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Akademický článek

Identification of immune-associated biomarker for predicting lung adenocarcinoma: bioinformatics analysis and experiment verification of PTK6

Autor: Ren-Hui Xiong, Shuo-Qi Yang, Ji-Wei Li, Xun-kai Shen, Lu-Ming Jin, Chao-Yang Chen, Yu-Ting Yue, Zhi-Chen Yu, Qing-Yu Sun, Wen Jiang, Ming-Zheng Jiang, Xiao-Yan Wang, Shi-Xu Song, Dai Cao, Hong-li Ye, Li-Ran Zhao, Li-Peng Huang, Liang Bu

Publikováno v: Discover Oncology, Vol 15, Iss 1, Pp 1-21 (2024)

Abstract Background Abnormal expression of protein tyrosine kinase 6 (PTK6) has been proven to be involved in the development of gynecological tumors. However, its immune-related carcinogenic mechanism in other tumors remains unclear. Objective The a

Externí odkaz: https://doaj.org/article/ec100f6beb184953a14676866b008603

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Akademický článek

Boswellianols A–I, Structurally Diverse Diterpenoids from the Oleo-Gum Resin of Boswellia carterii and Their TGF-β Inhibition Activity

Autor: Zhi-Rong Lin, Meng-Yu Bao, Hao-Ming Xiong, Dai Cao, Li-Ping Bai, Wei Zhang, Cheng-Yu Chen, Zhi-Hong Jiang, Guo-Yuan Zhu

Publikováno v: Plants, Vol 13, Iss 8, p 1074 (2024)

Olibanum, a golden oleo-gum resin from species in the Boswellia genus (Burseraceae family), is a famous traditional herbal medicine widely used around the world. Previous phytochemical studies mainly focused on the non-polar fractions of olibanum. In

Externí odkaz: https://doaj.org/article/f8e12ee924bf499ebd75c07cc4d6fd60

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Akademický článek

Artesunate promoted anti-tumor immunity and overcame EGFR-TKI resistance in non-small-cell lung cancer by enhancing oncogenic TAZ degradation

Autor: Dai Cao, Die Chen, Jiang-Nan Xia, Wen-Yan Wang, Guo-Yuan Zhu, Li-Wen Chen, Chuantao Zhang, Bo Tan, Hui Li, Ying-Wei Li

Publikováno v: Biomedicine & Pharmacotherapy, Vol 155, Iss , Pp 113705- (2022)

Lung cancer is the leading cause of cancer-related death worldwide. The development of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and immune checkpoint inhibitors (ICIs) has brought favorable survival benefits to patients

Externí odkaz: https://doaj.org/article/13c6906933c846ea9c6ac806ba133309

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Akademický článek

Compensation of Zn substitution and secondary phase controls effective mass and weighted mobility in In and Ga co-doped ZnO material

Autor: Oanh Kieu Truong Le, Anh Tuan Thanh Pham, Ngoc Kim Pham, Trang Huyen Cao Pham, Truong Huu Nguyen, Dung Van Hoang, Hanh Kieu Thi Ta, Dai Cao Truong, Hoa Thi Lai, Thuy Dieu Thi Ung, Vinh Cao Tran, Thang Bach Phan

Publikováno v: Journal of Materiomics, Vol 7, Iss 4, Pp 742-755 (2021)

Conductivity σ and thermal conductivity κ are directly related to carrier concentration while Seebeck coefficient S is inversely proportional to carrier concentration. Therefore, improving thermoelectric (TE) performance is challenging. Here, the f

Externí odkaz: https://doaj.org/article/bf164e5861ab457aa023e06601922fdc

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Akademický článek

The Balance between Actin-Bundling Factors Controls Actin Architecture in Pollen Tubes

Autor: Ruihui Zhang, Xiaolu Qu, Meng Zhang, Yuxiang Jiang, Anbang Dai, Wanying Zhao, Dai Cao, Yaxian Lan, Rong Yu, Hongwei Wang, Shanjin Huang

Publikováno v: iScience, Vol 16, Iss , Pp 162-176 (2019)

Summary: How actin-bundling factors cooperatively regulate shank-localized actin bundles remains largely unexplored. Here we demonstrate that FIM5 and PLIM2a/PLIM2b decorate shank-localized actin bundles and that loss of function of PLIM2a and/or PLI

Externí odkaz: https://doaj.org/article/0f68af7b9a3d4548ad1f88c90725c618

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Akademický článek

Luteolin suppresses epithelial-mesenchymal transition and migration of triple-negative breast cancer cells by inhibiting YAP/TAZ activity

Autor: Dai Cao, Guo-Yuan Zhu, Yan Lu, Aiping Yang, Die Chen, Hui-Jie Huang, Shu-Xian Peng, Li-Wen Chen, Ying-Wei Li

Publikováno v: Biomedicine & Pharmacotherapy, Vol 129, Iss , Pp 110462- (2020)

Triple-negative breast cancer (TNBC) is a highly lethal subtype of breast cancer associated with early relapse and metastasis. Epithelial to mesenchymal transition (EMT) plays pivotal roles in the progression of TNBC, including inducing cancer stem c

Externí odkaz: https://doaj.org/article/d3e1772cdbde4d999f06376fd2994945

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Akademický článek

Gossypol overcomes EGFR-TKIs resistance in non-small cell lung cancer cells by targeting YAP/TAZ and EGFRL858R/T790M

Autor: Jian Xu, Guo-Yuan Zhu, Dai Cao, Hao Pan, Ying-Wei Li

Publikováno v: Biomedicine & Pharmacotherapy, Vol 115, Iss , Pp - (2019)

EGFR tyrosine kinase inhibitors (EGFR-TKIs) improve the progression-free survival of patients with non-small cell lung cancer (NSCLC). However, most patients inevitably developed drug resistance. EGFR T790 M mutation is the major mechanism for resist

Externí odkaz: https://doaj.org/article/1a1bd172479c4e279214dabaf816c65e

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