A Pooled Analysis of Eight Clinical Studies Suggests a Link Between Influenza-Like Symptoms and Pharmacodynamics of the Toll-Like Receptor-7 Agonist Vesatolimod

Autor: Sharon A. Riddler, Constance A. Benson, Cynthia Brinson, Steven G. Deeks, Edwin DeJesus, Anthony Mills, Michael F. Para, Moti N. Ramgopal, Yanhui Cai, Yanan Zheng, Liao Zhang, Wendy Jiang, Xiaopeng Liu, Donovan Verrill, Daina Lim, Christiaan R. de Vries, Jeffrey J. Wallin, Elena Vendrame, Devi SenGupta

Publikováno v: Infectious Diseases and Therapy, Vol 13, Iss 11, Pp 2285-2299 (2024)

Abstract Introduction Vesatolimod is a Toll-like receptor-7 (TLR7) agonist in clinical development as part of a combination regimen for human immunodeficiency virus (HIV) cure. Influenza-like symptoms associated with TLR7-mediated immune activation h

Externí odkaz: https://doaj.org/article/120544d7e17c45da8a0447d59666d1f3

Immunopathologies linked to integrin signalling

Autor: Hongyan Wang, Christopher E. Rudd, Daina Lim

Publikováno v: Seminars in Immunopathology. 32:173-182

Integrin binding to ligand plays essential roles in the differentiation and function of mammalian cells. beta2 integrins in leukocytes are needed for migration to sites of inflammation and in lymph nodes as well as for cellular events such as phagocy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3202ca6713d19fd4ce96df9c4bd7e5e0
https://doi.org/10.1007/s00281-010-0202-3

Non-cleavable talin rescues defect in the T-cell conjugation of T-cells deficient in the immune adaptor SKAP1

Autor: Daina, Lim, Yuning, Lu, Christopher E, Rudd

Publikováno v: Immunology Letters

Highlights • Skap1−/− T-cells show impaired talin and RIAM localization at the anti-CD3 beads. • Talin cleavage is altered in Skap1−/− T-cells. • Cleavage resistant talin (L432G) restored normal conjugation of Skap1−/− T-cells. •

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d45ca264ee27ab27c28ee5635d543d11
https://pubmed.ncbi.nlm.nih.gov/26905930

Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors

Autor: Lei Han, Hongyan Wang, Andrew M. L. Lever, Clare Jolly, Daina Lim, Truus E.M. Abbink, Rongrong Zhai, Wei Gao, Youg Raj Thaker, Jianhua Wang, Christopher E. Rudd, Bin Wei, Elisabetta Groppelli

Publikováno v: Wei, B, Han, L, Abbink, T E M, Groppelli, E, Lim, D, Thaker, Y R, Gao, W, Zhai, R, Wang, J, Lever, A, Jolly, C, Wang, H & Rudd, C E 2013, ' Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors ', Retrovirology, vol. 10, no. 1, 101 . https://doi.org/10.1186/1742-4690-10-101
Retrovirology, 10(1):101. BioMed Central
Retrovirology
Europe PubMed Central

Background Immune cell adaptor protein ADAP (adhesion and degranulation-promoting adaptor protein) mediates aspects of T-cell adhesion and proliferation. Despite this, a connection between ADAP and infection by the HIV-1 (human immunodeficiency virus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c043054eb17f4f51228a95550f552d05
https://research.vumc.nl/en/publications/715e4a6b-5ed2-4e9d-8ec6-d673d3f02c56

Applications of RNAi Technology

Autor: Daina Lim, Boon-Huat Bay, George W. Yip

Publikováno v: Natural Products: Essential Resources for Human Survival

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76a2697c84f23ecbb9ca5e8403ced35c
https://doi.org/10.1142/9789812707444_0003