Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Daichao Wu"'
Autor:
Zhouchi Yao, Yayun Zeng, Cheng Liu, Huimin Jin, Hong Wang, Yue Zhang, Chengming Ding, Guodong Chen, Daichao Wu
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-30 (2024)
Abstract Vigorous CD8+ T cells play a crucial role in recognizing tumor cells and combating solid tumors. How T cells efficiently recognize and target tumor antigens, and how they maintain the activity in the “rejection” of solid tumor microenvir
Externí odkaz:
https://doaj.org/article/c159f7deadc24d5cbcbfdeed7b8a2bc0
Autor:
Cecily Choy, Joseph Chen, Jiangyuan Li, D. Travis Gallagher, Jian Lu, Daichao Wu, Ainslee Zou, Humza Hemani, Beverly A. Baptiste, Emily Wichmann, Qian Yang, Jeffrey Ciffelo, Rui Yin, Julia McKelvy, Denise Melvin, Tonya Wallace, Christopher Dunn, Cuong Nguyen, Chee W. Chia, Jinshui Fan, Jeannie Ruffolo, Linda Zukley, Guixin Shi, Tomokazu Amano, Yang An, Osorio Meirelles, Wells W. Wu, Chao-Kai Chou, Rong-Fong Shen, Richard A. Willis, Minoru S. H. Ko, Yu-Tsueng Liu, Supriyo De, Brian G. Pierce, Luigi Ferrucci, Josephine Egan, Roy Mariuzza, Nan-Ping Weng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The resolution of SARS-CoV-2 replication hinges on cell-mediated immunity, wherein CD8+ T cells play a vital role. Nonetheless, the characterization of the specificity and TCR composition of CD8+ T cells targeting non-spike protein of SARS-C
Externí odkaz:
https://doaj.org/article/963224e732b44fa8b3d0805dabc27063
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Adoptive cell therapy (ACT) with tumor-specific T cells has been shown to mediate durable cancer regression. Tumor-specific T cells are also the basis of other therapies, notably cancer vaccines. The main target of tumor-specific T cells are neoantig
Externí odkaz:
https://doaj.org/article/77ed598acda54e73a773868631ad76f2
Autor:
Daichao Wu, Alexander Kolesnikov, Rui Yin, Johnathan D. Guest, Ragul Gowthaman, Anton Shmelev, Yana Serdyuk, Dmitry V. Dianov, Grigory A. Efimov, Brian G. Pierce, Roy A. Mariuzza
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Structural immunology is critical in understanding the interplay between the immune response and the infective agent but such studies in T cells and SARS-CoV-2 lag behind those of antibodies and B-cell receptors. Here the authors assess recognition o
Externí odkaz:
https://doaj.org/article/88ff2336853b4fc5ae388f4cc35fedd1
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-14 (2021)
Abstract Fibroblast growth factor receptors (FGFRs) play key roles in promoting the proliferation, differentiation, and migration of cancer cell. Inactivation of FGFRs by tyrosine kinase inhibitors (TKI) has achieved great success in tumor-targeted t
Externí odkaz:
https://doaj.org/article/62a90093d1be4b95a4e4cd77f06ea8ad
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Developing broadly applicable neoantigen-directed adoptive cell therapies (ACTs) is challenging because each cancer patient has an unique neoantigen repertoire. Here, the authors present the crystal structures of tumor-specific T cell receptors (TCRs
Externí odkaz:
https://doaj.org/article/539421cdbf2649ba84e049f00249ee1a
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Microliposome maintenance (MCM) 2, MCM3, MCM4, MCM5, MCM6, and MCM7 are DNA replication regulators and are involved in the progression of multiple cancer types, but their role in ovarian cancer is still unclear. The purpose of this study is to clarif
Externí odkaz:
https://doaj.org/article/aec91528b19c44bf9ca9c41b65fac82c
Autor:
Daichao Wu, Ming Guo, Michael A Philips, Lingzhi Qu, Longying Jiang, Jun Li, Xiaojuan Chen, Zhuchu Chen, Lin Chen, Yongheng Chen
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162491 (2016)
Aberrant FGFR4 signaling has been documented abundantly in various human cancers. The majority of FGFR inhibitors display significantly reduced potency toward FGFR4 compared to FGFR1-3. However, LY2874455 has similar inhibition potency for FGFR1-4 wi
Externí odkaz:
https://doaj.org/article/92093abd062b45c1b8b07dd17a920c1b
Publikováno v:
Journal of Biological Chemistry. 299:103035
Publikováno v:
Reviews in the Neurosciences. 32:79-91
Smoking is the leading preventable cause of death worldwide and tobacco addiction has become a serious public health problem. Nicotine is the main addictive component of tobacco, and the majority of people that smoke regularly develop nicotine depend