
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5accb375fe14c0d9f72bc85c195cb126
https://doi.org/10.1007/s13311-020-00903-9
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10
Akademický článek
Comparison of Single- and Repeated-Ischemia-Induced Changes in Expression of Flip and Flop Splice Variants of AMPA Receptor Subtypes GluR1 and GluR2 in the Rats Hippocampus CA1 Subregion
Autor: Izzettin Hatip-Al-Khatib, Katsunori Iwasaki, Nobuaki Egashira, Daisuke Ishibashi, Kenichi Mishima, Michihiro Fujiwara
Publikováno v: Journal of Pharmacological Sciences, Vol 103, Iss 1, Pp 83-91 (2007)
In addition to their role in physiological activities, ionotropic glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors (AMPARs) play an important role in neuronal death, especially that following ischemic insults. In this study, we
Externí odkaz: https://doaj.org/article/f9b5854f2341455ea28bf518b10c387d
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