Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Daigo, Nakazawa"'
Autor:
Yuka Nishibata, Suishin Arai, Mai Taniguchi, Issei Nakade, Hodaka Ogawa, Shota Kitano, Yumeka Hosoi, Ayano Shindo, Ryo Nishiyama, Sakiko Masuda, Daigo Nakazawa, Utano Tomaru, Takafumi Shimizu, William Sinko, Tadashi Nagakura, Yoh Terada, Akihiro Ishizu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Cathepsin C (CatC) is an enzyme which regulates the maturation of neutrophil serine proteases (NSPs) essential for neutrophil activation. Activated neutrophils are key players in the innate immune system, and are also implicated in the etiol
Externí odkaz:
https://doaj.org/article/6153810d7d844f19b1a34a9b91aced4d
Autor:
Issei Nakade, Yuto Tamura, Fuyu Hashimoto, Yuko Ariza, Shingo Hotta, Hirofumi Fujigaya, Suishin Arai, Mai Taniguchi, Hodaka Ogawa, Yuka Nishibata, Sakiko Masuda, Daigo Nakazawa, Utano Tomaru, Akihiro Ishizu
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-12 (2023)
Abstract Background Bruton’s tyrosine kinase (Btk) is an enzyme expressed in leukocytes other than T lymphocytes and plasma cells and involved in B-cell receptor- and Fcγ receptor (FcγR)-mediated signal transduction. Btk inhibitors potentially su
Externí odkaz:
https://doaj.org/article/060a526975d94c7b99f7ab3eb6855475
Autor:
Daigo Nakazawa, Yohei Takeda, Masatoshi Kanda, Utano Tomaru, Haruko Ogawa, Takashi Kudo, Satoka Shiratori-Aso, Kanako Watanabe-Kusunoki, Yusho Ueda, Atsuko Miyoshi, Fumihiko Hattanda, Saori Nishio, Ryo Uozumi, Akihiro Ishizu, Tatsuya Atsumi
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Acute kidney injury (AKI) is a common and severe complication of the coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly affects the glomerular and tubular epithelial cells to induce AKI
Externí odkaz:
https://doaj.org/article/0da0d3f5e2554fd6b2872a774f9c79f3
Autor:
Satoka Shiratori-Aso, Daigo Nakazawa
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a serious autoimmune disease that is characterized by vascular necrosis. The pathogenesis of AAV includes ANCA-mediated neutrophil activation, subsequent release of inflam
Externí odkaz:
https://doaj.org/article/b22c832b920f487eba905a59ee94f886
Autor:
Kuniyuki Aso, Michihito Kono, Masatoshi Kanda, Yuki Kudo, Kodai Sakiyama, Ryo Hisada, Kohei Karino, Yusho Ueda, Daigo Nakazawa, Yuichiro Fujieda, Masaru Kato, Olga Amengual, Tatsuya Atsumi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Dysregulation of T cell homeostasis is known to contribute to the immunopathology of autoimmune diseases. Here the authors show that itaconate impacts autoimmune pathology by altering T cells via modulation of metabolic and epigenetic programs.
Externí odkaz:
https://doaj.org/article/68f268483d2847d9a8c8f89d4540a446
Autor:
Daigo Nakazawa, Yohei Takeda, Masatoshi Kanda, Utano Tomaru, Haruko Ogawa, Takashi Kudo, Satoka Shiratori‐Aso, Kanako Watanabe‐Kusunoki, Yusho Ueda, Atsuko Miyoshi, Fumihiko Hattanda, Saori Nishio, Ryo Uozumi, Akihiro Ishizu, Tatsuya Atsumi
Publikováno v:
FEBS Open Bio, Vol 13, Iss 1, Pp 60-71 (2023)
Severe coronavirus disease 2019 (COVID‐19) is characterized by acute respiratory distress syndrome and multiple organ dysfunction, in which the host immune response plays a pivotal role. Excessive neutrophil activation and subsequent superfluity of
Externí odkaz:
https://doaj.org/article/96abd4d6ac8e4c968aabafa555541ac1
Autor:
Miku Yoshinari, Yuka Nishibata, Sakiko Masuda, Daigo Nakazawa, Utano Tomaru, Yoshihiro Arimura, Koichi Amano, Yukio Yuzawa, Ken-Ei Sada, Tatsuya Atsumi, Hiroaki Dobashi, Hitoshi Hasegawa, Masayoshi Harigai, Seiichi Matsuo, Hirofumi Makino, Akihiro Ishizu
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-9 (2022)
Abstract Background Neutrophil extracellular traps (NETs) are critically involved in microscopic polyangiitis (MPA) pathogenesis, and some patients with MPA possess anti-NET antibody (ANETA). Anti-myosin light chain 6 (MYL6) antibody is an ANETA that
Externí odkaz:
https://doaj.org/article/d4340aa3fa924e148ce2b22195564db0
Autor:
Utano Tomaru, Akihiro Ishizu, Tomohiro Shimizu, Norimasa Iwasaki, Hodaka Ogawa, Shunichi Yokota, Yumeka Hosoi, Ayano Shindo, Naho Ogawa, Ryodai Yamamura, Issei Nakade, Suishin Arai, Mai Taniguchi, Yuka Nishibata, Sakiko Masuda, Daigo Nakazawa
Publikováno v:
Lupus Science and Medicine, Vol 10, Iss 2 (2023)
Objectives Methylprednisolone (mPSL) pulse therapy is an essential option for patients with active systemic lupus erythematosus, but there is a risk of adverse events related to microcirculation disorders, including idiopathic osteonecrosis of the fe
Externí odkaz:
https://doaj.org/article/2333c6ddd6e6495f84b15dbdcb64e1b7
Autor:
Satoka Shiratori-Aso, Daigo Nakazawa, Takashi Kudo, Masatoshi Kanda, Yusho Ueda, Kanako Watanabe-Kusunoki, Saori Nishio, Sari Iwasaki, Takahiro Tsuji, Sakiko Masuda, Utano Tomaru, Akihiro Ishizu, Tatsuya Atsumi
Publikováno v:
JCI Insight, Vol 8, Iss 15 (2023)
Neutrophil extracellular trap (NET) formation contributes to immune defense and is a distinct form of cell death. Excessive NET formation is found in patients with anti–neutrophil cytoplasmic antibody–associated (ANCA-associated) vasculitis (AAV)
Externí odkaz:
https://doaj.org/article/1c7f2a7aa3a5451a8954125e330d9e11
Autor:
Satoka Shiratori-Aso, Daigo Nakazawa, Saori Nishio, Yusho Ueda, Mina Eguchi, Ai Yokoyama, Junpei Yoshikawa, Takashi Kudo, Kanako Watanabe-Kusunoki, Sayo Takeda-Otera, Junya Yamamoto, Naoko Matsuoka, Nobuharu Kaneshima, Fumihiko Hattanda, Sari Iwasaki, Takahiro Tsuji, Yuichiro Fukasawa, Tatsuya Atsumi
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
BackgroundAutoimmune tubulointerstitial nephritis (TIN) is characterized by immune-mediated tubular injury and requires immunosuppressive therapy. However, diagnosing TIN and assessing therapeutic response are challenging for clinicians due to the la
Externí odkaz:
https://doaj.org/article/c1a3730d10b0480684fb902615e0ad18