Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Dai-chang Yang"'
Publikováno v:
Drug Metabolism and Disposition. 30:1013-1021
Valdecoxib is a potent and specific inhibitor of cyclooxygenase-2, which is used for the treatment of rheumatoid arthritis, osteoarthritis, and the dysmenorrhea pain. Eight male human subjects each received a single 50-mg oral dose of [(14)C]valdecox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c31e8f1054e55d3bfb8751fc52f51f
https://doi.org/10.1124/dmd.30.9.1013
https://doi.org/10.1124/dmd.30.9.1013
Autor:
Yue-Fen Wang, Dai-chang Yang, Ji Y. Zhang, Jinhua Yuan, Susan K. Paulson, Caroline Dudkowski, Ming Chang, Alan P. Breau
Publikováno v:
Journal of Mass Spectrometry. 35:1259-1270
The metabolism of the anti-inflammatory drug Celecoxib in rabbits was characterized using liquid chromatography (LC)/tandem mass spectrometry (MS/MS) with precursor ion and constant neutral loss scans followed by product ion scans. After separation b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a492812cc89a017f3fcc4e564aa218ee
https://doi.org/10.1002/1096-9888(200011)35:11<1259::aid-jms57>3.0.co
https://doi.org/10.1002/1096-9888(200011)35:11<1259::aid-jms57>3.0.co
Autor:
Dai-Chang Yang, G. W. Gullikson, Daniel L. Flynn, Daniel P. Becker, Clara I. Villamil, Roger Nosal, Chafiq Moummi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2149-2154
A series of meso-amino(methyl)azanoradamantane benzamides has been prepared and evaluated for 5-HT4 agonism activity in the rat tunica muscularis mucosae (TMM) assay. Compound 8i is the most potent 5-HT4 agonist in the series, with an EC50 of 217 nM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23b42abbb49f0bda55dc9bbc18197fba
https://doi.org/10.1016/s0960-894x(97)00408-3
https://doi.org/10.1016/s0960-894x(97)00408-3
Autor:
Dai-Chang Yang, Roger Nosal, Daniel L. Flynn, Clara I. Villamil, Chafiq Moummi, G. W. Gullikson, Daniel P. Becker
Publikováno v:
ChemInform. 29
A series of meso-amino(methyl)azanoradamantane benzamides has been prepared and evaluated for 5-HT4 agonism activity in the rat tunica muscularis mucosae (TMM) assay. Compound 8i is the most potent 5-HT4 agonist in the series, with an EC50 of 217 nM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60106a1804efbed52b309ff774b120a9
https://doi.org/10.1002/chin.199801172
https://doi.org/10.1002/chin.199801172
Autor:
Chafiq Moummi, Dai-Chang Yang, Daniel L. Flynn, Roger Nosal, Daniel P. Becker, G. W. Gullikson, Dale P. Spangler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1613-1618
New aza(nor)adamantanes 1A , 1B , and 1C are described which exhibit properties of both 5-HT4 agonism and 5-HT3 antagonism. In particular, compound 1C [SC-52491], an azanoradamantane, exhibits an EC50 of 51 nM in a functional model of 5-HT4 agonism a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee8ca2120c6861af925b4314701bf4e8
https://doi.org/10.1016/s0960-894x(00)80441-2
https://doi.org/10.1016/s0960-894x(00)80441-2
Autor:
Daniel L. Flynn, Chafiq Moummi, Dai-Chang Yang, Daniel P. Becker, G. W. Gullikson, Clara I. Villamil
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1251-1256
A new series of cholecystokinin (CCK) antagonists are described which utilizes a new 1,3,4-trisubstituted pyrrolidinone as a scaffold for appending specific amino acid R group mimics (Figure 1). Compound 1A and 1E (SC-50998) exhibit potent nanomolar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf05097a14e72e4db52a818dfe925918
https://doi.org/10.1016/s0960-894x(00)80224-3
https://doi.org/10.1016/s0960-894x(00)80224-3
Publikováno v:
European Journal of Pharmacology. 216:47-52
Changes in mechanical events and intracellular levels of cAMP induced by the activation of the 5-HT4 receptor were investigated in the rat esophagus tunica muscularis mucosae preparation. Serotonin (5-HT) and 5 methoxytryptamine (5-MOT; 5-HT4 agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3acd529624afe4f27cca7570f8bc63
https://doi.org/10.1016/0014-2999(92)90207-k
https://doi.org/10.1016/0014-2999(92)90207-k
Autor:
Maida A. Virina, Dai-Chang Yang, Bela Goldstin, Alan E. Moormann, Daniel L. Flynn, R F Loeffler, G. W. Gullikson
Publikováno v:
Drug Development Research. 26:405-417
Zacopride is an antiemetic agent whose (S) and (R) stereoisomers demonstrate differential pharmacology at 5-HT3 receptors, emphasizing the importance of pharmacologic profiling of each enantiomer of a racemic drug mixture. Characterization of the gas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a063b29be2951d8486f7347ac9650e2c
https://doi.org/10.1002/ddr.430260404
https://doi.org/10.1002/ddr.430260404
Publikováno v:
Journal of pharmacokinetics and biopharmaceutics. 23(1)
Certain compounds such as SC-52151 have extensive nonspecific adsorption to the ultrafiltration devices or to dialysis membranes and therefore can not be measured by the conventional ultrafiltration or equilibrium dialysis methods. A new method based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e4a2dabb1feeff5948b061aafb2592
https://pubmed.ncbi.nlm.nih.gov/8576843
https://pubmed.ncbi.nlm.nih.gov/8576843
Autor:
Mary Alice Stetler-Stevenson, Linda McCartney, Darryl R. Peterson, George Flouret, Dai Chang Yang, Andrew Lipkowski
Publikováno v:
Journal of Medicinal Chemistry. 24:688-692
Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba548e88854127ff1bf9834413a20b6
https://doi.org/10.1021/jm00138a009
https://doi.org/10.1021/jm00138a009