The newly identified MEK1 tyrosine phosphorylation target MACC1 is druggable by approved MEK1 inhibitors to restrict colorectal cancer metastasis

Autor: Kobelt, D., Perez-Hernandez, D., Fleuter, C., Dahlmann, M., Zincke, F., Smith, J., Migotti, R., Popp, O., Burock, S., Walther, W., Dittmar, G., Mertins, P., Stein, U.

Cancer metastasis causes >90% of cancer deaths and remains a major treatment challenge. Here we deciphered the impact of tyrosine phosphorylation of MACC1, a causative driver for cancer metastasis, for cancer cell signaling and novel interventions to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=mdc______med::97ec095d3d84619fc2a9f496ab2ef923
http://edoc.mdc-berlin.de/20415/13/20415suppl.zip

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Plasma levels of circulating MACC1 transcripts cosegregate with other prognostic markers and treatment response in glioblastoma patients

Autor: Hagemann, C, Neuhaus, N, Dahlmann, M, Kessler, AF, Kobelt, D, Herrmann, P, Eyrich, M, Freitag, B, Monoranu, CM, Ernestus, RI, Löhr, M, Stein, U

Publikováno v: 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie; 20180603-20180606; Münster; DOCP091 /20180618/

Objective: IDH1-mutation and MGMT-promoter methylation are established prognostic markers in Glioblastoma multiforme (GBM). However, invasive procedures are needed to obtain the required tumor tissue. Metastasis-associated in colon cancer-1 (MACC1) c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdddb2d710c151d5ea52994c7d8de9f

Expression of activating transcription factor 5 (ATF5) is increased in astrocytomas of different WHO grades and correlates with survival of glioblastoma patients

Autor: Feldheim J, Kessler AF, Schmitt D, Wilczek L, Linsenmann T, Dahlmann M, Monoranu CM, Ernestus RI, Hagemann C, Löhr M

Publikováno v: OncoTargets and Therapy, Vol Volume 11, Pp 8673-8684 (2018)

Jonas Feldheim,1 Almuth F Kessler,1 Dominik Schmitt,1 Lara Wilczek,1 Thomas Linsenmann,1 Mathias Dahlmann,2,3 Camelia M Monoranu,4 Ralf-Ingo Ernestus,1 Carsten Hagemann,1,* Mario Löhr1,* 1Department of Neurosurgery, Tumorbiology Labo­ratory, Univer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::28e288e679a998cb7d0545df30882a78
https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-177541