Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Dailu Chen"'
Autor:
Dailu Chen, Sofia Bali, Ruhar Singh, Aleksandra Wosztyl, Vishruth Mullapudi, Jaime Vaquer-Alicea, Parvathy Jayan, Shamiram Melhem, Harro Seelaar, John C. van Swieten, Marc I. Diamond, Lukasz A. Joachimiak
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
The authors used multi-disciplinary approaches to understand the structural mechanism underlying spontaneous aggregation of tau encoding an S320F FTD-tau mutant. Understanding the mechanisms of tau aggregation will help identify novel methods to regu
Externí odkaz:
https://doaj.org/article/b84963259f3d4cf7b3feeba89b86ffa0
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Pathogenesis of tauopathies involves conversion of tau monomer into pathological tau conformers that serve as templates to recruit native tau into growing assemblies. Small soluble tau seeds have been proposed to drive pathological tau assem
Externí odkaz:
https://doaj.org/article/3a52c751ad3f486f923d73a2de32d49c
Autor:
Dailu Chen, Kenneth W. Drombosky, Zhiqiang Hou, Levent Sari, Omar M. Kashmer, Bryan D. Ryder, Valerie A. Perez, DaNae R. Woodard, Milo M. Lin, Marc I. Diamond, Lukasz A. Joachimiak
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The biophysical mechanisms of how disease-associated tau mutations drive amyloid formation are not well understood. Here the authors use biophysical approaches, cell models and MD simulations and find that the intrinsically disordered repeat domain o
Externí odkaz:
https://doaj.org/article/03b30e34ee8f4915b39c71a3c1b8c803
Autor:
Hilda Mirbaha, Dailu Chen, Olga A Morazova, Kiersten M Ruff, Apurwa M Sharma, Xiaohua Liu, Mohammad Goodarzi, Rohit V Pappu, David W Colby, Hamid Mirzaei, Lukasz A Joachimiak, Marc I Diamond
Publikováno v:
eLife, Vol 7 (2018)
Tauopathies feature progressive accumulation of tau amyloids. Pathology may begin when these amplify from a protein template, or seed, whose structure is unknown. We have purified and characterized distinct forms of tau monomer—inert (Mi) and seed-
Externí odkaz:
https://doaj.org/article/4a281ab9d29a4287a093526308f4f1c5
Autor:
Dailu Chen, Lukasz A. Joachimiak
Publikováno v:
Methods in Molecular Biology ISBN: 9781071625965
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5b613f88cff2beb181a8f0846680c30
https://doi.org/10.1007/978-1-0716-2597-2_13
https://doi.org/10.1007/978-1-0716-2597-2_13
Autor:
Dailu, Chen, Lukasz A, Joachimiak
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2551
Protein assembly into beta-sheet-rich amyloids is a common phenomenon in neurodegenerative diseases including Alzheimer's (AD) and Parkinson's (PD). The proteins implicated in amyloid deposition are often intrinsically disordered proteins (IDPs) and
Autor:
Dailu Chen, Aleksandra Wosztyl, Vishruth Mullapudi, Sofia Bali, Jaime Vacquer-Alicea, Shamiram Melhem, Harro Seelaar, John van Swieten, Marc Diamond, Lukasz Joachimiak
Amyloid deposition of the microtubule-associated protein tau is a unifying theme in a multitude of neurodegenerative diseases. Disease-associated missense mutations in tau are associated with frontotemporal dementia (FTD) and enhance tau aggregation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c1179a05ce563319b0ed05047ae812
https://doi.org/10.21203/rs.3.rs-1950269/v1
https://doi.org/10.21203/rs.3.rs-1950269/v1
Autor:
Rachel L. Doser, Dailu Chen, Judith A. Tello, David R. Andrew, Linda L. Restifo, William E. Conner, Mariah E. Moe, Jaswinder K. Ghuman
Publikováno v:
Journal of Neurogenetics. 35:1-22
Mutations in hundreds of genes cause neurodevelopmental disorders with abnormal motor behavior alongside cognitive deficits. Boys with fragile X syndrome (FXS), a leading monogenic cause of intelle...
Autor:
Hilda Mirbaha, Dailu Chen, Vishruth Mullapudi, Sandi Jo Terpack, Charles L. White, Lukasz A. Joachimiak, Marc I. Diamond
Tau aggregation into ordered assemblies causes myriad neurodegenerative tauopathies. We previously reported that tau monomer exists in either inert (Mi) or seed-competent (Ms) conformational ensembles, and that Ms encodes strains, which are biologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7f39d38e93b747168f9a8c71db2cd02
https://doi.org/10.1101/2022.01.03.474806
https://doi.org/10.1101/2022.01.03.474806
Autor:
Hilda Mirbaha, Dailu Chen, Vishruth Mullapudi, Sandi Jo Terpack, Charles L. White, Lukasz A. Joachimiak, Marc I. Diamond
Publikováno v:
Journal of Biological Chemistry. 298:102163
Tau aggregation into ordered assemblies causes neurodegenerative tauopathies. We previously reported that tau monomer exists in either inert (M