Zobrazeno 1 - 10 of 235 pro vyhledávání: '"Dai NAKAE"'
1
Akademický článek
Two-year intermittent exposure of a multiwalled carbon nanotube by intratracheal instillation induces lung tumors and pleural mesotheliomas in F344 rats
Autor: Motoki Hojo, Ai Maeno, Yoshimitsu Sakamoto, Aya Ohnuki, Yukie Tada, Yukio Yamamoto, Kiyomi Ikushima, Ryota Inaba, Jin Suzuki, Yuhji Taquahashi, Satoshi Yokota, Norihiro Kobayashi, Makoto Ohnishi, Yuko Goto, Takamasa Numano, Hiroyuki Tsuda, David B. Alexander, Jun Kanno, Akihiko Hirose, Akiko Inomata, Dai Nakae
Publikováno v: Particle and Fibre Toxicology, Vol 19, Iss 1, Pp 1-23 (2022)
Abstract Background A mounting number of studies have been documenting the carcinogenic potential of multiwalled carbon nanotubes (MWCNTs); however, only a few studies have evaluated the pulmonary carcinogenicity of MWCNTs in vivo. A 2-year inhalatio
Externí odkaz: https://doaj.org/article/206a844169344007b85b1a278d8bca76
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2
Akademický článek
Nonobese mice with nonalcoholic steatohepatitis fed on a choline‐deficient, l‐amino acid‐defined, high‐fat diet exhibit alterations in signaling pathways
Autor: Noriko Suzuki‐Kemuriyama, Akari Abe, Sae Nakane, Kinuko Uno, Shuji Ogawa, Atsushi Watanabe, Ryuhei Sano, Megumi Yuki, Katsuhiro Miyajima, Dai Nakae
Publikováno v: FEBS Open Bio, Vol 11, Iss 11, Pp 2950-2965 (2021)
Nonalcoholic steatohepatitis (NASH) is often associated with obesity, but some patients develop NASH without obesity. The physiological processes by which nonobese patients develop NASH and cirrhosis have not yet been determined. Here, we analyzed th
Externí odkaz: https://doaj.org/article/1f1412a381574fb1a0fe5dffddcb28a0
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3
Akademický článek
Time-Course of Transcriptomic Change in the Lungs of F344 Rats Repeatedly Exposed to a Multiwalled Carbon Nanotube in a 2-Year Test
Autor: Motoki Hojo, Ai Maeno, Yoshimitsu Sakamoto, Yukio Yamamoto, Yuhji Taquahashi, Akihiko Hirose, Jin Suzuki, Akiko Inomata, Dai Nakae
Publikováno v: Nanomaterials, Vol 13, Iss 14, p 2105 (2023)
Despite intensive toxicological studies of carbon nanotubes (CNTs) over the last two decades, only a few studies have demonstrated their pulmonary carcinogenicities in chronic animal experiments, and the underlying molecular mechanisms are still uncl
Externí odkaz: https://doaj.org/article/bdc9128d09514a6991ac08a695836c12
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4
Akademický článek
A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet
Autor: Noriko Suzuki-Kemuriyama, Akari Abe, Kiniko Uno, Shuji Ogawa, Atsushi Watanabe, Ryuhei Sano, Megumi Yuki, Katsuhiro Miyajima, Dai Nakae
Publikováno v: Lipids in Health and Disease, Vol 19, Iss 1, Pp 1-16 (2020)
Abstract Background Nonalcoholic steatohepatitis (NASH) is a form of liver disease characterized by steatosis, necroinflammation, and fibrosis, resulting in cirrhosis and cancer. Efforts have focused on reducing the intake of trans fatty acids (TFAs)
Externí odkaz: https://doaj.org/article/6f3573c001754a81b616cac0ff325a12
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6
Akademický článek
Comparison of fetal toxicity of various multi-wall carbon nanotubes in mice
Autor: Tomoko Fujitani, Akiko Inomata, Akio Ogata, Yoshimitsu Sakamoto, Akihiko Hirose, Tetsuji Nishimura, Reiko Ikeda, Dai Nakae
Publikováno v: Toxicology Reports, Vol 2, Iss C, Pp 1404-1408 (2015)
The fetal toxicities of multi-wall carbon nanotubes (MWCNTs) with various sizes were compared in CD1(ICR) mice. MWCNTs were suspended in 2% sodium carboxymethyl cellulose solution in phosphate-buffered saline. On day 9 of gestation, dams were adminis
Externí odkaz: https://doaj.org/article/78fb8895a39e4c8bbd87b2728728acb6
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7
Akademický článek
Magnetite Nanoparticles Induce Genotoxicity in the Lungs of Mice via Inflammatory Response
Autor: Yukari Totsuka, Kousuke Ishino, Tatsuya Kato, Sumio Goto, Yukie Tada, Dai Nakae, Masatoshi Watanabe, Keiji Wakabayashi
Publikováno v: Nanomaterials, Vol 4, Iss 1, Pp 175-188 (2014)
Nanomaterials are useful for their characteristic properties and are commonly used in various fields. Nanosized-magnetite (MGT) is widely utilized in medicinal and industrial fields, whereas their toxicological properties are not well documented. A s
Externí odkaz: https://doaj.org/article/3b9e75a2f16e4d07bcf73eb8abdc4595
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8
Akademický článek
Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice.
Autor: Noriko Suzuki-Kemuriyama, Takashi Matsuzaka, Motoko Kuba, Hiroshi Ohno, Song-Iee Han, Yoshinori Takeuchi, Masaaki Isaka, Kazuto Kobayashi, Hitoshi Iwasaki, Shigeru Yatoh, Hiroaki Suzuki, Katsuhiro Miyajima, Dai Nakae, Naoya Yahagi, Yoshimi Nakagawa, Hirohito Sone, Nobuhiro Yamada, Hitoshi Shimano
Publikováno v: PLoS ONE, Vol 11, Iss 6, p e0157580 (2016)
Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, can progress to steatohepatitis (NASH) and advanced liver damage, such as that from liver cirrhosis and cancer. Recent studies have shown the benefits of cons
Externí odkaz: https://doaj.org/article/ba72cf7df6544c9194ad881ba3772ffe
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