Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Dai-Shi Su"'
Autor:
Zhi Liu, Dai-Shi Su, Sanjay Kumar, Kimberly Roland, Lin Xiaojuan, Rick Keenan, Qin Donghui, Jeff Fergusson, Linlin Liu, John G. Emery, Sylvie Laquerre, Mui Cheung, Allen Oliff, Chengde Wu, Yan Pan, Zhiliu Zhang, Yan Chen
Publikováno v:
ACS Med Chem Lett
[Image: see text] We report herein the discovery of quinazolindiones as potent and selective tankyrase inhibitors. Elucidation of the structure–activity relationship of the lead compound 1g led to truncated analogues that have good potency in cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f046a4209b2aae583bca1a2007ee761
https://doi.org/10.1021/acsmedchemlett.1c00160
https://doi.org/10.1021/acsmedchemlett.1c00160
Autor:
Ryan G. Kruger, Junya Qu, Dai-Shi Su, Helai P. Mohammad, Melissa B. Pappalardi, Patricia A. Elkins, Alan P. Graves, Dirk A. Heerding, William G. Bonnette, Joelle Lorraine Burgess, Juan I. Luengo, Jenny Zeng, Beth Anne Knapp-Reed, Mark J. Schulz, Alexander Joseph Reif, Jeffrey D. Carson, Raman P. Nagarajan, Caretha L. Creasy, Chuck W Blackledge, Kristen Wong, Melissa Stern, Charles F. McHugh, Hongyi Yu, Liping Wang
Publikováno v:
ACS Med Chem Lett
[Image: see text] We report herein the discovery of isoxazole amides as potent and selective SET and MYND Domain-Containing Protein 3 (SMYD3) inhibitors. Elucidation of the structure–activity relationship of the high-throughput screening (HTS) lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83a077b5e8d3e9547f467b0db76acd2
https://pubmed.ncbi.nlm.nih.gov/32071679
https://pubmed.ncbi.nlm.nih.gov/32071679
Publikováno v:
Medicinal Chemistry Reviews ISBN: 9780996293235
Medicinal Chemistry Reviews
Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f220110ead3c47fef6ab4fc5bff296a5
https://doi.org/10.29200/acsmedchemrev-v51.ch12
https://doi.org/10.29200/acsmedchemrev-v51.ch12
Autor:
Carolyn L. Ladd, Dai‐Shi Su, Kathlyn A. Parker, Alexei V. Demchenko, Phillip M. Pelphrey, Dennis L. Wright
Publikováno v:
e-EROS Encyclopedia of Reagents for Organic Synthesis
[20667-12-3] Ag2O (MW 231.74) InChI = 1/2Ag.O/rAg2O/c1-3-2 InChIKey = KHJDQHIZCZTCAE-FQKFHCGGAZ (oxidizing reagent for conversion of hydroquinones to quinones,1 alkylphenols to quinone methides,5 and aldehydes to acids;7 oxidative coupling reactions;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f8c441fb71244ac35d182fb0ff6a800
https://doi.org/10.1002/047084289x.rs024.pub4
https://doi.org/10.1002/047084289x.rs024.pub4
Autor:
Ryan G. Kruger, Roland S. Annan, Patricia A. Elkins, Tony W. Dean, Patrick McDevitt, Helai P. Mohammad, Francesca Zappacosta, Alan P. Graves, William G. Bonnette, Dai-Shi Su, Glenn S. Van Aller, Christopher L. Carpenter
Publikováno v:
Structure (London, England : 1993). 24(5)
SMYD3 is a lysine methyltransferase overexpressed in colorectal, breast, prostate, and hepatocellular tumors, and has been implicated as an oncogene in human malignancies. Methylation of MEKK2 by SMYD3 is important for regulation of the MEK/ERK pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c014e8bdf029a94d408ffb0ea803a65
https://pubmed.ncbi.nlm.nih.gov/27066749
https://pubmed.ncbi.nlm.nih.gov/27066749
Autor:
Sharon Sweitzer, Jeff Ralph, Maurice P. Deyoung, Angela Smallwood, William G. Bonnette, Karen A. Evans, Anthony E. Choudhry, Dai-Shi Su, Hongwei Qi, Kelly Federowicz, Dirk A. Heerding, Rachel D. Totoritis, Leanna E. Shuster, Nino Campobasso, Nestor O. Concha, Stephanie Chen, Jingsong Yang, Guofeng Zhang, Carolyn A. Buser
Publikováno v:
Molecular pharmacology. 88(6)
Activation of the inositol-requiring enzyme-1 alpha (IRE1α) protein caused by endoplasmic reticulum stress results in the homodimerization of the N-terminal endoplasmic reticulum luminal domains, autophosphorylation of the cytoplasmic kinase domains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc288f3e8032263ef0f0c904a86eb52
https://pubmed.ncbi.nlm.nih.gov/26438213
https://pubmed.ncbi.nlm.nih.gov/26438213
Autor:
J. Fred Hess, Kathryn L. Murphy, Mark G. Bock, Rick W. Ransom, Dai-Shi Su, Douglas J. Pettibone, Tsing-Bau Chen, R. S. L. Chang, Sookhee Ha, Pat J. Hey
Publikováno v:
Biochemistry. 45:14355-14361
We report the critical residues for the interaction of the kinins with human bradykinin receptor 1 (B1) using site-directed mutagenesis in conjunction with molecular modeling of the binding modes of the kinins in the homology model of the B1 receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc55ace01757df410c1bda88fec544d
https://doi.org/10.1021/bi060673f
https://doi.org/10.1021/bi060673f
Autor:
Kathlyn A. Parker, Dai‐Shi Su
Publikováno v:
Journal of Carbohydrate Chemistry. 24:187-197
A three‐step sequence affects the regio‐ and stereospecific elaboration of an aryl C‐aminoglycoside from a simple aminoglycal and a quinone. Direct lithiation of the glycal followed by addition of the quinone, reduction of the quinol adduct, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa02a82c8bea4a9a73d53e38629d3721
https://doi.org/10.1081/car-200059957
https://doi.org/10.1081/car-200059957
Autor:
Dai‐Shi Su, Kathlyn A. Parker
Publikováno v:
Journal of Carbohydrate Chemistry. 24:199-208
A two‐step sequence converts protected glycal‐substituted quinols to aryl bis C‐glycals in which one or both of the substituents is an aminoglycal. First, a lithiated glycal undergoes 1,2‐addition to the carbonyl group of a protected glycal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::158bbdf258a760bd03f61d5ee4590a7f
https://doi.org/10.1081/car-200059936
https://doi.org/10.1081/car-200059936
Autor:
J. Fred Hess, Michael A. Wallace, Rick W. Ransom, Douglas J. Pettibone, C. Meacham Harrell, Kathy L. Murphy, Matthew M. Zrada, Roger M. Freidinger, M. Kristine Markowitz, Bang-Lin Wan, Dai-Shi Su, Mark G. Bock, Dennis C. Dean, R. S. L. Chang, S. S. O'malley, Conrad E. Raab
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:6045-6048
We have developed an efficient and selective radioligand, the [35S]-radiolabeled dihydroquinoxalinone derivative, 4, for an ex vivo receptor occupancy assay in transgenic rats over-expressing the human bradykinin B1 receptor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd26b8e760658cf74db72a04fe61f73b
https://doi.org/10.1016/j.bmcl.2004.09.074
https://doi.org/10.1016/j.bmcl.2004.09.074