Concomitant Vascular Calsequestrin 2 overexpression and leukocytes transmigration in a rat model of skeletal muscle traumatic inflammatory injury

Autor: Noureddine Ben Khalaf, Dalal Al-Mehatab, Dahmani M. Fathallah

The network of molecular mediators involved in the transmigration of leukocytes to inflamed tissues has been expanding with the identification of new molecules involved in the inflammatory response. We have previously shown using a rat model that Pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab92b8231e08806a30011a2d727e9f21
https://doi.org/10.1101/2022.09.29.510069

A computer-aided approach to identify novel Leishmania major protein disulfide isomerase inhibitors for treatment of leishmaniasis

Autor: Giuseppe Romeo, Noureddine Ben Khalaf, Ivy Hurwitz, Douglas J Perkins, Loredana Salerno, Peter Sedillo, Susie Pham, Jessica Gonzales, Dahmani M. Fathallah, Sebastiano Intagliata, Valeria Pittalà, Sara Abdelghany

Publikováno v: Journal of Computer-Aided Molecular Design. 35:297-314

Leishmaniasis is an infectious disease caused by parasites of the genus Leishmania and transmitted by the bite of a sand fly. To date, most available drugs for treatment are toxic and beyond the economic means of those affected by the disease. Protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5f9eacec83e410b0f86a963fe4b14f
https://doi.org/10.1007/s10822-021-00374-w

Vascular endothelial ERp72 is involved in the inflammatory response in a rat model of skeletal muscle injury

Autor: Dahmani M. Fathallah, Noureddine Ben Khalaf, Dalal Al‑Μehatab

Publikováno v: Molecular Medicine Reports

The vascular inflammatory response involves the coordinated action of a large network of molecular mediators and culminates in the transmigration of leukocytes into the site of inflammation. Inflammatory mediators include a variety of protein familie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d066fa38f23b4c70050a8cdcd949f81
http://europepmc.org/articles/PMC7809907

Activation induced cytidine deaminase mutant (AID-His130Pro) from Hyper IgM 2 patient retained mutagenic activity on SHM artificial substrate

Autor: Benoit Arcangioli, Hanen Ouadani, Beya Larguèche, Imen Ben-Mustapha, Hatem Masmoudi, François Rougeon, Houda Elloumi-Zghal, Mohamed-Ridha Barbouche, Tihana Jovanic, Meriem Ben-Ali, Mongia Hachicha, Dahmani M. Fathallah, Sylvie Garcia

Publikováno v: Molecular Immunology
Molecular Immunology, 2016, 79, pp.77-82. ⟨10.1016/j.molimm.2016.09.025⟩
Molecular Immunology, Elsevier, 2016, 79, pp.77-82. ⟨10.1016/j.molimm.2016.09.025⟩

International audience; Activation induced cytidine deaminase (AID) is an essential enzyme for class switch recombination (CSR) and somatic hypermutation (SHM) during secondary immune response. Mutations in the AICDA gene are responsible for Hyper Ig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d198ff026ab2745225baea1a94295f
https://hal-riip.archives-ouvertes.fr/pasteur-01453058

Recombinant integrin CD11b A-domain blocks polymorphonuclear cells recruitment and protects against skeletal muscle inflammatory injury in the rat

Autor: S. Hammami, Samir Boubaker, A. Maaroufi, Jian-Ping Xiong, Dahmani M. Fathallah, E. Jerbi, K Zerria, M A Arnaout

Publikováno v: Immunology. 119:431-440

The beta2 integrin CD11b/CD18 (CR3) is a major adhesion receptor of neutrophils, normally utilized to fend off infections. This receptor contributes, however, to multiple forms of non-infectious inflammatory injury when dysregulated as shown in gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::399eb2a5a0f2de479c8d1c48ad0e757d
https://doi.org/10.1111/j.1365-2567.2006.02454.x