Gene regulatory mechanisms underlying microglial dysfunction in Alzheimer's disease

Autor: Daily, Kylene Patricia

The projects described within address a knowledge gap regarding specific epigenetic regulatory mechanisms underlying the dysfunction of microglia in Alzheimer’s disease. AD is the 6th leading cause of death in the US. Of the top 10 causes of death,

Externí odkaz: http://rave.ohiolink.edu/etdc/view?acc_num=osu164994661205995

DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer’s disease.

Autor: Daily, Kylene P.¹ (AUTHOR), Badr, Asmaa^1,2 (AUTHOR), Eltobgy, Mostafa¹ (AUTHOR), Estfanous, Shady^1,3 (AUTHOR), Whitham, Owen¹ (AUTHOR), Tan, Michelle H.¹ (AUTHOR), Carafice, Cierra¹ (AUTHOR), Krause, Kathrin^1,4 (AUTHOR), McNamara, Andrew¹ (AUTHOR), Hamilton, Kaitlin¹ (AUTHOR), Houle, Samuel⁵ (AUTHOR), Gupta, Spandan¹ (AUTHOR), Gupta, Gauruv A.¹ (AUTHOR), Madhu, Shruthi¹ (AUTHOR), Fitzgerald, Julie⁵ (AUTHOR), Saadey, Abbey A.¹ (AUTHOR), Laster, Brooke¹ (AUTHOR), Yan, Pearlly⁶ (AUTHOR), Webb, Amy⁷ (AUTHOR), Zhang, Xiaoli⁸ (AUTHOR)

Publikováno v: Alzheimer's Research & Therapy. 2/8/2024, Vol. 16 Issue 1, p1-20. 20p.

Methylomic correlates of autophagy activity in cystic fibrosis

Autor: Caution, Kyle, Pan, Alexander, Krause, Kathrin, Badr, Asmaa, Hamilton, Kaitlin, Vaidya, Anup, Gosu, Hawin, Daily, Kylene, Estfanous, Shady, Gavrilin, Mikhail A., Drew, Mark E., Cormet-Boyaka, Estelle, Chen, Xi, Frankhouser, David E., Bundschuh, Ralf, Yan, Pearlly, Dakhlallah, Duaa, Amer, Amal O.

Publikováno v: In Journal of Cystic Fibrosis July 2019 18(4):491-500

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