Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Dahong Li"'
Publikováno v:
Journal of Advanced Research, Vol 58, Iss , Pp 105-115 (2024)
Background: Diabetes mellitus (DM) is a long-term metabolic disease accompanied by difficulties in wound healing placing a severe financial and physical burden on patients. As one of the important signal transduction molecules, both endogenous and ex
Externí odkaz:
https://doaj.org/article/1bee5217f09a415f8626952d06b4390a
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 437-450 (2022)
Chromone has emerged as one of the most important synthetic scaffolds for antitumor activity, which promotes the development of candidate drugs with better activity. In this study, a series of nitrogen mustard derivatives of chromone were designed an
Externí odkaz:
https://doaj.org/article/2862e53dfeff450c895e20818b64f32b
Autor:
Xiang Gao, Baojia Sun, Yonglian Hou, Lilin Liu, Jianan Sun, Fanxing Xu, Dahong Li, Huiming Hua
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1870-1883 (2022)
Sinomenine, a morphinane-type isoquinoline-derived alkaloid, was first isolated from stems and roots of Sinomenium diversifolius (Miq.) in 1920. Later discovery by researchers confirmed various essential biological efficacy sinomenine exerted in vitr
Externí odkaz:
https://doaj.org/article/0e6ad54ab75440b89647c55ddddb1f49
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 9, Pp 3548-3566 (2022)
Molecular glues can specifically induce aggregation between two or more proteins to modulate biological functions. In recent years, molecular glues have been widely used as protein degraders. In addition, however, molecular glues play a variety of vi
Externí odkaz:
https://doaj.org/article/8eab255d70024f1eb82beb5d754e8d3d
Autor:
Peilu Song, Fan Zhao, Dahong Li, Jiqiang Qu, Miao Yao, Yuan Su, Hanxun Wang, Miaomiao Zhou, Yujie Wang, Yinli Gao, Feng Li, Dongmei Zhao, Fengjiao Zhang, Yu Rao, Mingyu Xia, Haitao Li, Jian Wang, Maosheng Cheng
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 6, Pp 2905-2922 (2022)
The p21 activated kinase 4 (PAK4) is serine/threonine protein kinase that is critical for cancer progression. Guided by X-ray crystallography and structure-based optimization, we report a novel subseries of C-3-substituted 6-ethynyl-1H-indole derivat
Externí odkaz:
https://doaj.org/article/f8f315b4d41341e19ffcb1ea0a529a41
Autor:
Mingying Wang, Xiaoyuan Chen, Ying Qu, Qingyinglu Ma, Huaqi Pan, Haonan Li, Huiming Hua, Dahong Li
Publikováno v:
Molecules, Vol 28, Iss 11, p 4284 (2023)
Brefeldin A has a wide range of anticancer activity against a variety of tumor cells. Its poor pharmacokinetic properties and significant toxicity seriously hinder its further development. In this manuscript, 25 brefeldin A-isothiocyanate derivatives
Externí odkaz:
https://doaj.org/article/82c990d822f147c5adaa6fb4de74b7f9
Publikováno v:
Marine Drugs, Vol 21, Iss 4, p 226 (2023)
Fascaplysin is a planar structure pentacyclic alkaloid isolated from sponges, which can effectively induce the apoptosis of cancer cells. In addition, fascaplysin has diverse biological activities, such as antibacterial, anti-tumor, anti-plasmodium,
Externí odkaz:
https://doaj.org/article/87f2474aae734db297de6436c1e43398
Autor:
Xu Hu, Yan Xiao, Jianan Sun, Bao Ji, Shanshan Luo, Bo Wu, Chao Zheng, Peng Wang, Fanxing Xu, Keguang Cheng, Huiming Hua, Dahong Li
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1148-1157 (2021)
As one of the most lethal diseases, pancreatic cancer shows a dismal overall prognosis and high resistance to most treatment modalities. Furthermore, pancreatic cancer escapes early detection during the curable period because early symptoms rarely em
Externí odkaz:
https://doaj.org/article/cd899665df9a4d9bae27ef15651ca5d8
Autor:
Dongyan Feng, Le Ren, Jiaqi Wu, Lingling Guo, Zhitao Han, Jingjing Yang, Wei Xie, Yanbing Wang, Fanxing Xu, Xin Su, Dahong Li, Hao Cao
Publikováno v:
Molecules, Vol 28, Iss 4, p 1883 (2023)
Furin is a potential target protein associated with numerous diseases; especially closely related to tumors and multiple viral infections including SARS-CoV-2. Most of the existing efficient furin inhibitors adopt a substrate analogous structure, and
Externí odkaz:
https://doaj.org/article/c0fa85bfa4c54b6fbaf93a538eee853c
Publikováno v:
Plants, Vol 12, Iss 1, p 192 (2023)
Phytochemical investigations of leaves and twigs from Garcinia oligantha Merr. resulted in the isolation of five undescribed triterpene derivatives (1–5) and six known analogs (6–11). Their structures were determined based on extensive spectrosco
Externí odkaz:
https://doaj.org/article/102a31ea1f4b480bb77a7269dc54d565