A cell-penetrating peptide derived from SARS-CoV-2 protein Orf9b allosterically inhibits MARK4 activity and mitigates tau toxicity

Autor: Toshiya Oba, Daiki Homma, Sophia Jobien M. Limlingan, Aoi Fukuchi, Akiko Asada, Taro Saito, Kanae Ando

Publikováno v: Neurobiology of Disease, Vol 188, Iss , Pp 106334- (2023)

Abnormal activation of microtubule affinity-regulating kinase 4 (MARK4) and its phosphorylation of the microtubule-associated protein tau are believed to play a role in the pathogenesis of Alzheimer's disease, and MARK4 inhibition can be a strategy t

Externí odkaz: https://doaj.org/article/666cf8a5f97343cc86ca130d2390aa1c

Rotational Behavior of N-(5-Substituted-pyrimidin-2-yl)anilines: Relayed Electronic Effect in Two N–Ar Bond Rotations

Autor: Daiki Homma, Shuhei Taketani, Takeshi Shirai, Elsa Caytan, Christian Roussel, José Elguero, Ibon Alkorta, Osamu Kitagawa

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Journal of Organic Chemistry
Journal of Organic Chemistry, 2022, 87 (12), pp.8118-8125. ⟨10.1021/acs.joc.2c00845⟩

N-Methyl-2-methoxymethylanilines 1 bearing vari- ous 5-substituted-pyrimidin-2-yl groups were prepared, and their rotational behaviors were explored in detail. It was revealed that the rotational barriers around two N−Ar bonds increase in proportio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2891238284597fa32fd050b5be3fd34b
http://hdl.handle.net/10261/272149