Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Daigoro Hirohama"'
Autor:
Shigeyoshi Oba, Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Wakako Kawarazaki, Kohei Ueda, Daigoro Hirohama, Fumiko Kawakami-Mori, Tatsuo Shimosawa, Takeshi Marumo, Toshiro Fujita
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Abstract Epigenetic modulation may underlie the progression of diabetic nephropathy (DN). Involvement of TGFB1 in mesangial fibrosis of DN led us to hypothesize that Tgfb1 DNA demethylation contributes to progression of DN. In primary mesangial cells
Externí odkaz:
https://doaj.org/article/25e25c0186854cdaaea68a964729952f
Autor:
Takeshi Marumo, Wakako Kawarazaki, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Daigoro Hirohama, Toshikazu Okaneya, Kazunari Yuki, Yoshihito Atsumi, Atsuhisa Sato, Eri Arai, Yae Kanai, Tatsuo Shimosawa, Toshiro Fujita
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020)
Introduction Renal tubular injury contributes to the decline in kidney function in patients with diabetes. Cell type-specific DNA methylation patterns have been used to calculate proportions of particular cell types. In this study, we developed a met
Externí odkaz:
https://doaj.org/article/108e46a7319944d8a35687fd997ea66e
Autor:
Koshu Okubo, Mako Kamiya, Yasuteru Urano, Hiroshi Nishi, Jan M. Herter, Tanya Mayadas, Daigoro Hirohama, Kazuo Suzuki, Hiroshi Kawakami, Mototsugu Tanaka, Miho Kurosawa, Shinji Kagaya, Keiichi Hishikawa, Masaomi Nangaku, Toshiro Fujita, Matsuhiko Hayashi, Junichi Hirahashi
Publikováno v:
EBioMedicine, Vol 10, Iss C, Pp 204-215 (2016)
Neutrophils are central players in the innate immune system. They generate neutrophil extracellular traps (NETs), which protect against invading pathogens but are also associated with the development of autoimmune and/or inflammatory diseases and thr
Externí odkaz:
https://doaj.org/article/e0ab3864351b42569f8d92f288f0f789
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 15, p 5358 (2020)
The kidney and the vasculature play crucial roles in regulating blood pressure. The ubiquitin proteasome system (UPS), a multienzyme process mediating covalent conjugation of the 76-amino acid polypeptide ubiquitin to a substrate protein followed by
Externí odkaz:
https://doaj.org/article/e1c0c2c5304b4affbd9bff76d4a28b43
Autor:
Daigoro Hirohama, Wakako Kawarazaki, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Takeshi Marumo, Shigeru Shibata, Toshiro Fujita
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 12, p 4433 (2020)
Renal inflammation is known to be involved in salt-induced renal damage, leading to end-stage renal disease. This study aims to evaluate the role of inflammation in anti-inflammatory and renoprotective effects of beraprost sodium (BPS), a prostagland
Externí odkaz:
https://doaj.org/article/06550c29178a4fdb997c09cb54a9a00d
Bilateral Spontaneous Perirenal Hemorrhage in an Acquired Cystic Kidney Disease Hemodialysis Patient
Autor:
Daigoro Hirohama, Hiroshi Miyakawa
Publikováno v:
Case Reports in Nephrology, Vol 2012 (2012)
Acquired cystic kidney disease (ACKD) is a well-known late stage complication of chronic kidney disease. Cysts tend to grow with time on dialysis and could lead to malignant transformation, and intra- or perirenal hemorrhage is a rare complication of
Externí odkaz:
https://doaj.org/article/70bd0a013ed140f2947cfb320dc2bc3d
Autor:
Minoru Yasukawa, Shigeyuki Arai, Michito Nagura, Ryo Kido, Shinichiro Asakawa, Daigoro Hirohama, Osamu Yamazaki, Yoshifuru Tamura, Michitaka Fujimaki, Sawako Kobayashi, Masakazu Mimaki, Hiroko Kodama, Shunya Uchida, Yoshihide Fujigaki, Shigeru Shibata
Publikováno v:
Kidney International Reports. 7:1565-1574
Impaired response to erythropoiesis-stimulating agents (ESAs) is associated with increased mortality in patients with end-stage kidney disease. However, the underlying mechanisms are not fully elucidated. Accumulating data reveal that selenium (Se),
Autor:
Daigoro Hirohama, Amin Abedini, Salina Moon, Aditya Surapaneni, Simon T. Dillon, Allison Vassalotti, Hongbo Liu, Tomohito Doke, Victor Martinez, Zaipul Md Dom, Anil Karihaloo, Matthew B. Palmer, Josef Coresh, Morgan E. Grams, Monika A. Niewczas, Katalin Susztak
Publikováno v:
Journal of the American Society of Nephrology.
Autor:
Kenichi Ishizawa, Osamu Yamazaki, Daigoro Hirohama, Yoshihide Fujigaki, Michito Nagura, Fumika Ochiai-Homma, Shinichiro Asakawa, Wataru Fujii, Shigeru Shibata, Masataka Murakawa, Tetsuo Nishikawa, Kohei Odajima, Shigeyuki Arai, Mika Kawagoe, Yoshihiro Tomomitsu, Yuya Tsurutani, Yoshifuru Tamura, Emiko Kuribayashi-Okuma
Publikováno v:
Hypertension Research
Pendrin is a Cl−/HCO3− exchanger selectively present in the intercalated cells of the kidney. Although experimental studies have demonstrated that pendrin regulates blood pressure downstream of the renin-angiotensin-aldosterone system, its role i
Autor:
Daigoro Hirohama, Shigeyoshi Oba, Mitsuhiro Nishimoto, Wataru Fujii, Shigeru Shibata, Wakako Kawarazaki, Toshiro Fujita, Nobuhiro Ayuzawa, Takeshi Marumo
Publikováno v:
Hypertension. 78:82-93
The progression of diabetic kidney disease (DKD), a leading cause of end-stage kidney disease, involves mineralocorticoid receptor (MR) activation. We previously identified crosstalk between the small guanosine triphosphatase (GTPase) RAS-related C3