Zobrazeno 1 - 10 of 21 pro vyhledávání: '"Dahlia Doughty"'
1
Akademický článek
Metastasis-associated macrophages constrain antitumor capability of natural killer cells in the metastatic site at least partially by membrane bound transforming growth factor β
Autor: Demi Brownlie, Dahlia Doughty-Shenton, Daniel YH Soong, Colin Nixon, Neil O Carragher, Leo M Carlin, Takanori Kitamura
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
Background Metastatic breast cancer is a leading cause of cancer-related death in women worldwide. Infusion of natural killer (NK) cells is an emerging immunotherapy for such malignant tumors, although elimination of the immunosuppressive tumor envir
Externí odkaz: https://doaj.org/article/0a208b9ae45c43df991c0d62fdbd681b
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2
Akademický článek
Monocytes Differentiate to Immune Suppressive Precursors of Metastasis-Associated Macrophages in Mouse Models of Metastatic Breast Cancer
Autor: Takanori Kitamura, Dahlia Doughty-Shenton, Luca Cassetta, Stamatina Fragkogianni, Demi Brownlie, Yu Kato, Neil Carragher, Jeffrey W. Pollard
Publikováno v: Frontiers in Immunology, Vol 8 (2018)
Metastasis-associated macrophages (MAMs) play pivotal roles in breast cancer metastasis by promoting extravasation and survival of metastasizing cancer cells. In a metastatic breast cancer mouse model, we previously reported that circulating classica
Externí odkaz: https://doaj.org/article/52d88f23b1314fca953d0fa2325724ab
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4
Data from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF
Autor: Jeffrey W. Pollard, Neil Carragher, Dahlia Doughty-Shenton, Jiufeng Li, Nicolle Kippen, Gaël Sugano, Daniel Y.H. Soong, Demi Brownlie, Yu Kato, Takanori Kitamura
Metastasis-associated macrophages (MAM) promote persistent growth of breast cancer cells at the metastatic site and are, thus, an attractive therapeutic target to treat breast cancer metastasis, a leading cause of cancer-related death in women. Howev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7604ad4b2a5c0f858ca0e13433dcfd27
https://doi.org/10.1158/2326-6066.c.6550060
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5
A Novel High-Content Phenotypic Screen To Identify Inhibitors of Mitochondrial DNA Maintenance in Trypanosomes
Autor: Achim Schnaufer, John C. Dawson, Dahlia Doughty-Shenton, Migla Miskinyte, Neil O. Carragher, Ashraff Makda
Publikováno v: Miskinyte, M, Dawson, J C, Makda, A, Doughty-shenton, D, Carragher, N O & Schnaufer, A 2021, ' A novel high-content phenotypic screen to identify inhibitors of mitochondrial DNA maintenance in trypanosomes ', Antimicrobial Agents and Chemotherapy . https://doi.org/10.1128/AAC.01980-21
Kinetoplastid parasites cause diverse neglected diseases in humans and livestock, with an urgent need for new treatments. Survival of kinetoplastids depends on their uniquely structured mitochondrial genome (kDNA), the eponymous kinetoplast. Here we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa66611bb933a2c12e4e4554e88f180
https://doi.org/10.1128/aac.01980-21
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6
Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF
Autor: Jeffrey W. Pollard, Yu Kato, Gaël Sugano, Dahlia Doughty-Shenton, Demi Brownlie, Takanori Kitamura, Neil O. Carragher, Jiufeng Li, Daniel Y.H. Soong, Nicolle Kippen
Publikováno v: Kitamura, T, Kato, Y, Brownlie, D, Soong, D, Sugano, G, Kippen, N, Li, J, Doughty-Shenton, D, Carragher, N & Pollard, J W 2019, ' Mammary tumor cells with high metastatic potential are hypersensitive to macrophage-derived HGF ', Cancer Immunology Research, vol. 7, no. 12, pp. 2052-2064 . https://doi.org/10.1158/2326-6066.CIR-19-0234
Cancer Immunol Res
Metastasis-associated macrophages (MAM) promote persistent growth of breast cancer cells at the metastatic site and are, thus, an attractive therapeutic target to treat breast cancer metastasis, a leading cause of cancer-related death in women. Howev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2b9a7610901026772cc5931ae4c3b8
https://doi.org/10.1158/2326-6066.cir-19-0234
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7
Metastasis-associated macrophages constrain antitumor capability of natural killer cells in the metastatic site at least partially by membrane bound transforming growth factor β
Autor: Leo M. Carlin, Dahlia Doughty-Shenton, Takanori Kitamura, Demi Brownlie, Neil O. Carragher, Colin Nixon, Daniel Yh Soong
Publikováno v: Brownlie, D, Doughty Shenton, D, Soong, D, Nixon, C, Carragher, N O, Carlin, L M & Kitamura, T 2021, ' Metastasis-associated macrophages constrain anti-tumor capability of natural killer cells in the metastatic site at least partially by membrane bound transforming growth factor ', Journal for immunotherapy of cancer, vol. 9, no. 1, e001740 . https://doi.org/10.1136/jitc-2020-001740
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
Brownlie, D, Doughty-shenton, D, Yh Soong, D, Nixon, C, O Carragher, N, M Carlin, L & Kitamura, T 2021, ' Metastasis-associated macrophages constrain antitumor capability of natural killer cells in the metastatic site at least partially by membrane bound transforming growth factor β ', Journal for immunotherapy of cancer, vol. 9, no. 1, pp. e001740 . https://doi.org/10.1136/jitc-2020-001740
Journal for Immunotherapy of Cancer
BackgroundMetastatic breast cancer is a leading cause of cancer-related death in women worldwide. Infusion of natural killer (NK) cells is an emerging immunotherapy for such malignant tumors, although elimination of the immunosuppressive tumor enviro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62547a0df7d50d0d78954a4dc09b534c
https://eprints.gla.ac.uk/232437/1/232437.pdf
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10
Machine Learning Enables Live Label-Free Phenotypic Screening in Three Dimensions
Autor: Catarina Sepulveda, Neil O. Carragher, Eoghan O'Duibhir, Kamil R. Kranc, Hannah Lawson, Dahlia Doughty Shenton, Jasmin Paris
Publikováno v: O'Duibhir, E, Paris, J, Lawson, H, Pires Sepulveda, C, Doughty Shenton, D, Carragher, N & Kranc, K 2018, ' Machine Learning Enables Live Label-Free Phenotypic Screening in Three Dimensions ', Assay and Drug Development Technologies, vol. 16, no. 1, pp. 51-63 . https://doi.org/10.1089/adt.2017.819
There is a large amount of information in brightfield images that was previously inaccessible by using traditional microscopy techniques. This information can now be exploited by using machine-learning approaches for both image segmentation and the c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e380d37a2586d82b8736fad8244c96
https://pubmed.ncbi.nlm.nih.gov/29345979
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