Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Dai Nozawa"'
Autor:
Ayaka Kaku-Fukumoto, Noriko Hino, Hirohiko Hikichi, Dai Nozawa, Jun-ichi Karasawa, Toshio Nakamura, Emi Tatsuda, Shigeyuki Chaki, Yasumitsu Tomishima, Toshiyuki Marumo, Toshiharu Shimazaki, Makiko Kotani, Hiroko Komiyama
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 375:276-285
Histamine H3 receptor antagonists/inverse agonists are known to enhance the activity of histaminergic neurons in the brain, thereby promoting arousal and cognition. Here, we report the in vitro and in vivo pharmacological profiles for a newly synthes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cf1b46a58c5f29e719fa092f8a420ec
https://doi.org/10.1124/jpet.120.000185
https://doi.org/10.1124/jpet.120.000185
Autor:
Noriko, Hino, Toshiyuki, Marumo, Makiko, Kotani, Toshiharu, Shimazaki, Ayaka, Kaku-Fukumoto, Hirohiko, Hikichi, Jun-Ichi, Karasawa, Yasumitsu, Tomishima, Hiroko, Komiyama, Emi, Tatsuda, Dai, Nozawa, Toshio, Nakamura, Shigeyuki, Chaki
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 375(2)
Histamine H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4bb83aca81af8a17a5879f4ee7f1340
https://pubmed.ncbi.nlm.nih.gov/32862143
https://pubmed.ncbi.nlm.nih.gov/32862143
Autor:
Tetsuaki Hiyoshi, Dai Nozawa, Sora Kirinuki, Daiji Kambe, Yuichi Tokumaru, Ryo Suzuki, Mari Ohmichi, Hiroshi Kawamoto, Yunoshin Tamura, Futamura Aya, Takeshi Aoki, Noriko Hino
Publikováno v:
Bioorganicmedicinal chemistry. 28(13)
Here, we present the design, synthesis, and SAR of dual orexin 1 and 2 receptor antagonists, which were optimized by balancing the antagonistic activity for orexin receptors and lipophilicity. Based on the prototype compound 1, ring construction and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80a5d80c33d03264b839ba902d39132
https://pubmed.ncbi.nlm.nih.gov/32482533
https://pubmed.ncbi.nlm.nih.gov/32482533
Autor:
Futamura Aya, Dai Nozawa, Seiken Tokura, Yuichi Tokumaru, Yuko Araki, Norikazu Ohtake, Yunoshin Tamura, Hiroshi Kawamoto, Sora Kakihara, Takeshi Aoki
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:5203-5215
The design, synthesis, and structure activity relationships of the novel class of pyrazolylethylbenzamide orexin receptor 1-selective antagonists are described. Further derivatization of the prototype dual orexin receptor 1/2 antagonist lead (1) by i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f07cf6376c75baf1059cdd28966fe0
https://doi.org/10.1016/j.bmc.2017.07.051
https://doi.org/10.1016/j.bmc.2017.07.051
Publikováno v:
Expert Opinion on Therapeutic Patents. 18:403-427
Background: Melanocortins, which are derived from proopiomelanocortin, have been implicated in a variety of physiological processes. To date, five subtypes of melanocortin receptors have been identified, all of which are G-protein–coupled receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0457f28699c282ce2f1f0531baeddf0c
https://doi.org/10.1517/13543776.18.4.403
https://doi.org/10.1517/13543776.18.4.403
Autor:
Dai Nozawa, Shigeru Okuyama, Shigeyuki Chaki, Taketoshi Okubo, Atsuro Nakazato, Takaaki Ishii
Publikováno v:
Chemical and Pharmaceutical Bulletin. 55:1044-1050
While examining antagonists of the melanocortin-4 receptor (MC4 receptor), we found that compound 12b, containing a diphenylmethyl moiety, had a relatively high affinity for the MC4 receptor. When diphenylmethyl analogues were further examined, compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73541f624af909bf057b5251fe701e4e
https://doi.org/10.1248/cpb.55.1044
https://doi.org/10.1248/cpb.55.1044
Publikováno v:
Chemical and Pharmaceutical Bulletin. 55:1232-1239
In the present study, conducted to explore potent and small molecular melanocortin-4 (MC4) receptor ligands, we found that tripeptide 3a, containing a D-Phe-Arg-2-Nal (Nal; naphthylalanine) sequence, exhibited a moderate affinity for the MC4 receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7f0cf69ce56cc123240a05a19b9a20
https://doi.org/10.1248/cpb.55.1232
https://doi.org/10.1248/cpb.55.1232
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :657-661
Both the enantiomers of stellettadine A (1), a bisguanidinium alkaloid isolated from a marine sponge Stelletta sp., are synthesized by starting from (S)- and (R)-citronellal (2). The absolute configuration of naturally occurring 1 is established as R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43dd06a0e917a53910ea088f7cdab180
https://doi.org/10.1039/b100206f
https://doi.org/10.1039/b100206f
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :2467-2477
Sulfobacin A (1), B (2), and flavocristamide A (3), new sulfonolipids isolated from Chryseobacterium sp. were synthesized stereoselectively by starting from L-cysteine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::363f6c8b68cc877099ed0f2f0b8a23de
https://doi.org/10.1039/a904258j
https://doi.org/10.1039/a904258j
Publikováno v:
Tetrahedron Letters. 39:6931-6934
Sulfobacin A (1) and B (2), new sulfonolipids isolated from Chryseobacterium sp. as von Willebrand factor antagonists, were synthesized stereoselectively by starting from l-cysteine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d2b61e0fd4dedaf9b36707904b78e4f
https://doi.org/10.1016/s0040-4039(98)01456-7
https://doi.org/10.1016/s0040-4039(98)01456-7